Nov. 1st, 2007 - Nov. 1st, 2008  Obesity Alliance Weekly CME Conference

NOVEMBER 2007

• November 1, 2007
  Steven Smith, MD
  "Intrinsic Defects in Substrate Switching in Skeletal Muscle: A Precursor to Obesity and Diabetes"
• November 8, 2007
  Joel Goodman, Ph.D.
  "Peroxisomes, Lipid Droplets, and Lipodystrophy - All in Yeast!"
• November 15, 2007
  Helen Hobbs, MD
  "The Dallas Heart Study - History & Future"
• November 29, 2007
  Robert Hegele, MD, FRCPC, FACP
  "Genetic forms of the cardiometabolic syndrome"

• December 6, 2007
  Kenneth Cusi, MD, FACE
  " Nonalcoholic Fatty Liver Disease (NAFLD):Time for New Treatment Strategies?"

• December 13, 2007
  Charles Rosenfeld, MD
  "Insulin Resistance in Hispanic Large-for-Gestational Age Neonates at Birth"
• December 20, 2007
  David Self, Ph.D.
  "Mechanisms of D2 Receptor Sensitization in Cocaine Relapse"
• December 27, 2007- rescheduled
  Colleen A. McClung, Ph.D.
  "Circadian Genes, Rhythms and the Biology of Mood Disorders and Obesity Phenotype"
• Thursday, January 03, 2008 
  Stanley Hazen, M.D., Ph.D.
  “ HDL: Lipoprotein Particle at the Crossroads of Dyslipidemia, Inflammation and Cardiovascular Disease”
  Special Seminar at 1:00 PM, Y6.224 (Non-CME)
  ------------------------------------------------------------------------------------------------------------

