George R. Buchanan, M.D.
Professor of Pediatrics
Children’s Cancer Fund Distinguished Chair in Pediatric Oncology and Hematology
Director, Barrett Family Center for Pediatric Oncology
Medical Director, Center for Cancer and Blood Disorders

• Prevention and treatment of vaso-occlusive complications of sickle cell disease during infancy, childhood, and adolescence
• Management and natural history of childhood idiopathic thrombocytopenic purpura during childhood, with particular emphasis on studying outcome measures other than platelet count (e.g., bleeding signs and symptoms, cost of therapy, and quality of life)
• Development of improved means of diagnosing and treating patients with hemophilia and other hereditary blood coagulation disorders, with special emphasis on eliminating the complications of the disease and its therapy
• Long-term complications of splenectomy
• Diagnosis, management, and advocacy regarding Diamond Blackfan Anemia
• Serving as research advisor and mentor to young people (medical students, residents, fellows, and junior faculty) engaged in or planning a career in academic pediatric hematology-oncology

                                Patrick Leavey, M.D. and visiting Pediatric Oncologist, Tim Cripe, M.D

                                                        Patrick Leavey, M.D.
Associate Professor of Pediatrics
Director, Pediatric Hematology-Oncology Fellowship Program
Clinical Director, Center for Cancer and Blood Disorder

• Study of bevacizumab (Avastin) in a chemotherapeutic regimen for first recurrent Ewing Sarcoma
• Study of proteomic micro-array profile of cytokine/chemokine expression in pediatric patients with fever and neutropenia (F N)
• Study of radiation-induced pulmonary injury in survivors following whole lung radiation therapy for a childhood malignancy
• Study of intra-abdominal Ewing Sarcoma (EWS) and primitive neuroectodermal tumor (PNET) in children
• Hematology-Oncology Fellowship Program Director

                                                           Naomi J. Winick, M.D.
Professor of Pediatrics
Lowe Foundation Professor in Pediatric Neuro-Oncology

• Design of clinical trials in childhood acute lymphoblastic leukemia, with special emphasis on use of anti-metabolite agents and overall reduction in toxicity of therapy
• Acute neurotoxicity of methotrexate due to homocysteine and its metabolites
• Chronic neuropsychologic effects of anti-neoplastic therapy in children with leukemia
• Development of new and improved treatment approaches for children with brain tumors
• Study of neurocognitive function in children treated for ALL (Acute Lymphoblastic Leukemia)

                                                                    Zora R. Rogers, M.D.
Associate Professor of Pediatrics
Associate Director of the Sickle Cell Program

• Optimizing the clinical management of events in children with sickle cell disease (priapism, febrile illness, chest syndrome, painful crisis, avascular necrosis, stroke)
• Use of hydroxyurea, stem cell transplantation and other therapies, particularly in young children, to prevent the morbidity of sickle cell disease
• Natural history and intervention to ameliorate the morbidity of recurrent and prolonged priapism events in patients with sickle cell disease
• Optimization of chronic transfusion strategies for sickle cell disease and other hemoglobinopathies including erythrocytapheresis 

Victor Aquino, M.D.
Associate Professor of Pediatrics

• Emerging antibiotic resistance in viridans streptococcal bacteremia in children with cancer
• Phase I therapies to pediatric oncology patients with refractory or recurrent malignancies
• Safety and efficacy of once daily tobramycin and Timentin in febrile neutropenic children with cancer
• Evaluation of T cell immunity and reconstitution in patients with Hodgkin's lymphoma
• Use of inflammatory cytokines in the prediction of acute graft versus host disease
• Determination of the optimal prophylactic platelet dose strategy to prevent bleeding in thrombocytopenic patients

Robert Bash, M.D.
Associate Professor of Pediatrics

• End-of-life care, including hospice and bereavement
• Supportive care of pediatric cancer patients

                                                            Daniel Bowers, M.D.
Associate Professor of Pediatrics
Director, Neuro-Oncology Program

• Development of novel chemotherapy protocols for children with brain tumors and other solid tumors
• Reduction or prevention of neurocognitive injury for infants with brain tumors treated with craniospinal irradiation
• Evaluation of risk factors for stroke, impaired quality of life and other late effects in brain tumor survivors

                                                        Scott Cameron, M.D., Ph.D.
Assistant Professor of Pediatrics and Molecular Biology

• Genetic control of cell lineages and programmed cell death (apoptosis)

                                                        Charles Quinn, M.D.
Assistant Professor of Pediatrics

• Prevention and treatment of the acute and chronic complications of sickle cell disease
• Morbidity, mortality, and long-term outcome of sickle cell disease
• Novel causes of sickle cell pain
• Design and conduct of observational and experimental clinical research

                                                    Matthew Porteus, M.D., Ph.D.
Assistant Professor of Pediatrics and Cell Biology

• Developing gene targeting as a therapeutic tool for children with genetic diseases
• Understanding the regulation of DNA damage repair
• In vitro manipulation of hematopoietic stem cells
• Stem cell transplantation for genetic diseases
• Homologous recombination

Janna M. Journeycake, M.D.
Assistant Professor of Pediatrics
Associate Director of Hemophilia and Thrombosis Program

• Thrombotic and hemorrhagic disorders during childhood
• Catheter-related thrombosis in cancer and hemophilia patients

                                                    James F. Amatruda, M.D., Ph.D.
Assistant Professor of Pediatrics, Molecular Biology, and Internal Medicine

• Analysis of a novel zebrafish testicular cancer mutant
• Development of methods for gene inactivation in zebrafish
• Isolation of mutations interfering with the DNA damage response in zebrafish embryos

Jennifer A. Cox, M.D.
Assistant Professor of Pediatrics
Education Coordinator

• Reduced intensity conditioning hematopoietic cell transplantation for pediatric patients with hematologic malignancies at high risk for transplant-related mortality with standard transplantation

Jonathan E. Wickiser, M.D.
Assistant Professor of Pediatrics

• Prevention and treatment of chemotherapy induced nausea and vomiting
• Supportive care of pediatric oncology patients

Shelley E. Crary, M.D.
Assistant Professor of Pediatrics

• Pediatric disorders of thrombosis and Hemostasis
• Long-term complications of splenectomy
• Hereditary Spherocytosis and other non-malignant hematologic disorders

Kristine W. Appel, M.D.
Assistant Professor of Pediatrics

• Supportive care in pediatric oncology & hematology patients

Paul Harker-Murray, M.D., Ph.D.
Assistant Professor of Pediatrics

• Novel therapies for pediatric non-Hodgkin Lymphoma
• New drug development for pediatric patients with relapsed and refractory diseases
• Supportive care in pediatric oncology and hematopoietic cell transplantation

Cindy Neunert, M.D.
Assistant Professor of Pediatrics

• Assessment of outcomes in Immune Thrombocytopenic Purpura
• Pediatric disorders of hemostasis and coagulation

                                                                Tamra Slone, M.D.
Assistant Professor of Pediatrics

• Development & implementation of new treatments & supportive care strategies for children with Acute Lymphoblastic Leukemia
• Influence of hyperglycemia on the risk of infection during initial therapy in children with Acute Lymphoblastic Leukemia
• Infectious complications in children with Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia