2009:
Soh J, Okumura N, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, Chari R, Shames DS, Tang X, MacAulay C, Varella-Garcia M, Vooder T, Wistuba, II, Lam S, Brekken R, Toyooka S, Minna JD, Lam WL, Gazdar AF: Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. PLoS One 4:e7464, 2009
Arnold SA, Brekken RA: SPARC: a matricellular regulator of tumorigenesis. J Cell Commun Signal, 2009
Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M: SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 41:1238-42, 2009
Yanagisawa H, Schluterman MK, Brekken RA: Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. J Cell Commun Signal, 2009
Liu Y, Liu P, Wen W, James MA, Wang Y, Bailey-Wilson JE, Amos CI, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M: Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. Cancer Res 69:7844-50, 2009
Meng J, Peng H, Dai B, Guo W, Wang L, Ji L, Minna JD, Chresta CM, Smith PD, Fang B, Roth JA: High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886). Cancer Biol Ther 8, 2009
Ramos AH, Dutt A, Mermel C, Perner S, Cho J, Lafargue CJ, Johnson LA, Stiedl AC, Tanaka KE, Bass AJ, Barretina J, Weir BA, Beroukhim R, Thomas RK, Minna JD, Chirieac LR, Lindeman NI, Giordano T, Beer DG, Wagner P, Wistuba, II, Rubin MA, Meyerson M: Amplification of chromosomal segment 4q12 in non-small cell lung cancer. Cancer Biol Ther 8, 2009
Krishnaswamy S, Kanteti R, Duke-Cohan JS, Loganathan S, Liu W, Ma PC, Sattler M, Singleton PA, Ramnath N, Innocenti F, Nicolae DL, Ouyang Z, Liang J, Minna J, Kozloff MF, Ferguson MK, Natarajan V, Wang YC, Garcia JG, Vokes EE, Salgia R: Ethnic Differences and Functional Analysis of MET Mutations in Lung Cancer. Clin Cancer Res, 2009
Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP: Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dyn 238:2670-9, 2009
Gazdar AF: Personalized medicine and inhibition of EGFR signaling in lung cancer. N Engl J Med 361:1018-20, 2009
Gazdar AF: Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 28 Suppl 1:S24-31, 2009
Du L, Schageman JJ, Subauste MC, Saber B, Hammond SM, Prudkin L, Wistuba, II, Ji L, Roth JA, Minna JD, Pertsemlidis A: miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1. Mol Cancer Res 7:1234-43, 2009
Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J: Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med 15:1023-30, 2009
Chen TT, Rakheja D, Hung JY, Hornsby PJ, Tabaczewski P, Malogolowkin M, Feusner J, Miskevich F, Schultz R, Tomlinson GE: Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor. Pediatr Blood Cancer 53:1040-7, 2009
Schwarz RE, Konduri S, Awasthi N, Cafasso D, Schwarz MA: An antiendothelial combination therapy strategy to increase survival in experimental pancreatic cancer. Surgery 146:241-9, 2009
Lee P, van den Berg RM, Lam S, Gazdar AF, Grunberg K, McWilliams A, Leriche J, Postmus PE, Sutedja TG: Color fluorescence ratio for detection of bronchial dysplasia and carcinoma in situ. Clin Cancer Res 15:4700-5, 2009
Kao J, Salari K, Bocanegra M, Choi YL, Girard L, Gandhi J, Kwei KA, Hernandez-Boussard T, Wang P, Gazdar AF, Minna JD, Pollack JR: Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS One 4:e6146, 2009
Roland CL, Dineen SP, Lynn KD, Sullivan LA, Dellinger MT, Sadegh L, Sullivan JP, Shames DS, Brekken RA: Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts. Mol Cancer Ther 8:1761-71, 2009
Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE: Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 29:4467-83, 2009
Kim HJ, Soyombo AA, Tjon-Kon-Sang S, So I, Muallem S: The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic 10:1157-67, 2009
Matsuo Y, Campbell PM, Brekken RA, Sung B, Ouellette MM, Fleming JB, Aggarwal BB, Der CJ, Guha S: K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways. Mol Cancer Res 7:799-808, 2009
Brambilla E, Gazdar A: Pathogenesis of lung cancer signalling pathways: roadmap for therapies. Eur Respir J 33:1485-97, 2009
Blanco R, Iwakawa R, Tang M, Kohno T, Angulo B, Pio R, Montuenga LM, Minna JD, Yokota J, Sanchez-Cespedes M: A gene-alteration profile of human lung cancer cell lines. Hum Mutat 30:1199-206, 2009
Sos ML, Michel K, Zander T, Weiss J, Frommolt P, Peifer M, Li D, Ullrich R, Koker M, Fischer F, Shimamura T, Rauh D, Mermel C, Fischer S, Stuckrath I, Heynck S, Beroukhim R, Lin W, Winckler W, Shah K, LaFramboise T, Moriarty WF, Hanna M, Tolosi L, Rahnenfuhrer J, Verhaak R, Chiang D, Getz G, Hellmich M, Wolf J, Girard L, Peyton M, Weir BA, Chen TH, Greulich H, Barretina J, Shapiro GI, Garraway LA, Gazdar AF, Minna JD, Meyerson M, Wong KK, Thomas RK: Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J Clin Invest 119:1727-40, 2009
Ivanova MM, Mazhawidza W, Dougherty SM, Minna JD, Klinge CM: Activity and intracellular location of estrogen receptors alpha and beta in human bronchial epithelial cells. Mol Cell Endocrinol 305:12-21, 2009
Choi K, Ahn YH, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX, Kurie JM: Distinct biological roles for the notch ligands Jagged-1 and Jagged-2. J Biol Chem 284:17766-74, 2009
Arguello AA, Fischer SJ, Schonborn JR, Markus RW, Brekken RA, Eisch AJ: Effect of chronic morphine on the dentate gyrus neurogenic microenvironment. Neuroscience 159:1003-10, 2009
Gazdar AF, Minna JD: Multifocal lung cancers--clonality vs field cancerization and does it matter? J Natl Cancer Inst 101:541-3, 2009
Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, Seeger JM, Weiss J, Fischer F, Frommolt P, Michel K, Peifer M, Mermel C, Girard L, Peyton M, Gazdar AF, Minna JD, Garraway LA, Kashkar H, Pao W, Meyerson M, Thomas RK: PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res 69:3256-61, 2009
You M, Wang D, Liu P, Vikis H, James M, Lu Y, Wang Y, Wang M, Chen Q, Jia D, Liu Y, Wen W, Yang P, Sun Z, Pinney SM, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Rothman N, Petersen GM, de Andrade M, Wu Y, Cunningham JM, Wiest JS, Fain PR, Schwartz AG, Girard L, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW: Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clin Cancer Res 15:2666-74, 2009
Donnini S, Solito R, Monti M, Balduini W, Carloni S, Cimino M, Bampton ET, Pinon LG, Nicotera P, Thorpe PE, Ziche M: Prevention of ischemic brain injury by treatment with the membrane penetrating apoptosis inhibitor, TAT-BH4. Cell Cycle 8:1271-8, 2009
McMahon KA, Zajicek H, Li WP, Peyton MJ, Minna JD, Hernandez VJ, Luby-Phelps K, Anderson RG: SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. EMBO J 28:1001-15, 2009
Gandhi J, Zhang J, Xie Y, Soh J, Shigematsu H, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Varella-Garcia M, Minna JD, Gazdar AF: Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS ONE 4:e4576, 2009
Miura N, Sato R, Tsukamoto T, Shimizu M, Kabashima H, Takeda M, Takahashi S, Harada T, West JE, Drabkin H, Mejia JE, Shiota G, Murawaki Y, Virmani A, Gazdar AF, Oshimura M, Hasegawa J: A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT. BMC Mol Biol 10:5, 2009
Zhang W, Peyton M, Xie Y, Soh J, Minna JD, Gazdar AF, Frenkel EP: Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines. J Thorac Oncol 4:161-6, 2009
Kubo T, Yamamoto H, Lockwood WW, Valencia I, Soh J, Peyton M, Jida M, Otani H, Fujii T, Ouchida M, Takigawa N, Kiura K, Shimizu K, Date H, Minna JD, Varella-Garcia M, Lam WL, Gazdar AF, Toyooka S: MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors. Int J Cancer 124:1778-84, 2009
Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, Loewen G, Keith RL, Gazdar A: Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial. J Thorac Oncol 4:49-54, 2009
Awasthi N, Schwarz MA, Verma V, Cappiello C, Schwarz RE: Endothelial monocyte activating polypeptide II interferes with VEGF-induced proangiogenic signaling. Lab Invest 89:38-46, 2009
Bull Phelps SL, Carbon J, Miller A, Castro-Rivera E, Arnold S, Brekken RA, Lea JS: Secreted protein acidic and rich in cysteine as a regulator of murine ovarian cancer growth and chemosensitivity. Am J Obstet Gynecol 200:180 e1-7, 2009
Vazquez M, Carter D, Brambilla E, Gazdar A, Noguchi M, Travis WD, Huang Y, Zhang L, Yip R, Yankelevitz DF, Henschke CI: Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: Histopathologic features and their prognostic implications. Lung Cancer 64:148-154, 2009
Dineen SP, Roland CL, Toombs JE, Kelher M, Silliman CC, Brekken RA, Barnett CC, Jr.: The acellular fraction of stored platelets promotes tumor cell invasion. J Surg Res 153:132-7, 2009
Larsen JE, Spinola M, Gazdar AF, Minna JD: An overview of the molecular biology of lung cancer, in Pass HI, Carbone DP, Johnson DH, et al (eds): Lung Cancer: Principles and Practice (ed 4th). Philadelphia, Lippincott Williams & Wilkins, 2009
