2007:

Bushnaq, Z. I., Ashfaq, R., Leitch, A. M., and Euhus, D. Patient variables that predict atypical cytology by nipple duct lavage. Cancer, 109: 1247-1254, 2007.

Carter, D., Vazquez, M., Flieder, D. B., Brambilla, E., Gazdar, A., Noguchi, M., Travis, W. D., Kramer, A., Yip, R., Yankelevitz, D. F., and Henschke, C. I. Comparison of pathologic findings of baseline and annual repeat cancers diagnosed on CT screening. Lung Cancer, 2007.

Cho, C. H., Koh, Y. J., Han, J., Sung, H. K., Jong Lee, H., Morisada, T., Schwendener, R. A., Brekken, R. A., Kang, G., Oike, Y., Choi, T. S., Suda, T., Yoo, O. J., and Koh, G. Y. Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res, 100: e47-57, 2007.

Coyle, Y. M., Xie, X. J., Lewis, C. M., Bu, D., Milchgrub, S., and Euhus, D. M. Role of physical activity in modulating breast cancer risk as defined by APC and RASSF1A promoter hypermethylation in nonmalignant breast tissue. Cancer Epidemiol Biomarkers Prev, 16: 192-196, 2007.

Deng, W. G., Kawashima, H., Wu, G., Jayachandran, G., Xu, K., Minna, J. D., Roth, J. A., and Ji, L. Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent apoptotic pathway in human non-small cell lung cancer cells. Cancer Res, 67: 709-717, 2007.

Gazdar, A. F. DNA repair and survival in lung cancer--the two faces of Janus. N Engl J Med, 356: 771-773, 2007.

Gazdar, A. F. and Thun, M. J. Lung cancer, smoke exposure, and sex. J Clin Oncol, 25: 469-471, 2007.

Hirsch, F., Varella-Garcia, M., Cappuzzo, F., McCoy, J., Bemis, L., Xavier, A., Dziadziuszko, R., Gumerlock, P., Chansky, K., West, H., Gazdar, A., Crino, L., Gandara, D., Franklin, W., and Bunn, P., Jr. Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib. Ann Oncol, 18: 752-760, 2007.

Korpanty, G., Carbon, J. G., Grayburn, P. A., Fleming, J. B., and Brekken, R. A. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res, 13: 323-330, 2007.

Matsumoto, S., Iwakawa, R., Takahashi, K., Kohno, T., Nakanishi, Y., Matsuno, Y., Suzuki, K., Nakamoto, M., Shimizu, E., Minna, J. D., and Yokota, J. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene, 2007.

Reed, M. J., Karres, N., Eyman, D., Cruz, A., Brekken, R. A., and Plymate, S. The effects of aging on tumor growth and angiogenesis are tumor-cell dependent. Int J Cancer, 120: 753-760, 2007.

Sathyanarayana, U. G., Moore, A. Y., Li, L., Padar, A., Majmudar, K., Stastny, V., Makarla, P., Suzuki, M., Minna, J. D., Feng, Z., and Gazdar, A. F. Sun exposure related methylation in malignant and non-malignant skin lesions. Cancer Lett, 245: 112-120, 2007.

Sato, M., Shames, D. S., Gazdar, A. F., and Minna, J. D. A Translational View of the Molecular Pathogenesis of Lung Cancer. J Thorac Oncol, 2: 327-343, 2007.

Sato, N., Fukui, T., Taniguchi, T., Yokoyama, T., Kondo, M., Nagasaka, T., Goto, Y., Gao, W., Ueda, Y., Yokoi, K., Minna, J. D., Osada, H., Kondo, Y., and Sekido, Y. RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. Int J Cancer, 120: 543-551, 2007.

Shames, D. S., Minna, J. D., and Gazdar, A. F. DNA methylation in health, disease, and cancer. Curr Mol Med, 7: 85-102, 2007.

Shivapurkar, N., Stastny, V., Suzuki, M., Wistuba, II, Li, L., Zheng, Y., Feng, Z., Hol, B., Prinsen, C., Thunnissen, F. B., and Gazdar, A. F. Application of a methylation gene panel by quantitative PCR for lung cancers. Cancer Lett, 247: 56-71, 2007.

Suzuki, M., Shigematsu, H., Shames, D. S., Sunaga, N., Takahashi, T., Shivapurkar, N., Iizasa, T., Minna, J. D., Fujisawa, T., and Gazdar, A. F. Methylation and Gene Silencing of the Ras-Related GTPase Gene in Lung and Breast Cancers. Ann Surg Oncol, 14: 1397-1404, 2007.

Thomas, R. K., Baker, A. C., Debiasi, R. M., Winckler, W., Laframboise, T., Lin, W. M., Wang, M., Feng, W., Zander, T., Macconnaill, L. E., Lee, J. C., Nicoletti, R., Hatton, C., Goyette, M., Girard, L., Majmudar, K., Ziaugra, L., Wong, K. K., Gabriel, S., Beroukhim, R., Peyton, M., Barretina, J., Dutt, A., Emery, C., Greulich, H., Shah, K., Sasaki, H., Gazdar, A., Minna, J., Armstrong, S. A., Mellinghoff, I. K., Hodi, F. S., Dranoff, G., Mischel, P. S., Cloughesy, T. F., Nelson, S. F., Liau, L. M., Mertz, K., Rubin, M. A., Moch, H., Loda, M., Catalona, W., Fletcher, J., Signoretti, S., Kaye, F., Anderson, K. C., Demetri, G. D., Dummer, R., Wagner, S., Herlyn, M., Sellers, W. R., Meyerson, M., and Garraway, L. A. Corrigendum: High-throughput oncogene mutation profiling in human cancer. Nat Genet, 39: 567, 2007.

