Cell Signaling Training Track Faculty

Track Chair:  Paul Sternweis

James Bibb -- Protein phosphorylation/dephosphorylation related to neural function.

Kathlynn Brown -- Cell-specific targeting; receptor-ligand interactions; cancer targeting; drug delivery; cancer biomarker identification.

David Chen -- Role of DNA-PK in DNA double-strand break repair; Ku, telomere maintenance and cellular senescence; transgenic mouse models for DNA damage sensing and signaling; DNA damage responses induced by HZE particles in human cells.

Cheng-Ming Chiang -- Mechanisms of transcriptional regulation and epigenetic control; chromatin remodeling and histone tail modification; sumoylation and ubiquitination; functional interplay between oncoproteins and tumor suppressor proteins; general transcription factors and cofactors.

Melanie Cobb -- Protein kinase cascades; MAP kinases; signal-transduction mechanisms.

Russell DeBose-Boyd -- Regulation of HMG-CoA reductase and sterol metabolism.

J. R. Falck -- Total synthesis of natural products; synthetic methodology; organometalics; eicosanoids; medicinal chemistry.

Alfred Gilman -- Hormonal regulation of cyclic AMP metabolism; mechanisms of control of hormone-sensitive adenylate cyclase; regulatory GTP-binding proteins.

Joseph Goldstein -- Genetics and biochemistry of lipoprotein and cholesterol metabolism; cell-surface receptor function; regulation of gene expression.

Stephen Hammes -- Analysis of nongenomic steroid signaling; progesteronemediated maturation of oocytes.

Lily Huang -- Cytokine receptor; signal transduction; hematopoiesis; structure-function analysis of protein; cancer.

Steven Kliewer -- Physiology of nuclear receptors.

Mark Lehrman -- Informational carbohydrates in the endoplasmic reticulum:  roles in protein folding, stress responses and human disease.

David Mangelsdorf -- Mechanism of nuclear hormone receptor action; role of retinoids in cancer; transcriptional regulation of lipid metabolism.

Carole Mendelson -- Molecular mechanisms in tissue-specific, developmental and hormonal regulation of eukaryotic gene expression.

John Minna -- Molecular genetics of human cancer; growth factors and signal transduction in human tumors.

Marc Mumby -- Signaling pathways controlling cell growth and transformation.

Matthew Porteus -- Regulation of DNA double-stranded break repair; regulation of homologous recombination. 

Elliott Ross -- Mechanisms and regulatory behavior of G-protein signaling; regulated protein-protein interactions in signal transduction.

David Russell -- Steroid and bile-acid metabolism; molecular genetics; gene regulation; protein structure-function.

Dean Smith -- Sensory transduction in Drosophila melanogaster.

Paul Sternweis -- Regulation of intracellular events by cell-surface receptors; structure and function of GTP-dependent regulatory proteins and their effectors.

Ronald Taussig -- G protein-mediated signaling.

Lance Terada -- Vascular biology; oxidant biochemistry; signal transduction; acute lung injury.

Philip Thorpe -- Development of novel angiogenesis inhibitors and agents for inducing thrombosis of tumor blood vessels for cancer treatment.

Michael White -- Molecular mechanisms for control of cell growth and differentiation.

Thomas Wilkie -- Signal-transduction pathways in mammalian development and energy homeostasis.

Masashi Yanagisawa -- Identification and characterization of new signaling molecules that regulate vital functions such as sleep, appetite and blood pressure.

Hongtao Yu -- Study of cell division cycle.