2008:
Dowell J, Minna JD: Small-cell lung cancer: translational research enroute to therapeutic advances. Oncology (Williston Park) 22:1493, 1495, 2008
Gazdar AF, Minna JD: Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops. Cancer Prev Res (Phila Pa) 1:156-60, 2008
Slack MD, Martinez ED, Wu LF, Altschuler SJ: Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A 105:19306-11, 2008
Dineen SP, Sullivan LA, Beck AW, Miller AF, Carbon JG, Mamluk R, Wong H, Brekken RA: The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer. BMC Cancer 8:352, 2008
Soares MM, King SW, Thorpe PE: Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases. Nat Med 14:1357-62, 2008
Pratilas CA, Hanrahan AJ, Halilovic E, Persaud Y, Soh J, Chitale D, Shigematsu H, Yamamoto H, Sawai A, Janakiraman M, Taylor BS, Pao W, Toyooka S, Ladanyi M, Gazdar A, Rosen N, Solit DB: Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer Res 68:9375-83, 2008
Deus HF, Stanislaus R, Behrens C, Wistuba, II, Minna JD, Garner HR, Swisher SG, Roth JA, Correa AM, Broom B, Coombes K, Almeida JS: Data Driven Semantic Integration of Translational Lung Cancer Research at MDAnderson Cancer Center. AMIA Annu Symp Proc:927, 2008
Sangaletti S, Di Carlo E, Gariboldi S, Miotti S, Cappetti B, Parenza M, Rumio C, Brekken RA, Chiodoni C, Colombo MP: Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis. Cancer Res 68:9050-9, 2008
Castro-Rivera E, Ran S, Brekken RA, Minna JD: Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer Res 68:8295-303, 2008
Shivapurkar N, Stastny V, Okumura N, Girard L, Xie Y, Prinsen C, Thunnissen FB, Wistuba, II, Czerniak B, Frenkel E, Roth JA, Liloglou T, Xinarianos G, Field JK, Minna JD, Gazdar AF: Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. Cancer Res 68:7448-56, 2008
Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M: Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst 100:1326-30, 2008
Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, Harsha HC, Sato M, Bader JS, Lash AE, Minna JD, Pandey A, Varmus HE: Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proc Natl Acad Sci U S A 105:14112-7, 2008
Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba, II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF: PIK3CA mutations and copy number gains in human lung cancers. Cancer Res 68:6913-21, 2008
Deus HF, Stanislaus R, Veiga DF, Behrens C, Wistuba, II, Minna JD, Garner HR, Swisher SG, Roth JA, Correa AM, Broom B, Coombes K, Chang A, Vogel LH, Almeida JS: A Semantic Web management model for integrative biomedical informatics. PLoS ONE 3:e2946, 2008
Xie Y, Minna JD: Predicting the future for people with lung cancer. Nat Med 14:812-3, 2008
Udugamasooriya DG, Dunham G, Ritchie C, Brekken RA, Kodadek T: The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues. Bioorg Med Chem Lett 18:5892-4, 2008
Marconescu A, Thorpe PE: Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells. Biochim Biophys Acta 1778:2217-24, 2008
Toyooka S, Matsuo K, Gazdar AF: DNA methylation in lung cancer. N Engl J Med 358:2513; author reply 2514, 2008
Dineen SP, Lynn KD, Holloway SE, Miller AF, Sullivan JP, Shames DS, Beck AW, Barnett CC, Fleming JB, Brekken RA: Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice. Cancer Res 68:4340-6, 2008
Udugamasooriya DG, Ritchie C, Brekken RA, Kodadek T: A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site. Bioorg Med Chem 16:6338-43, 2008
Euhus DM, Bu D, Milchgrub S, Xie XJ, Bian A, Leitch AM, Lewis CM: DNA methylation in benign breast epithelium in relation to age and breast cancer risk. Cancer Epidemiol Biomarkers Prev 17:1051-9, 2008
Majewski T, Lee S, Jeong J, Yoon DS, Kram A, Kim MS, Tuziak T, Bondaruk J, Park WS, Tang KS, Chung W, Shen L, Ahmed SS, Johnston DA, Grossman HB, Dinney CP, Zhou JH, Harris RA, Snyder C, Filipek S, Narod SA, Watson P, Lynch HT, Gazdar A, Bar-Eli M, Wu XF, McConkey DJ, Baggerly K, Issa JP, Benedict WF, Scherer SE, Czerniak B: Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. Lab Invest 88:694-721, 2008
Einhorn LH, Bonomi P, Bunn PA, Jr., Camidge DR, Carbone DP, Choy H, Dubinett SM, Gandara DR, Gaspar LE, Govindan R, Johnson DH, Minna JD, Scagliotti G, West HJ, Herbst RS: Summary report 7th Annual Targeted Therapies of the Treatment of Lung Cancer. J Thorac Oncol 3:545-55, 2008