Thomas, R. K., Baker, A. C., Debiasi, R. M., Winckler, W., Laframboise, T., Lin, W. M., Wang, M., Feng, W., Zander, T., Macconnaill, L. E., Lee, J. C., Nicoletti, R., Hatton, C., Goyette, M., Girard, L., Majmudar, K., Ziaugra, L., Wong, K. K., Gabriel, S., Beroukhim, R., Peyton, M., Barretina, J., Dutt, A., Emery, C., Greulich, H., Shah, K., Sasaki, H., Gazdar, A., Minna, J., Armstrong, S. A., Mellinghoff, I. K., Hodi, F. S., Dranoff, G., Mischel, P. S., Cloughesy, T. F., Nelson, S. F., Liau, L. M., Mertz, K., Rubin, M. A., Moch, H., Loda, M., Catalona, W., Fletcher, J., Signoretti, S., Kaye, F., Anderson, K. C., Demetri, G. D., Dummer, R., Wagner, S., Herlyn, M., Sellers, W. R., Meyerson, M., and Garraway, L. A. High-throughput oncogene mutation profiling in human cancer. Nat Genet, 39: 347-351, 2007.

Wang, M., Vikis, H. G., Wang, Y., Jia, D., Wang, D., Bierut, L. J., Bailey-Wilson, J. E., Amos, C. I., Pinney, S. M., Petersen, G. M., de Andrade, M., Yang, P., Wiest, J. S., Fain, P. R., Schwartz, A. G., Gazdar, A., Minna, J., Gaba, C., Rothschild, H., Mandal, D., Kupert, E., Seminara, D., Liu, Y., Viswanathan, A., Govindan, R., Anderson, M. W., and You, M. Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. Cancer Res, 67: 93-99, 2007.

Whitehurst, A. W., Bodemann, B. O., Cardenas, J., Ferguson, D., Girard, L., Peyton, M., Minna, J. D., Michnoff, C., Hao, W., Roth, M. G., Xie, X. J., and White, M. A. Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature, 446: 815-819, 2007.

2006:

Agirre, X., Roman-Gomez, J., Jimenez-Velasco, A., Garate, L., Montiel-Duarte, C., Navarro, G., Vazquez, I., Zalacain, M., Calasanz, M. J., Heiniger, A., Torres, A., Minna, J. D., and Prosper, F. ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. Oncogene, 25: 1862-1870, 2006.

Agirre, X., Roman-Gomez, J., Vazquez, I., Jimenez-Velasco, A., Garate, L., Montiel-Duarte, C., Artieda, P., Cordeu, L., Lahortiga, I., Calasanz, M. J., Heiniger, A., Torres, A., Minna, J. D., and Prosper, F. Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. Int J Cancer, 118: 1945-1953, 2006.

Aoe, K., Hiraki, A., Murakami, T., Toyooka, S., Shivapurkar, N., Gazdar, A. F., Sueoka, N., Taguchi, K., Kamei, T., Takeyama, H., Sugi, K., and Kishimoto, T. Infrequent existence of simian virus 40 large T antigen DNA in malignant mesothelioma in Japan. Cancer Sci, 97: 292-295, 2006.

Beck, A. W., Luster, T. A., Miller, A. F., Holloway, S. E., Conner, C. R., Barnett, C. C., Thorpe, P. E., Fleming, J. B., and Brekken, R. A. Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice. Int J Cancer, 118: 2639-2643, 2006.

Bu, D., Tomlinson, G., Lewis, C. M., Zhang, C., Kildebeck, E., and Euhus, D. M. An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer. Breast Cancer Res Treat, 99: 257-265, 2006.

Chen, S., Iversen, E. S., Friebel, T., Finkelstein, D., Weber, B. L., Eisen, A., Peterson, L. E., Schildkraut, J. M., Isaacs, C., Peshkin, B. N., Corio, C., Leondaridis, L., Tomlinson, G., Dutson, D., Kerber, R., Amos, C. I., Strong, L. C., Berry, D. A., Euhus, D. M., and Parmigiani, G. Characterization of BRCA1 and BRCA2 mutations in a large United States sample. J Clin Oncol, 24: 863-871, 2006.

Chen, S., Wang, W., Lee, S., Nafa, K., Lee, J., Romans, K., Watson, P., Gruber, S. B., Euhus, D., Kinzler, K. W., Jass, J., Gallinger, S., Lindor, N. M., Casey, G., Ellis, N., Giardiello, F. M., Offit, K., and Parmigiani, G. Prediction of germline mutations and cancer risk in the Lynch syndrome. Jama, 296: 1479-1487, 2006.

Cler, L., Bu, D., Lewis, C., and Euhus, D. A comparison of five methods for extracting DNA from paucicellular clinical samples. Mol Cell Probes, 20: 191-196, 2006.

Coe, B. P., Lee, E. H., Chi, B., Girard, L., Minna, J. D., Gazdar, A. F., Lam, S., MacAulay, C., and Lam, W. L. Gain of a region on 7p22.3, containing MAD1L1, is the most frequent event in small-cell lung cancer cell lines. Genes Chromosomes Cancer, 45: 11-19, 2006.

Coe, B. P., Lockwood, W. W., Girard, L., Chari, R., Macaulay, C., Lam, S., Gazdar, A. F., Minna, J. D., and Lam, W. L. Differential disruption of cell cycle pathways in small cell and non-small cell lung cancer. Br J Cancer, 94: 1927-1935, 2006.

Coyle, Y. M., Minahjuddin, A. T., Hynan, L. S., and Minna, J. D. An Ecological Study of the Association of Metal Air Pollutants with Lung Cancer Incidence in Texas. J Thorac Oncol, 1: 654-661, 2006.

Das, A. K., Sato, M., Story, M. D., Peyton, M., Graves, R., Redpath, S., Girard, L., Gazdar, A. F., Shay, J. W., Minna, J. D., and Nirodi, C. S. Non-Small Cell Lung Cancers with Kinase Domain Mutations in the Epidermal Growth Factor Receptor Are Sensitive to Ionizing Radiation. Cancer Res, 66: 9601-9608, 2006.

