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CYP17 (17-hydroxylase, left) and CYP21 (21-hydroxylase, right) share 29% amino acid identity yet selectively hydroxylate progesterone at carbon atoms that are only 1.6 Å apart. Our laboratory uses computer modeling, molecular dynamics simulations, and site-directed mutagenesis experiments to study why these enzymes appear so similar yet possess different activities that fulfill diametrically opposite functions in human physiology. |
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Richard Auchus, M.D., Ph.D.
Division of Endocrinology and Metabolism,
Department of Internal Medicine
Southwestern Medical School
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Molecular Biophysics Graduate Program
Southwestern Graduate School of Biological Sciences
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| | Auchus Lab | |
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| Richard Auchus |
| | | Lab Interests | |
| | | Lab Members | | Web page under construction
| | | Positions Available | | Please email Richard Auchus for more information. | |
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