   2008 Lectures 

• Thursday, January 10, 2008
  Philip W. Shaul, M.D.
  "CRP and the Metabolic Syndrome: Marker or Mediator?"
• Thursday, January 17, 2008
  Makoto Kuro-O, MD, Ph.D.
  "The Klotho gene-family regulators of FGF and metabolism"
• Thursday, January 24, 2008
  Rex Ahima, M.D., Ph.D.
  "Resistin"
• Thursday, January 31, 2008
  Stephen Farmer, Ph.D.
  "Role of PPARgamma and SIRT1 in Regulating Adipocyte Formation and Function"
• Thursday, February 07, 2008
  Michael Jensen, MD
  "Adipose Tissue Metabolism - An Aspect We Should not Neglect?"
• Thursday, February 14, 2008
  Coleen A. McClung, Ph. D.
  "Circadian Genes, Rhythms and the Biology of Mood Disorders and Obesity Phenotype"
• Thursday, February 21, 2008 
  Robert Bachoo, M.D., Ph.D
  "GBM Metabolism: The genetics of supply and demand"
• Thursday, February 28, 2008
  Randy Seeley, Ph.D.
  "How obesity went to our heads: Novel aspects of the neuroendocrine control of energy balance"
• Thursday, March 06, 2008
  Leon Avery, Ph.D., MBA
  "Molecular basis of feeding regulation"
• Thursday, March 13, 2008
  Philipp Scherer, Ph.D.
  "The role of adipokines in Diabetes, Obesity and Lipid Metabolism"
• Thursday, March 20, 2008
  Michael Schwartz, M.D.
  "Diabetes, Obesity and the Brain"
• Thursday, March 27, 2008 
  Hei Sook Sul, Ph.D.
  "A tale of two local adipose regulatiors: Pref-1 and AdPLA"
• Thursday, April 03, 2008
  Giuseppe Novelli, M.D
  "Simple genotypes and complex phenotypes: The strange case of Mr. Lamin gene"
• Thursday, April 10, 2008
  Jon Graff, MD, Ph.D.
  "Fat Pharm: New approaches to regulating metabolism"
• Thursday, April 17, 2008
  Carol Elias, Ph.D.
  "Hypothalamic pathways linking leptin action and reproduction"
• Thursday, April 24, 2008
  Rudolph L. Leibel, M.D.
  "Molecular Physiology of the Control of Body Weight"
• Thursday, May 08, 2008
  Roger H. Unger, M.D.
  "Leptin,lipotoxicity and lipid partitioning: How adipogenic capacity determines susceptibility to T2D and metabolic syndrome".
• Thursday, May 15, 2008
  Timothy F. Osborne, Ph.D."
  "Transcriptional Regulation of Lipid Metabolism"
• Thursday, May 22, 2008
  Russell Debose-Boyd, Ph.D.
  "Feedback regulation of cholesterol synthesis through ER-associated degradation of HMG CoA reductase."
• Thursday, May 29, 2008
  Lora Hooper, Ph.D.
  "Innate immune responses to commensal bacteria at gut epithelial surfaces"
• Thursday, June 05, 2008
  Matthias Tschoep, M.D.
  "The gut-brain axis in metabolic regulation"
• Thursday, June 12, 2008
  Ruth McPherson, M.D., Ph.D.
  "Genetic Complexity of Obesity"
• Thursday, June 19, 2008
  David Russell, PhD
  "Cholesterol Turnover in the Brain"
• Thursday, June 26, 2008
  Joel Elmquist, DVM, PhD
  "Hypothalamic integration of metabolic cues into coordinated physiological responses"
• Thursday, July 03, 2008
  No meeting
• Thursday, July 10, 2008
  Masashi Yanagisawa, M.D., Ph.D.
  "Orexin: A link between sleep/wake and energy homeostasis?"
• Thursday, July 17, 2008
  Craig Malloy, M.D
  "Non-invasive analysis of adipose composition in humans"
• Thursday, July 24, 2008
  Anna Mae Diehl, M.D.
  "Fixing Fatty Livers"
• Thursday, July 31, 2008 
  Melanie Cobb, PhD
  “MAPKs in beta cell function”
• Thursday, August 07, 2008 
  Burant, Charles MD
  "Hepatic Steatosis and Insulin Resistance in Hepatitis C"
• Thursday, August 14, 2008
  Timothy E. Graham, MD
  "RBP4 and Insulin Resistance: New Insights into Physiological Function and Cellular Mechanism"
• Thursday, August 21, 2008
  Donalyn Scheuner, Ph.D.
  "The Role of Endoplasmic Reticulum Stress in Beta Cell Biology and Metabolic Disease"
• Thursday, August 28, 2008
  Anthony Scime, Ph.D.
  "A Role of p107 in Mesodermal Cell Fate Decisions"
• Thursday, Sep. 4, 2008
  Kevin Grove, Ph.D.
  "Fetal lipotoxicity and the development of metabolic system in the nonhuman primate"
• Thursday Sep. 11, 2008
  Philip Kern, M.D.
  "Insulin resistance: changes in gene expression related to lipid partitioning and inflammation"
• Thursday Sep. 18, 2008
  Deborah L. Clegg
  "Sex Matters!"
• Thursday, Sep. 25, 2008
  Steven K. Grinspoon, MD
  "Pathophysiology and Management of Fat Redistribution in HIV Lipodystrophy"
• Thursday, October 02, 2008
  Keith Parker, M.D., Ph.D.
  "Steroidogenic factor 1: key mediator of endocrine function."
• Thursday, October 09, 2008
  Jonathan C. Cohen, Ph.D.
  "Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease"
• Thursday, October 16, 2008
  Abhimanyu Garg, M.D.
  "Leptin Therapy: The promise, the disappointment and the sliver lining"
• Thursday, October 23, 2008
  Shawn Burgess, Ph.D.
  " Integrated Metabolism of Hepatic Fat Oxidation and Gluconeogenesis"
• Thursday, October 30, 2008
  David Y. Hui, Ph.D.
  "A tale of Two LDL receptor family proteins LRP1 and LRP8 in vascular cell homeostasis"
• Thursday, November 6, 2008
  Jonathan Purnell , M.D.
  "Nutrient regulation of food intake in humans"
• Thursday, November 13, 2008
  J. Eduardo Rame, M.D., M.Phil.
  "Caloric Restriction, Cardiac Lipotoxicity, and Leptin: A Study of the ob/ob Murine Model"
• Thursday, November 20, 2008 (Special lecture; Non-CME)
  Alan Cherrington, Ph.D.
  “New Concepts in Insulin’s Regulation of Glucose Production In Vivo”
• Thursday, December 4, 2008
  Thomas Wilkie, Ph.D.
  "RGS/G-protein control of glucose homeostasis in liver metabolism and
  pancreas development"
• Thursday, December 11, 2008
  Jean J. Zhao, Ph.D.
  "Isoforms of PI3K in cancer and metabolism"
• Thursday, December 18, 2008
  Robert D. Toto, M.D.
  "Microalbuminuria, Obesity and Cardiovascular Disease Risk"------------------------------------------------------------------------------------------------------------
  