Dowell, J. E. and Minna, J. D. EGFR mutations and molecularly targeted therapy: a new era in the treatment of lung cancer. Nat Clin Pract Oncol, 3: 170-171, 2006.

Drake, R. D., Rao, G. G., McIntire, D. D., Miller, D. S., and Schorge, J. O. Gestational trophoblastic disease among Hispanic women: a 21-year hospital-based study. Gynecol Oncol, 103: 81-86, 2006.

Esplin, E. D., Ramos, P., Martinez, B., Tomlinson, G. E., Mumby, M. C., and Evans, G. A. The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. Genes Chromosomes Cancer, 45: 182-190, 2006.

Euhus, D. M. Breast cancer prevention in the 21st century: defining the challenge. Breast J, 12: 97-98, 2006.

Flieder, D. B., Vazquez, M., Carter, D., Brambilla, E., Gazdar, A., Noguchi, M., Travis, W. D., Kramer, A., Yankelevitz, D. F., and Henschke, C. I. Pathologic findings of lung tumors diagnosed on baseline CT screening. Am J Surg Pathol, 30: 606-613, 2006.

Garnis, C., Lockwood, W. W., Vucic, E., Ge, Y., Girard, L., Minna, J. D., Gazdar, A. F., Lam, S., Macaulay, C., and Lam, W. L. High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH. Int J Cancer, 118: 1556-1564, 2006.

Gazdar, A. F. Rapid screening for EGFR mutations: pros and cons. Cancer J, 12: 17-18, 2006.

Helfrich, B. A., Raben, D., Varella-Garcia, M., Gustafson, D., Chan, D. C., Bemis, L., Coldren, C., Baron, A., Zeng, C., Franklin, W. A., Hirsch, F. R., Gazdar, A., Minna, J., and Bunn, P. A., Jr. Antitumor Activity of the Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor Gefitinib (ZD1839, Iressa) in Non-Small Cell Lung Cancer Cell Lines Correlates with Gene Copy Number and EGFR Mutations but not EGFR Protein Levels. Clin Cancer Res, 12: 7117-7125, 2006.

Heller, G., Fong, K. M., Girard, L., Seidl, S., End-Pfutzenreuter, A., Lang, G., Gazdar, A. F., Minna, J. D., Zielinski, C. C., and Zochbauer-Muller, S. Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas. Oncogene, 25: 959-968, 2006.

Hohenstein, B., Hausknecht, B., Boehmer, K., Riess, R., Brekken, R. A., and Hugo, C. P. Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man. Kidney Int, 69: 1654-1661, 2006.

Holloway, S. E., Beck, A. W., Shivakumar, L., Shih, J., Fleming, J. B., and Brekken, R. A. Selective blockade of vascular endothelial growth factor receptor 2 with an antibody against tumor-derived vascular endothelial growth factor controls the growth of human pancreatic adenocarcinoma xenografts. Ann Surg Oncol, 13: 1145-1155, 2006.

Iijima, H., Tomizawa, Y., Iwasaki, Y., Sato, K., Sunaga, N., Dobashi, K., Saito, R., Nakajima, T., Minna, J. D., and Mori, M. Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers. Int J Cancer, 118: 797-801, 2006.

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Nordsell, R., Shames, D. S., Minna, J. D., and Corey, D. R. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nat Struct Mol Biol, 13: 787-792, 2006.

Khatlani, T. S., Wislez, M., Sun, M., Srinivas, H., Iwanaga, K., Ma, L., Hanna, A. E., Liu, D., Girard, L., Kim, Y. H., Pollack, J. R., Minna, J. D., Wistuba, II, and Kurie, J. M. c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells. Oncogene, 2006.

Kim, M. S., Jeong, J., Majewski, T., Kram, A., Yoon, D. S., Zhang, R. D., Li, J. Z., Ptaszynski, K., Kuang, T. C., Zhou, J. H., Sathyanarayana, U. G., Tuziak, T., Johnston, D. A., Grossman, H. B., Gazdar, A. F., Scherer, S. E., Benedict, W. F., and Czerniak, B. Evidence for alternative candidate genes near RB1 involved in clonal expansion of in situ urothelial neoplasia. Lab Invest, 86: 175-190, 2006.

Kim, Y. H., Girard, L., Giacomini, C. P., Wang, P., Hernandez-Boussard, T., Tibshirani, R., Minna, J. D., and Pollack, J. R. Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification. Oncogene, 25: 130-138, 2006.

Lam, D., Girard, L., Suen, W.-S., Chung, L.-P., Tin, V. P., Lam, W. K., Minna, J. D., and Wong, M. Establishment and Expression Profiling of New Lung Cancer Cell Lines from Chinese Smokers and Life-time Never-Smokers. J Thorac Oncol, 1: 932-942, 2006.

Lewis, C. M., Herbert, B. S., Bu, D., Halloway, S., Beck, A., Shadeo, A., Zhang, C., Ashfaq, R., Shay, J. W., and Euhus, D. M. Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier. Breast Cancer Res Treat, 99: 103-115, 2006.

Liang, Y., Brekken, R. A., and Hyder, S. M. Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones. Endocr Relat Cancer, 13: 905-919, 2006.

Lu, J. Y. and Hofmann, S. L. Inefficient cleavage of palmitoyl-protein thioesterase (PPT) substrates by aminothiols: implications for treatment of infantile neuronal ceroid lipofuscinosis. J Inherit Metab Dis, 29: 119-126, 2006.