Arnold S, Mira E, Muneer S, Korpanty G, Beck AW, Holloway SE, Manes S, Brekken RA: Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC. Exp Biol Med (Maywood) 233:860-73, 2008
Shivapurkar N, Stastny V, Xie Y, Prinsen C, Frenkel E, Czerniak B, Thunnissen FB, Minna JD, Gazdar AF: Differential Methylation of a Short CpG-Rich Sequence within Exon 1 of TCF21 Gene: A Promising Cancer Biomarker Assay. Cancer Epidemiol Biomarkers Prev 17:995-1000, 2008
Lockwood WW, Chari R, Coe BP, Girard L, Macaulay C, Lam S, Gazdar AF, Minna JD, Lam WL: DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers. Oncogene 27:4615-24, 2008
Udugamasooriya DG, Dineen SP, Brekken RA, Kodadek T: A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity. J Am Chem Soc 130:5744-52, 2008
Kim HJ, Li Q, Tjon-Kon-Sang S, So I, Kiselyov K, Soyombo AA, Muallem S: A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. EMBO J 27:1197-205, 2008
Whitehurst AW, Ram R, Shivakumar L, Gao B, Minna JD, White MA: The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells. Mol Cell Biol 28:3190-7, 2008
Jennewein M, Lewis MA, Zhao D, Tsyganov E, Slavine N, He J, Watkins L, Kodibagkar VD, O'Kelly S, Kulkarni P, Antich PP, Hermanne A, Rosch F, Mason RP, Thorpe PE: Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine. Clin Cancer Res 14:1377-85, 2008
Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba, II, Kurie JM: Pten Inactivation Accelerates Oncogenic K-ras-Initiated Tumorigenesis in a Mouse Model of Lung Cancer. Cancer Res 68:1119-1127, 2008
Kwei KA, Kim YH, Girard L, Kao J, Pacyna-Gengelbach M, Salari K, Lee J, Choi YL, Sato M, Wang P, Hernandez-Boussard T, Gazdar AF, Petersen I, Minna JD, Pollack JR: Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Oncogene 27:3635-40, 2008
Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED: A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Anal Biochem 375:237-248, 2008
Jagadeeswaran R, Surawska H, Krishnaswamy S, Janamanchi V, Mackinnon AC, Seiwert TY, Loganathan S, Kanteti R, Reichman T, Nallasura V, Schwartz S, Faoro L, Wang YC, Girard L, Tretiakova MS, Ahmed S, Zumba O, Soulii L, Bindokas VP, Szeto LL, Gordon GJ, Bueno R, Sugarbaker D, Lingen MW, Sattler M, Krausz T, Vigneswaran W, Natarajan V, Minna J, Vokes EE, Ferguson MK, Husain AN, Salgia R: Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. Cancer Res 68:132-42, 2008
Gao B, Xie XJ, Huang C, Shames DS, Chen TT, Lewis CM, Bian A, Zhang B, Olopade OI, Garber JE, Euhus DM, Tomlinson GE, Minna JD: RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers. Cancer Res 68:22-5, 2008
Prudkin L, Behrens C, Liu DD, Zhou X, Ozburn NC, Bekele BN, Minna JD, Moran C, Roth JA, Ji L, Wistuba, II: Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer. Clin Cancer Res 14:41-7, 2008
Eckstein N, Servan K, Girard L, Cai D, von Jonquieres G, Jaehde U, Kassack MU, Gazdar AF, Minna JD, Royer HD: Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells. J Biol Chem 283:739-50, 2008
Minna JD, Schiller J: Neoplasms of the Lung, in Kasper D, Fauci A, Longo DL, et al (eds): Harrison's Principles of Internal Medicine (ed 17th). New York, McGraw-Hill, 2008, pp 551-562
Lam S, Standish B, Baldwin C, McWilliams A, Leriche J, Gazdar A, Vitkin AI, Yang V, Ikeda N, Macaulay C: In vivo Optical Coherence Tomography Imaging of Preinvasive Bronchial Lesions. Clin Cancer Res 14:2006-11, 2008
Lin H, Feng Z, Yu Y, Zheng Y, Shivapurkar N, Gazdar AF: Application of multidimensional selective item response regression model for studying multiple gene methylation in SV40 oncogenic pathways
J. Amer. Statistical Assoc. 103:201-211, 2008
Soh J, Toyooka S, Ichihara S, Asano H, Kobayashi N, Suehisa H, Otani H, Yamamoto H, Ichimura K, Kiura K, Gazdar AF, Date H: Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung. J Thorac Oncol 3:340-7, 2008
2007:
Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S, Balak M, Chang WC, Yu CJ, Gazdar A, Pass H, Rusch V, Gerald W, Huang SF, Yang PC, Miller V, Ladanyi M, Yang CH, Pao W: MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 104:20932-7, 2007
Qiao X, Lu JY, Hofmann SL: Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory response. BMC Neurosci 8:95, 2007
Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, Harran P, Wang X: Autocrine TNFalpha Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis. Cancer Cell 12:445-456, 2007
Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba, II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M: Characterizing the cancer genome in lung adenocarcinoma. Nature 450:893-8, 2007
Jayachandran G, Sazaki JI, Nishizaki M, Xu K, Girard L, Minna JD, Roth JA, Ji L: Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch. Cancer Res 67:10379-10388, 2007
Martinez ED, Botos J, Dohoney KM, Geiman TM, Kolla SS, Olivera A, Qiu Y, Rayasam GV, Stavreva DA, Cohen-Fix O: Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition. EMBO Rep 8:977-81, 2007
Hittelman WN, Liu DD, Kurie JM, Lotan R, Lee JS, Khuri F, Ibarguen H, Morice RC, Walsh G, Roth JA, Minna J, Ro JY, Broxson A, Hong WK, Lee JJ: Proliferative changes in the bronchial epithelium of former smokers treated with retinoids. J Natl Cancer Inst 99:1603-12, 2007
Liang Y, Besch-Williford C, Brekken RA, Hyder SM: Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeutics. Cancer Res 67:9929-36, 2007
Sun S, Schiller JH, Spinola M, Minna JD: New molecularly targeted therapies for lung cancer. J Clin Invest 117:2740-50, 2007
Parmigiani G, Chen S, Iversen ES, Jr., Friebel TM, Finkelstein DM, Anton-Culver H, Ziogas A, Weber BL, Eisen A, Malone KE, Daling JR, Hsu L, Ostrander EA, Peterson LE, Schildkraut JM, Isaacs C, Corio C, Leondaridis L, Tomlinson G, Amos CI, Strong LC, Berry DA, Weitzel JN, Sand S, Dutson D, Kerber R, Peshkin BN, Euhus DM: Validity of models for predicting BRCA1 and BRCA2 mutations. Ann Intern Med 147:441-50, 2007
Chesler L, Goldenberg DD, Seales IT, Satchi-Fainaro R, Grimmer M, Collins R, Struett C, Nguyen KN, Kim G, Tihan T, Bao Y, Brekken RA, Bergers G, Folkman J, Weiss WA: Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma. Cancer Res 67:9435-42, 2007
Toyooka S, Matsuo K, Shigematsu H, Kosaka T, Tokumo M, Yatabe Y, Ichihara S, Inukai M, Suehisa H, Soh J, Kiura K, Fong KM, Lee H, Wistuba, II, Gazdar AF, Mitsudomi T, Date H: The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. Clin Cancer Res 13:5763-8, 2007
Sun S, Schiller JH, Gazdar AF: Lung cancer in never smokers--a different disease. Nat Rev Cancer 7:778-90, 2007
Storer K, Tu J, Karunanayaka A, Smee R, Short R, Thorpe P, Stoodley M: Coadministration of low-dose lipopolysaccharide and soluble tissue factor induces thrombosis after radiosurgery in an animal arteriovenous malformation model. Neurosurgery 61:604-10; discussion 610-1, 2007
Euhus DM, Bu D, Ashfaq R, Xie XJ, Bian A, Leitch AM, Lewis CM: Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk. Cancer Epidemiol Biomarkers Prev 16:1812-21, 2007
Ma AM, Bowling M, Leitch M, Rao R, Euhus DM: Primary breast tumor characteristics predicting aggressive nodal involvement. Am J Surg 194:474-6, 2007
Gorlov IP, Meyer P, Liloglou T, Myles J, Boettger MB, Cassidy A, Girard L, Minna JD, Fischer R, Duffy S, Spitz MR, Haeussinger K, Kammerer S, Cantor C, Dierkesmann R, Field JK, Amos CI: Seizure 6-like (SEZ6L) gene and risk for lung cancer. Cancer Res 67:8406-11, 2007
He J, Luster TA, Thorpe PE: Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids. Clin Cancer Res 13:5211-8, 2007
Padron D, Sato M, Shay JW, Gazdar AF, Minna JD, Roth MG: Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized. Cancer Res 67:7695-702, 2007
Nagayama K, Kohno T, Sato M, Arai Y, Minna JD, Yokota J: Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. Genes Chromosomes Cancer 46:1000-10, 2007
Lea JS, Sunaga N, Sato M, Kalahasti G, Miller DS, Minna JD, Muller CY: Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cells. Reprod Sci 14:20-8, 2007
Ohtani S, Iwamaru A, Deng W, Ueda K, Wu G, Jayachandran G, Kondo S, Atkinson EN, Minna JD, Roth JA, Ji L: Tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit non-small cell lung cancer growth by caspase-independent apoptosis and autophagy. Cancer Res 67:6293-303, 2007
Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA: An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. Proc Natl Acad Sci U S A 104:11832-7, 2007
Liu M, Yang SC, Sharma S, Luo J, Cui X, Peebles KA, Huang M, Sato M, Ramirez RD, Shay JW, Minna JD, Dubinett SM: EGFR Signaling is Required for TGF-{beta}1-mediated COX-2 Induction in Human Bronchial Epithelial Cells. Am J Respir Cell Mol Biol, 2007
Sekine I, Minna JD, Nishio K, Saijo N, Tamura T: Genes regulating the sensitivity of solid tumor cell lines to cytotoxic agents: a literature review. Jpn J Clin Oncol 37:329-36, 2007
Whitehurst B, Flister MJ, Bagaitkar J, Volk L, Bivens CM, Pickett B, Castro-Rivera E, Brekken RA, Gerard RD, Ran S: Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model. Int J Cancer 121:2181-91, 2007
Konduri S, Schwarz MA, Cafasso D, Schwarz RE: Androgen receptor blockade in experimental combination therapy of pancreatic cancer. J Surg Res 142:378-86, 2007
Das AK, Chen BP, Story MD, Sato M, Minna JD, Chen DJ, Nirodi CS: Somatic Mutations in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor (EGFR) Abrogate EGFR-Mediated Radioprotection in Non-Small Cell Lung Carcinoma. Cancer Res 67:5267-74, 2007
Shah JK, Garner HR, White MA, Shames DS, Minna JD: sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database. BMC Bioinformatics 8:178, 2007
Vikis H, Sato M, James M, Wang D, Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Viswanathan A, Govindan R, Minna J, Anderson MW, You M: EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Res 67:4665-70, 2007
Lam DC, Girard L, Ramirez R, Chau WS, Suen WS, Sheridan S, Tin VP, Chung LP, Wong MP, Shay JW, Gazdar AF, Lam WK, Minna JD: Expression of Nicotinic Acetylcholine Receptor Subunit Genes in Non-Small-Cell Lung Cancer Reveals Differences between Smokers and Nonsmokers. Cancer Res 67:4638-47, 2007
Lin J, Sun T, Ji L, Deng W, Roth J, Minna J, Arlinghaus R: Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1. Oncogene, 2007
Nomura M, Shigematsu H, Li L, Suzuki M, Takahashi T, Estess P, Siegelman M, Feng Z, Kato H, Marchetti A, Shay JW, Spitz MR, Wistuba, II, Minna JD, Gazdar AF: Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers. PLoS Med 4:e125, 2007
Whitehurst AW, Bodemann BO, Cardenas J, Ferguson D, Girard L, Peyton M, Minna JD, Michnoff C, Hao W, Roth MG, Xie XJ, White MA: Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 446:815-819, 2007
Sato M, Shames DS, Gazdar AF, Minna JD: A translational view of the molecular pathogenesis of lung cancer. J Thorac Oncol 2:327-43, 2007
Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, Macconnaill LE, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C, Greulich H, Shah K, Sasaki H, Gazdar A, Minna J, Armstrong SA, Mellinghoff IK, Hodi FS, Dranoff G, Mischel PS, Cloughesy TF, Nelson SF, Liau LM, Mertz K, Rubin MA, Moch H, Loda M, Catalona W, Fletcher J, Signoretti S, Kaye F, Anderson KC, Demetri GD, Dummer R, Wagner S, Herlyn M, Sellers WR, Meyerson M, Garraway LA: Corrigendum: High-throughput oncogene mutation profiling in human cancer. Nat Genet 39:567, 2007
Matsumoto S, Iwakawa R, Takahashi K, Kohno T, Nakanishi Y, Matsuno Y, Suzuki K, Nakamoto M, Shimizu E, Minna JD, Yokota J: Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 26:5911-8, 2007
Bushnaq ZI, Ashfaq R, Leitch AM, Euhus D: Patient variables that predict atypical cytology by nipple duct lavage. Cancer 109:1247-54, 2007
Hirsch F, Varella-Garcia M, Cappuzzo F, McCoy J, Bemis L, Xavier A, Dziadziuszko R, Gumerlock P, Chansky K, West H, Gazdar A, Crino L, Gandara D, Franklin W, Bunn P, Jr.: Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib. Ann Oncol 18:752-60, 2007
Gazdar AF: DNA repair and survival in lung cancer--the two faces of Janus. N Engl J Med 356:771-3, 2007
Shames DS, Minna JD, Gazdar AF: DNA methylation in health, disease, and cancer. Curr Mol Med 7:85-102, 2007
Coyle YM, Xie XJ, Lewis CM, Bu D, Milchgrub S, Euhus DM: Role of physical activity in modulating breast cancer risk as defined by APC and RASSF1A promoter hypermethylation in nonmalignant breast tissue. Cancer Epidemiol Biomarkers Prev 16:192-6, 2007
Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, Macconnaill LE, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C, Greulich H, Shah K, Sasaki H, Gazdar A, Minna J, Armstrong SA, Mellinghoff IK, Hodi FS, Dranoff G, Mischel PS, Cloughesy TF, Nelson SF, Liau LM, Mertz K, Rubin MA, Moch H, Loda M, Catalona W, Fletcher J, Signoretti S, Kaye F, Anderson KC, Demetri GD, Dummer R, Wagner S, Herlyn M, Sellers WR, Meyerson M, Garraway LA: High-throughput oncogene mutation profiling in human cancer. Nat Genet 39:347-351, 2007
Gazdar AF, Thun MJ: Lung cancer, smoke exposure, and sex. J Clin Oncol 25:469-71, 2007