  2009 Lectures
  
  
• Thursday, January 8, 2009
  Amit Khera, M.D.
  "Gender Dimorphism in Obesity and C-reactive protein"
• Thursday, January 15, 2009
  Daniel Rader, M.D.
  "Effects of Microsomal Triglyceride Transfer Protein (MTP) inhibition on lipids, hepatic fat, and weight in humans: an update"
• Thursday, January 22, 2009
  Ronald Peshock, M.D.
  "Cardiovascular Risk Assessment by Imaging Methods in the Dallas Heart Study"
• Thursday, January 29, 2009
  Leslie B. Vosshall, PhD
  "Connecting Smell to Food Intake"
• Thursday, February 5, 2009
  Roger Unger, M.D.
  "The Trihormonal Pathogenesis of Type 1 Diabetes: Triple Trouble Hypothesis"
• Thursday, February 12, 2009 (Non-CME)
  Michael S. Brown, M.D.
  "The SREBP Pathway: Membrane Molecules in Motion
• Thursday, February 19, 2009 (Non-CME)
  Richard Bergman, Ph.D.
  "Pathogenesis of the Metabolic Syndrome”
• Thursday, February 26, 2009
  David D'Alessio, M.D.
  "Neuroendocrine mediation of the incretin effect: GLP-1 as a link between the CNS and peripheral metabolism"
• Thursday, March 5, 2009
  Vincent Aguirre, M.D.
  "The Physiology of Gastric Bypass and Implications for Endoluminal Therapy of Obesity and Diabetes"
• Thursday, March 12, 2009
  Steven Young, M.D.
  "An endothelial cell molecule required for the processing of triglyceride-rich lipoproteins"
• Thursday, March 19, 2009
  Marc Hellerstein, M.D., Ph.D.
  “Effects of caloric restriction and intermittent fasting regimens on functionally significant in vivo target pathways, including dynamics of adipose tissue components”
• Thursday, March 26, 2009
  Evan D. Rosen, M.D., Ph.D.
  "Pathway Discovery in Adipocyte Biology Using Epigenomics"
• Thursday, April 02, 2009
  John Dietschy, M.D.
  "Metabolic consequences of reversing the defect in cholesterol transport in Niemann-Pick disease"
• Thursday, April 09, 2009
  Roberto Coppari, Ph.D.
  "Brain SIRT1: A novel target to treat diet-induced metabolic dysfunctions?"
• Thursday, April 16, 2009
  Dennis Voelker, Ph.D.
  "The minor pulmonary surfactant phospholipids play a major role in regulating inflammation and infection in the lung"
• Thursday, April 23, 2009
  Jay D. Horton, M.D.
  "Identification and Characterization of a New Modulator of Lipogenesis"
• Thursday, April 30, 2009
  Joel M Goodman, Ph.D.
  "Lipodystrophy in yeast"
• Thursday, May 07, 2009
  James de Lemos, M.D.
  "Biomarkers in the Dallas Heart Study"
• Thursday, May 14, 2009
  Elisa Fabbrini, M.D., Ph.D.
  "Obesity and Nonalcoholic fatty liver disease"
• Thursday, May 21, 2009
  Joseph Witztum, M.D.
  "Oxidation-specific epitopes are a major target of innate immunity: Implications for health and disease"
• Thursday, May 28, 2009 (Non-CME)
  Susan Hutson, PhD
  "Leucine Signaling: Fact and Fancy"
• Thursday, June 04, 2009
  Gregory O'Neal Clark, M.D.  
  "Type 1 Diabetes - What Are We Missing?"
• Thursday, June 11, 2009
  Darren McGuire, M.D.
  "Effects of Rosiglitazone on Integrated Cardiovascular Performance, Cardiac Structure and Function"
• Thursday, June 18, 2009