Meng, S., Tripathy, D., Shete, S., Ashfaq, R., Saboorian, H., Haley, B., Frenkel, E., Euhus, D., Leitch, M., Osborne, C., Clifford, E., Perkins, S., Beitsch, P., Khan, A., Morrison, L., Herlyn, D., Terstappen, L. W., Lane, N., Wang, J., and Uhr, J. uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues. Proc Natl Acad Sci U S A, 103: 17361-17365, 2006.

Moshnikova, A., Frye, J., Shay, J. W., Minna, J. D., and Khokhlatchev, A. V. The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway. J Biol Chem, 281: 8143-8152, 2006.

Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., Clark, L., Bayani, N., Coppe, J. P., Tong, F., Speed, T., Spellman, P. T., Devries, S., Lapuk, A., Wang, N. J., Kuo, W. L., Stilwell, J. L., Pinkel, D., Albertson, D. G., Waldman, F. M., McCormick, F., Dickson, R. B., Johnson, M. D., Lippman, M., Ethier, S., Gazdar, A., and Gray, J. W. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell, 10: 515-527, 2006.

Nozaki, M., Sakurai, E., Raisler, B. J., Baffi, J. Z., Witta, J., Ogura, Y., Brekken, R. A., Sage, E. H., Ambati, B. K., and Ambati, J. Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J Clin Invest, 116: 422-429, 2006.

Oh, J. H., Nandi, A., Gurnani, P., Knowles, L., Schorge, J., Rosenblatt, K. P., and Gao, J. X. Proteomic biomarker identification for diagnosis of early relapse in ovarian cancer. J Bioinform Comput Biol, 4: 1159-1179, 2006.

Robinson, J. D., Lam, C. Y., Minnix, J. A., Wetter, D. W., Tomlinson, G. E., Minna, J. D., Chen, T. T., and Cinciripini, P. M. The DRD2 TaqI-B polymorphism and its relationship to smoking abstinence and withdrawal symptoms. Pharmacogenomics J, 2006.

Santarelli, J. G., Udani, V., Yung, Y. C., Cheshier, S., Wagers, A., Brekken, R. A., Weissman, I., and Tse, V. Incorporation of bone marrow-derived Flk-1-expressing CD34 cells in the endothelium of tumor vessels in the mouse brain. Neurosurgery, 59: 374-382; discussion 374-382, 2006.

Sathyanarayana, U. G., Moore, A. Y., Li, L., Padar, A., Majmudar, K., Stastny, V., Makarla, P., Suzuki, M., Minna, J. D., Feng, Z., and Gazdar, A. F. Sun exposure related methylation in malignant and non-malignant skin lesions. Cancer Lett, 2006.

Sato, M., Vaughan, M. B., Girard, L., Peyton, M., Lee, W., Shames, D. S., Ramirez, R. D., Sunaga, N., Gazdar, A. F., Shay, J. W., and Minna, J. D. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res, 66: 2116-2128, 2006.

Sato, N., Fukui, T., Taniguchi, T., Yokoyama, T., Kondo, M., Nagasaka, T., Goto, Y., Gao, W., Ueda, Y., Yokoi, K., Minna, J. D., Osada, H., Kondo, Y., and Sekido, Y. RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. Int J Cancer, 2006.

Sekine, I., Minna, J. D., Nishio, K., Tamura, T., and Saijo, N. A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer. J Thorac Oncol, 1: 31-37, 2006.

Shames, D. S., Girard, L., Gao, B., Sato, M., Lewis, C. M., Shivapurkar, N., Jiang, A., Perou, C. M., Kim, Y. H., Pollack, J. R., Fong, K. M., Lam, C. L., Wong, M., Shyr, Y., Nanda, R., Olopade, O. I., Gerald, W., Euhus, D. M., Shay, J. W., Gazdar, A. F., and Minna, J. D. A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med, 3: e486, 2006.

Shames, D. S., Minna, J. D., and Gazdar, A. F. Methods for detecting DNA methylation in tumors: From bench to bedside. Cancer Lett, 2006.

Shigematsu, H. and Gazdar, A. F. Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer, 118: 257-262, 2006.

Sjoblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D., Leary, R. J., Ptak, J., Silliman, N., Szabo, S., Buckhaults, P., Farrell, C., Meeh, P., Markowitz, S. D., Willis, J., Dawson, D., Willson, J. K., Gazdar, A. F., Hartigan, J., Wu, L., Liu, C., Parmigiani, G., Park, B. H., Bachman, K. E., Papadopoulos, N., Vogelstein, B., Kinzler, K. W., and Velculescu, V. E. The consensus coding sequences of human breast and colorectal cancers. Science, 314: 268-274, 2006.

Suzuki, M., Shigematsu, H., Iizasa, T., Hiroshima, K., Nakatani, Y., Minna, J. D., Gazdar, A. F., and Fujisawa, T. Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer. Cancer, 106: 2200-2207, 2006.

Suzuki, M., Shigematsu, H., Shivapurkar, N., Reddy, J., Miyajima, K., Takahashi, T., Gazdar, A. F., and Frenkel, E. P. Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer. Cancer Lett, 2006.

Suzuki, M., Shigematsu, H., Shivapurkar, N., Reddy, J., Miyajima, K., Takahashi, T., Gazdar, A. F., and Frenkel, E. P. Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer. Cancer Lett, 242: 222-230, 2006.

Takahashi, K., Kohno, T., Ajima, R., Sasaki, H., Minna, J. D., Fujiwara, T., Tanaka, N., and Yokota, J. Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. Int J Oncol, 28: 321-328, 2006.

Takahashi, T., Shigematsu, H., Shivapurkar, N., Reddy, J., Zheng, Y., Feng, Z., Suzuki, M., Nomura, M., Augustus, M., Yin, J., Meltzer, S. J., and Gazdar, A. F. Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers. Int J Cancer, 118: 924-931, 2006.