Chng WJ, Loeb LA, Bielas JH, Strauss BS, Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber T, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: Limits to the human cancer genome project? Science 315:762b-6b, 2007
Konduri S, Schwarz RE: Estrogen receptor beta/alpha ratio predicts response of pancreatic cancer cells to estrogens and phytoestrogens. J Surg Res 140:55-66, 2007
Cantara S, Thorpe PE, Ziche M, Donnini S: TAT-BH4 counteracts Abeta toxicity on capillary endothelium. FEBS Lett 581:702-6, 2007
Cho CH, Koh YJ, Han J, Sung HK, Jong Lee H, Morisada T, Schwendener RA, Brekken RA, Kang G, Oike Y, Choi TS, Suda T, Yoo OJ, Koh GY: Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res 100:e47-57, 2007
Carter D, Vazquez M, Flieder DB, Brambilla E, Gazdar A, Noguchi M, Travis WD, Kramer A, Yip R, Yankelevitz DF, Henschke CI: Comparison of pathologic findings of baseline and annual repeat cancers diagnosed on CT screening. Lung Cancer, 2007
Wang M, Vikis HG, Wang Y, Jia D, Wang D, Bierut LJ, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Minna J, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Liu Y, Viswanathan A, Govindan R, Anderson MW, You M: Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. Cancer Res 67:93-9, 2007
Korpanty G, Carbon JG, Grayburn PA, Fleming JB, Brekken RA: Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res 13:323-30, 2007
Suzuki M, Shigematsu H, Shames DS, Sunaga N, Takahashi T, Shivapurkar N, Iizasa T, Minna JD, Fujisawa T, Gazdar AF: Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers. Ann Surg Oncol 14:1397-404, 2007
Robinson JD, Lam CY, Minnix JA, Wetter DW, Tomlinson GE, Minna JD, Chen TT, Cinciripini PM: The DRD2 TaqI-B polymorphism and its relationship to smoking abstinence and withdrawal symptoms. Pharmacogenomics J 7:266-274, 2007
Shames DS, Minna JD, Gazdar AF: Methods for detecting DNA methylation in tumors: From bench to bedside. Cancer Lett 251:187-198, 2007
Kiselyov K, Soyombo A, Muallem S: TRPpathies. J Physiol 578:641-53, 2007
Reed MJ, Karres N, Eyman D, Cruz A, Brekken RA, Plymate S: The effects of aging on tumor growth and angiogenesis are tumor-cell dependent. Int J Cancer 120:753-60, 2007
Sato N, Fukui T, Taniguchi T, Yokoyama T, Kondo M, Nagasaka T, Goto Y, Gao W, Ueda Y, Yokoi K, Minna JD, Osada H, Kondo Y, Sekido Y: RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. Int J Cancer 120:543-51, 2007
Khatlani TS, Wislez M, Sun M, Srinivas H, Iwanaga K, Ma L, Hanna AE, Liu D, Girard L, Kim YH, Pollack JR, Minna JD, Wistuba, II, Kurie JM: c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells. Oncogene 26:2658-66, 2007
Shivapurkar N, Stastny V, Suzuki M, Wistuba, II, Li L, Zheng Y, Feng Z, Hol B, Prinsen C, Thunnissen FB, Gazdar AF: Application of a methylation gene panel by quantitative PCR for lung cancers. Cancer Lett 247:56-71, 2007
Sathyanarayana UG, Moore AY, Li L, Padar A, Majmudar K, Stastny V, Makarla P, Suzuki M, Minna JD, Feng Z, Gazdar AF: Sun exposure related methylation in malignant and non-malignant skin lesions. Cancer Lett 245:112-20, 2007
Chen Y, De Marco MA, Graziani I, Gazdar AF, Strack PR, Miele L, Bocchetta M: Oxygen Concentration Determines the Biological Effects of NOTCH-1 Signaling in Adenocarcinoma of the Lung. Cancer Res 67:7954-9, 2007
Kennedy TC, McWilliams A, Edell E, Sutedja T, Downie G, Yung R, Gazdar A, Mathur PN: Bronchial intraepithelial neoplasia/early central airways lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 132:221S-233S, 2007
Shivapurkar N, Sherman ME, Stastny V, Echebiri C, Rader JS, Nayar R, Bonfiglio TA, Gazdar AF, Wang SS: Evaluation of candidate methylation markers to detect cervical neoplasia. Gynecol Oncol 107:549-53, 2007
Sun S, Schiller JH, Gazdar AF: Lung cancer in never smokers - a different disease. Nat Rev Cancer 7:778-90, 2007
Suzuki M, Shigematsu H, Nakajima T, Kubo R, Motohashi S, Sekine Y, Shibuya K, Iizasa T, Hiroshima K, Nakatani Y, Gazdar AF, Fujisawa T: Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer. Clin Cancer Res 13:6087-92, 2007
2006:
Agirre, X., Roman-Gomez, J., Jimenez-Velasco, A., Garate, L., Montiel-Duarte, C., Navarro, G., Vazquez, I., Zalacain, M., Calasanz, M. J., Heiniger, A., Torres, A., Minna, J. D., and Prosper, F. ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. Oncogene, 25: 1862-1870, 2006.
