Cell Regulation Faculty

Program Chair:  Paul Sternweis

Joseph Albanesi -- Mechanisms of membrane fusion; Role of lipids in membrane trafficking; Membrane vesiculation of dynamin.

Neal Alto -- The intersection between human signal-transduction and bacterial pathogenesis; use of biochemical and cell biological analysis to define molecular mechanisms of microbial infectious disease.

Steven Altschuler - Design principles underlying the spatial-temporal organization of molecular networks. 

Richard Anderson -- Compartmentalization of signal transduction by caveolae and coated pits.

James Bibb -- Protein phosphorylation/dephosphorylation related to neural function.

Kathlynn Brown -- Cell-specific targeting; receptor-ligand interactions; cancer targeting; drug delivery; cancer biomarker identification.

Michael Brown -- Regulation of gene expression; cell-surface receptor function; genetics and biochemistry of lipoprotein and cholesterol metabolism.

David Chen -- Role of DNA-PK in DNA double-strand break repair; Ku, telomere maintenance and cellular senescence; transgenic mouse models for DNA damage sensing and signaling; DNA damage responses induced by HZE particles in human cells.

Cheng-Ming Chiang-- Mechanisms of transcriptional regulation and epigenetic control; chromatin remodeling and histone tail modification; sumoylation and ubiquitination; functional interplay between oncoproteins and tumor suppressor proteins; general transcription factors and cofactors.

Melanie Cobb -- Protein kinase cascades; MAP kinases; signal-transduction mechanisms.

Russell DeBose-Boyd -- Regulation of HMG-CoA reductase and sterol metabolism.

J. R. Falck -- Total synthesis of natural products; synthetic methodology; organometalics; eicosanoids; medicinal chemistry.

Beatriz M.A. Fontoura -- Role of nuclear transport factors in interphase and mitosis: from viral pathogenesis to cell division.

Alfred Gilman -- Hormonal regulation of cyclic AMP metabolism; mechanisms of control of hormone-sensitive adenylate cyclase; regulatory GTP-binding proteins.

Joseph Goldstein -- Genetics and biochemistry of lipoprotein and cholesterol metabolism; cell-surface receptor function; regulation of gene expression.

Joel Goodman -- Intracellular sorting of newly synthesized proteins; organelle biogenesis and membrane structure and function; the yeast peroxisome as a model of organellar assembly.

Jer-Tsong (J.T.) Hsieh -- Human cancer gene therapy; signaling defects in urogenital cancers.

Lily Huang -- Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer.

Michele Hutchison -- Regulation of cell growth and differentiation affecting bone growth; action of IGF-I at the growth plate; skeletal dysplasias.

Lily Jiang -- Adenylyl cyclase regulation and function in the immune system; novel pathways of G protein signaling.

Steven Kliewer -- Physiology of nuclear receptors.

Mark Lehrman -- Informational carbohydrates in the endoplasmic reticulum:  roles in protein folding, stress responses and human disease.

David Mangelsdorf -- Mechanism of nuclear hormone receptor action; role of retinoids in cancer; transcriptional regulation of lipid metabolism.

Carole Mendelson -- Molecular mechanisms in tissue-specific, developmental and hormonal regulation of eukaryotic gene expression.

John Minna -- Molecular genetics of human cancer; growth factors and signal transduction in human tumors.

Marc Mumby -- Signaling pathways controlling cell growth and transformation.

Kate Luby-Phelps -- Light microscope imaging of structure and function in living cells and tissues.

Matthew Porteus -- Regulation of DNA double-stranded break repair; regulation of homologous recombination. 

Elliott Ross -- Mechanisms and regulatory behavior of G-protein signaling; regulated protein-protein interactions in signal transduction.

Michael Roth -- Recognition and sorting of cell-surface glycoproteins.

David Russell -- Steroid and bile-acid metabolism; molecular genetics; gene regulation; protein structure-function.

Philipp Scherer - Identification and physiological characterization of novel secretory proteins that serve as potential links between the adipocyte and the processes of whole body energy homeostasis, inflammation and cancer; beta cell biology.

Joachim Seemann -- Biogenesis of the Golgi apparatus.

Dean Smith -- Sensory transduction in Drosophila melanogaster.

William Snell -- Cell-cell interactions and signal transduction during fertilization in Chlamydomonas; cellular and molecular mechanisms of cell-cell fusion.

Paul Sternweis -- Regulation of intracellular events by cell-surface receptors; structure and function of GTP-dependent regulatory proteins and their effectors.

Ronald Taussig -- G protein-mediated signaling.

Lance Terada -- Vascular biology; oxidant biochemistry; signal transduction; acute lung injury.

Philip Thorpe -- Development of novel angiogenesis inhibitors and agents for inducing thrombosis of tumor blood vessels for cancer treatment.

Michael White -- Molecular mechanisms for control of cell growth and differentiation.

Lani Wu - Design principles underlying the formation of cellular polarity. 

Christoph Wuelfing -- Regulation of cytoskeletal rearrangements during T lymphocyte activation.

Helen Yin -- Mechanisms for signal transduction through the actin cytoskeleton.

Hongtao Yu -- Study of cell division cycle.

Gang Yu -- Biochemistry of signal transduction, gene regulation, and membrane protein complexes; molecular and cellular mechanisms of neurogenesis, neuroplasticity, and neurodegeneration.

Hui Zou -- Molecular circuitries that ensure a timely and equal separation of chromosomes into the forming daughter cells; vertebrate mechanisms of chromatid cohesion and separation; unequal division of cytoplasmic content during asymmetric cell divisions.