Tam, I. Y., Chung, L. P., Suen, W. S., Wang, E., Wong, M. C., Ho, K. K., Lam, W. K., Chiu, S. W., Girard, L., Minna, J. D., Gazdar, A. F., and Wong, M. P. Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Clin Cancer Res, 12: 1647-1653, 2006.

Toyooka, S., Tokumo, M., Shigematsu, H., Matsuo, K., Asano, H., Tomii, K., Ichihara, S., Suzuki, M., Aoe, M., Date, H., Gazdar, A. F., and Shimizu, N. Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers. Cancer Res, 66: 1371-1375, 2006.

Tsao, A. S., Tang, X. M., Sabloff, B., Xiao, L., Shigematsu, H., Roth, J., Spitz, M., Hong, W. K., Gazdar, A., and Wistuba, I. Clinicopathologic characteristics of the EGFR gene mutation in non-small cell lung cancer. J Thorac Oncol, 1: 231-239, 2006.

Ueda, K., Kawashima, H., Ohtani, S., Deng, W. G., Ravoori, M., Bankson, J., Gao, B., Girard, L., Minna, J. D., Roth, J. A., Kundra, V., and Ji, L. The 3p21.3 Tumor Suppressor NPRL2 Plays an Important Role in Cisplatin-Induced Resistance in Human Non-Small-Cell Lung Cancer Cells. Cancer Res, 66: 9682-9690, 2006.

Vaughan, M. B., Ramirez, R. D., Wright, W. E., Minna, J. D., and Shay, J. W. A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation, 74: 141-148, 2006.

Wang, S. E., Narasanna, A., Perez-Torres, M., Xiang, B., Wu, F. Y., Yang, S., Carpenter, G., Gazdar, A. F., Muthuswamy, S. K., and Arteaga, C. L. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell, 10: 25-38, 2006.

Wingo, S. N., Knowles, L. M., Carrick, K. S., Miller, D. S., and Schorge, J. O. Retrospective cohort study of surgical staging for ovarian low malignant potential tumors. Am J Obstet Gynecol, 194: e20-22, 2006.

Wislez, M., Fujimoto, N., Izzo, J. G., Hanna, A. E., Cody, D. D., Langley, R. R., Tang, H., Burdick, M. D., Sato, M., Minna, J. D., Mao, L., Wistuba, I., Strieter, R. M., and Kurie, J. M. High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res, 66: 4198-4207, 2006.

Witta, S. E., Gemmill, R. M., Hirsch, F. R., Coldren, C. D., Hedman, K., Ravdel, L., Helfrich, B., Dziadziuszko, R., Chan, D. C., Sugita, M., Chan, Z., Baron, A., Franklin, W., Drabkin, H. A., Girard, L., Gazdar, A. F., Minna, J. D., and Bunn, P. A., Jr. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res, 66: 944-950, 2006.

Wood, L. D., Calhoun, E. S., Silliman, N., Ptak, J., Szabo, S., Powell, S. M., Riggins, G. J., Wang, T. L., Yan, H., Gazdar, A., Kern, S. E., Pennacchio, L., Kinzler, K. W., Vogelstein, B., and Velculescu, V. E. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Hum Mutat, 27: 1060-1061, 2006.

Zhang, C., Naftalis, E., and Euhus, D. Carcinogen-induced DNA double strand break repair in sporadic breast cancer. J Surg Res, 135: 120-128, 2006.

Zhou, B. B., Peyton, M., He, B., Liu, C., Girard, L., Caudler, E., Lo, Y., Baribaud, F., Mikami, I., Reguart, N., Yang, G., Li, Y., Yao, W., Vaddi, K., Gazdar, A. F., Friedman, S. M., Jablons, D. M., Newton, R. C., Fridman, J. S., Minna, J. D., and Scherle, P. A. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell, 10: 39-50, 2006.

2005:

Amann, J., Kalyankrishna, S., Massion, P. P., Ohm, J. E., Girard, L., Shigematsu, H., Peyton, M., Juroske, D., Huang, Y., Stuart Salmon, J., Kim, Y. H., Pollack, J. R., Yanagisawa, K., Gazdar, A., Minna, J. D., Kurie, J. M., and Carbone, D. P. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res, 65: 226-235, 2005.

Cappuzzo, F., Varella-Garcia, M., Shigematsu, H., Domenichini, I., Bartolini, S., Ceresoli, G. L., Rossi, E., Ludovini, V., Gregorc, V., Toschi, L., Franklin, W. A., Crino, L., Gazdar, A. F., Bunn, P. A., Jr., and Hirsch, F. R. Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients. J Clin Oncol, 23: 5007-5018, 2005.

Carbone, D. P., Ciernik, I. F., Kelley, M. J., Smith, M. C., Nadaf, S., Kavanaugh, D., Maher, V. E., Stipanov, M., Contois, D., Johnson, B. E., Pendleton, C. D., Seifert, B., Carter, C., Read, E. J., Greenblatt, J., Top, L. E., Kelsey, M. I., Minna, J. D., and Berzofsky, J. A. Immunization with mutant p53- and K-ras-derived peptides in cancer patients: immune response and clinical outcome. J Clin Oncol, 23: 5099-5107, 2005.

Cinciripini, P. M., Tsoh, J. Y., Wetter, D. W., Lam, C., de Moor, C., Cinciripini, L., Baile, W., Anderson, C., and Minna, J. D. Combined effects of venlafaxine, nicotine replacement, and brief counseling on smoking cessation. Exp Clin Psychopharmacol, 13: 282-292, 2005.

Coe, B. P., Henderson, L. J., Garnis, C., Tsao, M. S., Gazdar, A. F., Minna, J., Lam, S., Macaulay, C., and Lam, W. L. High-resolution chromosome arm 5p array CGH analysis of small cell lung carcinoma cell lines. Genes Chromosomes Cancer, 42: 308-313, 2005.