  Kimberly K. Buhman, Ph.D.
  "The Small Intestine: A Role in Fat Storage"
• Thursday, June 25, 2009
  Joseph A Hill, M.D., Ph.D.
  "Pathological Cardiac Remodeling: Mechanisms and Therapies"
• Thursday, July 09, 2009
  Tony K Lam, Ph.D.
  "Nutrient Sensing in the Gut and Brain"
• Thursday, July 16, 2009
  Eric N. Olson, Ph.D.
  "Toward microRNA-based therapeutics for heart disease"
• Thursday, July 23, 2009
  Steven Kliewer, Ph.D.
  "FGF21 in Metabolism: From Feast to Famine"
• Thursday, July 30, 2009
  Vanessa Sperandio, Ph.D.
  "Inter-kingdom signaling: communication between bacteria and host"
• Thursday, August 06, 2009
  Jay W. Schneider, M.D., Ph.D.
  "Gene-activating small molecule and diabetes"
• Thursday, August 13, 2009
  Donald B. Jump, Ph.D.
  "Polyunsaturated fatty acid synthesis: A pathway controlling multiple hepatic functions"
• Thursday, August 20, 2009
  Abhimanyu Garg, M.D.
  "Molecular Mechanisms of Hepatic Steatosis in Lipodystrophies"
• Thursday, August 27, 2009
  Gary D. Hammer, M.D., Ph.D.
  "In search of adrenocortical stem cells: Implications for adrenal cancer"
• Thursday, September 03, 2009
  Fredric Wondisford, M.D.
  "Transcriptional Control of Hepatic Gluconeogenesis in Obesity"
• Thursday, September 10, 2009
  Anthony Hollenberg, M.D.
  "New Insights into Thyroid Hormone Signaling and the Regulation of the Thyroid Axis"
• Thursday, September 17, 2009
  Jose M. Garcia, M.D.
  "Ghrelin in cancer related cachexia"
• Thursday, September 24, 2009
  Andrew Zinn, M.D., Ph.D.
  "Sim1 and Obesity: Development or Physiology?"
• Thursday, October 01, 2009
  Doris Stoffers, M.D., Ph.D.
  "Pdx1 partners and targets in the development and function of pancreatic beta cells"
• Thursday, October 08, 2009- Will be rescheduled at another time.
  Jens Bruning, M.D.
  "Neuronal insulin action in control of glucose and energy homeostasis"
• Thursday, October 15, 2009
  "McGarry Symposium: "Metabolic Control of Complex Systems"
  North campus ND 3rd floor, T. Boone Pickens Conference Hall
• Thursday, October 22, 2009
  Neil B. Ruderman, M.D., Ph.D.
  "AMP Kinase/SERT1: A longstanding Partnership"
• Thursday, October 29, 2009
  Meng Wang, Ph.D.
  "Endocrine and metabolic signaling in promoting healthy aging"
• Thursday, November 05, 2009
  Jens Bruning, M.D.
  "Neuronal insulin action in control of glucose and energy homeostasis"
• Thursday, November 12, 2009
  Daniel J Drucker, M.D.
  "Incretin-based therapies-promises and pitfalls"
• Thursday, November 19, 2009
  Steven Shoelsen, M.D., Ph.D.
  "Obesity-Induced Inflammation: Pathogenesis and Potential New Treatments in Diabetes and Cardiovascular Disease"
• Thursday, December 03, 2009
  Yong-Xu Wang, Ph.D.
  "A transcriptional network in brown fat metabolism"
• Thursday, December 10, 2009
  Stephen H Caldwell, M.D.
  "Perspectives on NASH"
• Thursday, December 17, 2009
  Richard Auchus, M.D., Ph.D.
  "Fat Wars II: Attack of the Steroids"
  ______________________________________________________________________________
  