Dobbin, K. K., Beer, D. G., Meyerson, M., Yeatman, T. J., Gerald, W. L., Jacobson, J. W., Conley, B., Buetow, K. H., Heiskanen, M., Simon, R. M., Minna, J. D., Girard, L., Misek, D. E., Taylor, J. M., Hanash, S., Naoki, K., Hayes, D. N., Ladd-Acosta, C., Enkemann, S. A., Viale, A., and Giordano, T. J. Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays. Clin Cancer Res, 11: 565-572, 2005.

Dote, H., Toyooka, S., Tsukuda, K., Yano, M., Ota, T., Murakami, M., Naito, M., Toyota, M., Gazdar, A. F., and Shimizu, N. Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. Br J Cancer, 92: 1117-1125, 2005.

Dowell, J., Minna, J. D., and Kirkpatrick, P. Erlotinib hydrochloride. Nat Rev Drug Discov, 4: 13-14, 2005.

Dowell, J. E., Gazdar, A. F., Shigematsu, H., Herz, J., and Minna, J. D. Clinical and Biologic Implications of EGFR Mutations in Lung Cancer. In: H. Pass, D. H. Johnson, A. T. Turrisi, 3rd, D. P. Carbone, and J. D. Minna (eds.), Lung Cancer Principles and Practice, 3rd edition, pp. 172-177. Philadelphia: Lippincott Williams & Wilkins, 2005.

Dowell, J. E. and Minna, J. D. Chasing mutations in the epidermal growth factor in lung cancer. N Engl J Med, 352: 830-832, 2005.

Fleming, J. B., Shen, G. L., Holloway, S. E., Davis, M., and Brekken, R. A. Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy. Mol Cancer Res, 3: 413-423, 2005.

Fujimoto, N., Wislez, M., Zhang, J., Iwanaga, K., Dackor, J., Hanna, A. E., Kalyankrishna, S., Cody, D. D., Price, R. E., Sato, M., Shay, J. W., Minna, J. D., Peyton, M., Tang, X., Massarelli, E., Herbst, R., Threadgill, D. W., Wistuba, II, and Kurie, J. M. High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res, 65: 11478-11485, 2005.

Gazdar, A. F. and Minna, J. D. Inhibition of EGFR Signaling: All Mutations Are Not Created Equal. PLoS Med, 2: e377, 2005.

Grundy, P. E., Breslow, N. E., Li, S., Perlman, E., Beckwith, J. B., Ritchey, M. L., Shamberger, R. C., Haase, G. M., D'Angio, G. J., Donaldson, M., Coppes, M. J., Malogolowkin, M., Shearer, P., Thomas, P. R., Macklis, R., Tomlinson, G., Huff, V., and Green, D. M. Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol, 23: 7312-7321, 2005.

Guillaud, M., le Riche, J. C., Dawe, C., Korbelik, J., Coldman, A., Wistuba, II, Park, I. W., Gazdar, A., Lam, S., and MacAulay, C. E. Nuclear morphometry as a biomarker for bronchial intraepithelial neoplasia: correlation with genetic damage and cancer development. Cytometry A, 63: 34-40, 2005.

Haruki, N., Kawaguchi, K. S., Eichenberger, S., Massion, P. P., Gonzalez, A., Gazdar, A. F., Minna, J. D., Carbone, D. P., and Dang, T. P. Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro. J Med Genet, 42: 558-564, 2005.

Henderson, L. J., Coe, B. P., Lee, E. H., Girard, L., Gazdar, A. F., Minna, J. D., Lam, S., MacAulay, C., and Lam, W. L. Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small-cell lung carcinoma cells. Br J Cancer, 92: 1553-1560, 2005.

Heuze-Vourc'h, N., Liu, M., Dalwadi, H., Baratelli, F. E., Zhu, L., Goodglick, L., Pold, M., Sharma, S., Ramirez, R. D., Shay, J. W., Minna, J. D., Strieter, R. M., and Dubinett, S. M. IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. Biochem Biophys Res Commun, 333: 470-475, 2005.

Hirschman, B. A., Pollock, B. H., and Tomlinson, G. E. The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds. J Pediatr, 147: 263-266, 2005.

Holloway, S. E., Beck, A. W., Girard, L., Jaber, M. R., Barnett, C. C., Jr., Brekken, R. A., and Fleming, J. B. Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer. J Am Coll Surg, 200: 371-377, 2005.

Jakob, J., Nagase, S., Gazdar, A., Chien, M., Morozova, I., Russo, J. J., Nandula, S. V., Murty, V. V., Li, C. M., Tycko, B., and Parsons, R. Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line. Genes Chromosomes Cancer, 42: 372-383, 2005.

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Shames, D. S., Minna, J. D., and Corey, D. R. Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs. Nat Chem Biol, 1: 216-222, 2005.

Ji, L., Minna, J. D., and Roth, J. A. 3p21.3 Tumor Suppressor Cluster: Prospects for Translational Applications. Future Oncology, 1: 1-13, 2005.

Kishimoto, M., Kohno, T., Okudela, K., Otsuka, A., Sasaki, H., Tanabe, C., Sakiyama, T., Hirama, C., Kitabayashi, I., Minna, J. D., Takenoshita, S., and Yokota, J. Mutations and deletions of the CBP gene in human lung cancer. Clin Cancer Res, 11: 512-519, 2005.

Korpanty, G., Grayburn, P. A., Shohet, R. V., and Brekken, R. A. Targeting vascular endothelium with avidin microbubbles. Ultrasound Med Biol, 31: 1279-1283, 2005.

Kusy, S., Potiron, V., Zeng, C., Franklin, W., Brambilla, E., Minna, J., Drabkin, H. A., and Roche, J. Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene. Biochim Biophys Acta, 2005.