  2010 Lectures
  
• Thursday, January 7, 2010
  Don Rockey, M.D.
  “The cell and molecular basis of cirrhosis: A bench to bedside approach”
• Thursday, January 14, 2010
  Deborah J. Clegg, Ph.D.
  "Males need E₂"
• January 21, 2010
  Myron F. Weiner, M.D. and Laura Lacritz. Ph.D.
  "Cognition in the Dallas Heart Study: Preliminary Results"
• January 28, 2010
  Roberto Coppari Ph.D.
  "Metabolic Actions of Brain SIRT1"
• February 4, 2010
  Roger Unger, M.D.
  "Restoring Homeostasis in Type 1 Diabetes: Lipoanabolic versus Lipocatabolic Therapies"
• February 11, 2010
  Robert Eckel, M.D.
  "Triglyceride-Rich Particles and the CNS Regulation of Body Weight and Energy Balance"
• February 18, 2010
  John D. Minna, M.D.
  "Molecular Pathogenesis of Lung Cancer With Translation to the Clinic"
• February 25, 2010
  Mitchell A. Lazar, M.D., Ph.D.
  "Nuclear Receptors and the Epigenomic Regulation of Metabolism"
• March 4, 2010
  Morris F White, Ph.D.
  "IRS2, The Good Cop and Bad Cop of Insulin Signaling"
• March 11, 2010
  Peter Butler, M.D.
  "The Islet and Liver in Type 2 Diabetes, Partners in Loss of Glycemic Control"   
• March 18, 2010
  Elizabeth Parks, Ph.D.
  "The impact of nutrient metabolism on hepatic steatosis"
• March 25, 2010
  Michael Lutter, M.D., Ph.D.
  "Chronic Social Defeat Stress Disrupts Regulation of Lipid Synthesis "
• April 1, 2010
  Makoto Kuro-o, M.D., Ph.D.
  "Phosphate metabolism, chronic kidney disease, and aging"
• April 8, 2010
  Carol Tamminga, M.D.
  "Brain Modulation of Feeding in Human Obesity"
• April 15, 2010
  Jeffrey Zigman, M.D., Ph.D.
  "Ghrelin: Mediator of Metabolism, Mood and Motivation"
• April 22, 2010
  Steven Patrie, Ph.D.
  "Mass Spectrometry and protein biochips for the characterization of neurodegeneration"
• April 29, 2010
  Raul Mostoslavsky, M.D., Ph.D.
  "The histone deacetylase SIRT6 is a master regulator of glucose homeostasis"
• May 6, 2010
  Ralph J. DeBerardinis, MD, PhD
  "The Warburg effect, the Truncated TCA Cycle, and Other Mysteries of Tumor Metabolism"
• May 13, 2010
  Ronald Haller, M.D.
  "Fueling muscle contraction: insights from McArdle disease"
• May 20, 2010
  Joel Elmquist, D.V.M, Ph.D.
  "Molecular Mechanisms Linking Glucose Homeostasis, Energy Balance and Mood"
• May 27, 2010
  Robert D. Toto, M.D.
  "Is Chronic Kidney Disease a Coronary Risk Equivalent?"
• June 3, 2010
  Willa A. Hsueh, M.D.
  "You can't get old and eat fat"
• June 10, 2010
  Joyce Repa, PhD
  "Nuclear Hormone Receptors and the Endocrine Pancreas"
• June 17, 2010
  Jonathan C Cohen, Ph.D.
  "Fatty liver and insulin resistance: lessons from genetics"
• June 18, 2010 - non CME credit- special seminar
  Ashok Balasubramanyam, M.D.
  "HIV Lypodystrophy Syndrome: Mechanisms and Management"
• June 24, 2010
  Beth Levine, M.D.
  "Autophagy: Regulation, Functions, and Potential Links to Obesity"
• July 1, 2010
  Richard G. Pestell, M.D., Ph.D.
  "Cyclin D1 in Metabolism & Metastasis, New Findings"
• July 8, 2010
  Joseph Takahashi, Ph.D.
  "Clock genes, cell autonomous clocks and circadian organization"
• July 15, 2010
  Perry E. Bickel, M.D.
  "Exchangeable lipid droplet proteins in the control of cellular lipid metabolism"
• July 22, 2010
  Philipp Scherer, Ph.D.
  "Adiponectin and its Receptors: Biomarkers at Best or Key Regulators for Metabolism and Cancer?"
• July 29, 2010
  Joachim Herz, M.D.
  "ApoE and ApoE receptors as modulators of synaptic function"
• August 5, 2010
  No seminar scheduled
• August 12 - September 2: Summer Recess