Lewis, C. M., Cler, L. R., Bu, D. W., Zochbauer-Muller, S., Milchgrub, S., Naftalis, E. Z., Leitch, A. M., Minna, J. D., and Euhus, D. M. Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk. Clin Cancer Res, 11: 166-172, 2005.

Lopez, J. I., Colby, T. V., and Gazdar, A. F. Current status of small peripheral adenocarcinomas of the lung and their importance to pathologists. Ann Diagn Pathol, 9: 115-122, 2005.

Maitra, A., Arking, D. E., Shivapurkar, N., Ikeda, M., Stastny, V., Kassauei, K., Sui, G., Cutler, D. J., Liu, Y., Brimble, S. N., Noaksson, K., Hyllner, J., Schulz, T. C., Zeng, X., Freed, W. J., Crook, J., Abraham, S., Colman, A., Sartipy, P., Matsui, S., Carpenter, M., Gazdar, A. F., Rao, M., and Chakravarti, A. Genomic alterations in cultured human embryonic stem cells. Nat Genet, 37: 1099-1103, 2005.

Makarla, P. B., Saboorian, M. H., Ashfaq, R., Toyooka, K. O., Toyooka, S., Minna, J. D., Gazdar, A. F., and Schorge, J. O. Promoter hypermethylation profile of ovarian epithelial neoplasms. Clin Cancer Res, 11: 5365-5369, 2005.

Minna, J. D. and Dowell, J. Erlotinib hydrochloride. Nat Rev Drug Discov, Suppl: S14-15, 2005.

Minna, J. D., Peyton, M. J., and Gazdar, A. F. Gefitinib versus cetuximab in lung cancer: round one. J Natl Cancer Inst, 97: 1168-1169, 2005.

Moreno, M., Pimentel, F., Gazdar, A. F., Wistuba, II, and Miquel, J. F. TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma. Ann Hepatol, 4: 192-199, 2005.

Patterson, A., Davis, H., Euhus, D., Neuhausen, S., Strong, L., and Tomlinson, G. Recruitment for breast cancer predisposition studies in an underserved african american population. Breast J, 11: 79-82, 2005.

Puolakkainen, P. A., Bradshaw, A. D., Brekken, R. A., Reed, M. J., Kyriakides, T., Funk, S. E., Gooden, M. D., Vernon, R. B., Wight, T. N., Bornstein, P., and Sage, E. H. SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges. J Histochem Cytochem, 53: 571-581, 2005.

Rakheja, D., Kapur, P., Tomlinson, G. E., and Margraf, L. R. Pediatric renal cell carcinomas with Xp11.2 rearrangements are immunoreactive for hMLH1 and hMSH2 proteins. Pediatr Dev Pathol, 8: 615-620, 2005.

Rakheja, D., Lian, F., Tomlinson, G. E., Ewalt, D. H., Schultz, R. A., and Margraf, L. R. Renal metanephric adenoma with previously unreported cytogenetic abnormalities: case report and review of the literature. Pediatr Dev Pathol, 8: 218-223, 2005.

Rebbeck, T. R., Friebel, T., Wagner, T., Lynch, H. T., Garber, J. E., Daly, M. B., Isaacs, C., Olopade, O. I., Neuhausen, S. L., van 't Veer, L., Eeles, R., Evans, D. G., Tomlinson, G., Matloff, E., Narod, S. A., Eisen, A., Domchek, S., Armstrong, K., and Weber, B. L. Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. J Clin Oncol, 23: 7804-7810, 2005.

Reddy, J., Shivapurkar, N., Takahashi, T., Parikh, G., Stastny, V., Echebiri, C., Crumrine, K., Zochbauer-Muller, S., Drach, J., Zheng, Y., Feng, Z., Kroft, S. H., McKenna, R. W., and Gazdar, A. F. Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors. Oncogene, 24: 732-736, 2005.

Santarelli, J. G., Udani, V., Yung, C. Y., Cheshier, S., Wagers, A., Brekken, R. A., Weissman, I., and Tse, V. Preuss Resident Research Award: bone marrow-derived Flk-1-expressing CD34 cells contribute to the endothelium of tumor vessels in mouse brain. Clin Neurosurg, 52: 384-388, 2005.

Sato, M., Takahashi, K., Nagayama, K., Arai, Y., Ito, N., Okada, M., Minna, J. D., Yokota, J., and Kohno, T. Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer. Genes Chromosomes Cancer, 2005.

Sekido, Y., Fong, K. M., and Minna, J. D. Molecular Biology of Lung Cancer. In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.), Cancer: Principles and Practice of Oncology, 7th edition, pp. 175-183. Philadelphia: Lippincott-Raven, 2005.

Sekine, I., Sato, M., Sunaga, N., Toyooka, S., Peyton, M., Parsons, R., Wang, W., Gazdar, A. F., and Minna, J. D. The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer. Oncogene, 2005.

Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, II, Fong, K. M., Lee, H., Toyooka, S., Shimizu, N., Fujisawa, T., Feng, Z., Roth, J. A., Herz, J., Minna, J. D., and Gazdar, A. F. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst, 97: 339-346, 2005.

Shigematsu, H., Suzuki, M., Takahashi, T., Miyajima, K., Toyooka, S., Shivapurkar, N., Tomlinson, G. E., Mastrangelo, D., Pass, H. I., Brambilla, E., Sathyanarayana, U. G., Czerniak, B., Fujisawa, T., Shimizu, N., and Gazdar, A. F. Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies. Int J Cancer, 113: 600-604, 2005.

Shigematsu, H., Takahashi, T., Nomura, M., Majmudar, K., Suzuki, M., Lee, H., Wistuba, II, Fong, K. M., Toyooka, S., Shimizu, N., Fujisawa, T., Minna, J. D., and Gazdar, A. F. Somatic Mutations of the HER2 Kinase Domain in Lung Adenocarcinomas. Cancer Res, 65: 1642-1646, 2005.

Shivapurkar, N., Stastny, V., Takahashi, T., Suzuki, M., Echebiri, C., Reddy, J., and Gazdar, A. F. Novel real-time PCR assay using a universal molecular marker for diagnosis of hematologic cancers. Int J Cancer, 116: 656-660, 2005.

Suzuki, M., Hao, C., Takahashi, T., Shigematsu, H., Shivapurkar, N., Sathyanarayana, U. G., Iizasa, T., Fujisawa, T., Hiroshima, K., and Gazdar, A. F. Aberrant methylation of SPARC in human lung cancers. Br J Cancer, 92: 942-948, 2005.

Suzuki, M., Shigematsu, H., Hiroshima, K., Iizasa, T., Nakatani, Y., Minna, J. D., Gazdar, A. F., and Fujisawa, T. Epidermal growth factor receptor expression status in lung cancer correlates with its mutation. Hum Pathol, 36: 1127-1134, 2005.

Suzuki, M., Shigematsu, H., Shames, D. S., Sunaga, N., Takahashi, T., Shivapurkar, N., Iizasa, T., Frenkel, E. P., Minna, J. D., Fujisawa, T., and Gazdar, A. F. DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers. Br J Cancer, 93: 1029-1037, 2005.

Suzuki, M., Shigematsu, H., Takahashi, T., Shivapurkar, N., Sathyanarayana, U. G., Iizasa, T., Fujisawa, T., and Gazdar, A. F. Aberrant methylation of Reprimo in lung cancer. Lung Cancer, 47: 309-314, 2005.

Suzuki, M., Toyooka, S., Shivapurkar, N., Shigematsu, H., Miyajima, K., Takahashi, T., Stastny, V., Zern, A. L., Fujisawa, T., Pass, H. I., Carbone, M., and Gazdar, A. F. Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection. Oncogene, 24: 1302-1308, 2005.

Swinney, R. M., Hsu, S. C., Hirschman, B. A., Chen, T. T., and Tomlinson, G. E. MDM2 promoter variation and age of diagnosis of acute lymphoblastic leukemia. Leukemia, 19: 1996-1998, 2005.

Takahashi, T., Suzuki, M., Shigematsu, H., Shivapurkar, N., Echebiri, C., Nomura, M., Stastny, V., Augustus, M., Wu, C. W., Wistuba, II, Meltzer, S. J., and Gazdar, A. F. Aberrant methylation of Reprimo in human malignancies. Int J Cancer, 2005.

Tang, X., Shigematsu, H., Bekele, B. N., Roth, J. A., Minna, J. D., Hong, W. K., Gazdar, A. F., and Wistuba, II EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. Cancer Res, 65: 7568-7572, 2005.

Tokumo, M., Toyooka, S., Kiura, K., Shigematsu, H., Tomii, K., Aoe, M., Ichimura, K., Tsuda, T., Yano, M., Tsukuda, K., Tabata, M., Ueoka, H., Tanimoto, M., Date, H., Gazdar, A. F., and Shimizu, N. The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers. Clin Cancer Res, 11: 1167-1173, 2005.

Tomizawa, Y., Iijima, H., Sunaga, N., Sato, K., Takise, A., Otani, Y., Tanaka, S., Suga, T., Saito, R., Ishizuka, T., Dobashi, K., Minna, J. D., Nakajima, T., and Mori, M. Clinicopathologic significance of the mutations of the epidermal growth factor receptor gene in patients with non-small cell lung cancer. Clin Cancer Res, 11: 6816-6822, 2005.

Tomlinson, G. E., Breslow, N. E., Dome, J., Guthrie, K. A., Norkool, P., Li, S., Thomas, P. R., Perlman, E., Beckwith, J. B., D'Angio, G. J., and Green, D. M. Rhabdoid tumor of the kidney in the National Wilms' Tumor Study: age at diagnosis as a prognostic factor. J Clin Oncol, 23: 7641-7645, 2005.

Tomlinson, G. E., Douglass, E. C., Pollock, B. H., Finegold, M. J., and Schneider, N. R. Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21. Genes Chromosomes Cancer, 44: 177-184, 2005.

Yano, M., Toyooka, S., Tsukuda, K., Dote, H., Ouchida, M., Hanabata, T., Aoe, M., Date, H., Gazdar, A. F., and Shimizu, N. Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers. Int J Cancer, 113: 59-66, 2005.

Yap, Y. L., Lam, D. C., Girard, L., Zhang, X. W., Hernandez, D., Gras, R., Wang, E., Chiu, S. W., Chung, L. P., Lam, W. K., Smith, D. K., Minna, J. D., Danchin, A., and Wong, M. P. Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays. Nucleic Acids Res, 33: 409-421, 2005.

Zabarovsky, E. R., Lerman, M. I., and Minna, J. D. Chromosome 3 Abnormaliaties in Lung Cancer. In: H. Pass, D. H. Johnson, A. T. Turrisi, 3rd, D. P. Carbone, and J. D. Minna (eds.), Lung Cancer Principles and Practice, 3rd edition, pp. 118-134. Philadelphia: Lippincott Williams & Wilkins, 2005.

Zhao, X., Weir, B. A., LaFramboise, T., Lin, M., Beroukhim, R., Garraway, L., Beheshti, J., Lee, J. C., Naoki, K., Richards, W. G., Sugarbaker, D., Chen, F., Rubin, M. A., Janne, P. A., Girard, L., Minna, J., Christiani, D., Li, C., Sellers, W. R., and Meyerson, M. Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res, 65: 5561-5570, 2005.

Zochbauer-Muller, S., Fong, K. M., Geradts, J., Xu, X., Seidl, S., End-Pfutzenreuter, A., Lang, G., Heller, G., Zielinski, C. C., Gazdar, A. F., and Minna, J. D. Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation. Oncogene, 24: 6249-6255, 2005.