Agirre, X., Roman-Gomez, J., Vazquez, I., Jimenez-Velasco, A., Garate, L., Montiel-Duarte, C., Artieda, P., Cordeu, L., Lahortiga, I., Calasanz, M. J., Heiniger, A., Torres, A., Minna, J. D., and Prosper, F. Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. Int J Cancer, 118: 1945-1953, 2006.
Aoe, K., Hiraki, A., Murakami, T., Toyooka, S., Shivapurkar, N., Gazdar, A. F., Sueoka, N., Taguchi, K., Kamei, T., Takeyama, H., Sugi, K., and Kishimoto, T. Infrequent existence of simian virus 40 large T antigen DNA in malignant mesothelioma in Japan. Cancer Sci, 97: 292-295, 2006.
Beck, A. W., Luster, T. A., Miller, A. F., Holloway, S. E., Conner, C. R., Barnett, C. C., Thorpe, P. E., Fleming, J. B., and Brekken, R. A. Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice. Int J Cancer, 118: 2639-2643, 2006.
Bu, D., Tomlinson, G., Lewis, C. M., Zhang, C., Kildebeck, E., and Euhus, D. M. An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer. Breast Cancer Res Treat, 99: 257-265, 2006.
Chen, S., Iversen, E. S., Friebel, T., Finkelstein, D., Weber, B. L., Eisen, A., Peterson, L. E., Schildkraut, J. M., Isaacs, C., Peshkin, B. N., Corio, C., Leondaridis, L., Tomlinson, G., Dutson, D., Kerber, R., Amos, C. I., Strong, L. C., Berry, D. A., Euhus, D. M., and Parmigiani, G. Characterization of BRCA1 and BRCA2 mutations in a large United States sample. J Clin Oncol, 24: 863-871, 2006.
Chen, S., Wang, W., Lee, S., Nafa, K., Lee, J., Romans, K., Watson, P., Gruber, S. B., Euhus, D., Kinzler, K. W., Jass, J., Gallinger, S., Lindor, N. M., Casey, G., Ellis, N., Giardiello, F. M., Offit, K., and Parmigiani, G. Prediction of germline mutations and cancer risk in the Lynch syndrome. Jama, 296: 1479-1487, 2006.
Cler, L., Bu, D., Lewis, C., and Euhus, D. A comparison of five methods for extracting DNA from paucicellular clinical samples. Mol Cell Probes, 20: 191-196, 2006.
Coe, B. P., Lee, E. H., Chi, B., Girard, L., Minna, J. D., Gazdar, A. F., Lam, S., MacAulay, C., and Lam, W. L. Gain of a region on 7p22.3, containing MAD1L1, is the most frequent event in small-cell lung cancer cell lines. Genes Chromosomes Cancer, 45: 11-19, 2006.
Coe, B. P., Lockwood, W. W., Girard, L., Chari, R., Macaulay, C., Lam, S., Gazdar, A. F., Minna, J. D., and Lam, W. L. Differential disruption of cell cycle pathways in small cell and non-small cell lung cancer. Br J Cancer, 94: 1927-1935, 2006.
Coyle, Y. M., Minahjuddin, A. T., Hynan, L. S., and Minna, J. D. An Ecological Study of the Association of Metal Air Pollutants with Lung Cancer Incidence in Texas. J Thorac Oncol, 1: 654-661, 2006.
Das, A. K., Sato, M., Story, M. D., Peyton, M., Graves, R., Redpath, S., Girard, L., Gazdar, A. F., Shay, J. W., Minna, J. D., and Nirodi, C. S. Non-Small Cell Lung Cancers with Kinase Domain Mutations in the Epidermal Growth Factor Receptor Are Sensitive to Ionizing Radiation. Cancer Res, 66: 9601-9608, 2006.
Dowell, J. E. and Minna, J. D. EGFR mutations and molecularly targeted therapy: a new era in the treatment of lung cancer. Nat Clin Pract Oncol, 3: 170-171, 2006.
Drake, R. D., Rao, G. G., McIntire, D. D., Miller, D. S., and Schorge, J. O. Gestational trophoblastic disease among Hispanic women: a 21-year hospital-based study. Gynecol Oncol, 103: 81-86, 2006.
Esplin, E. D., Ramos, P., Martinez, B., Tomlinson, G. E., Mumby, M. C., and Evans, G. A. The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. Genes Chromosomes Cancer, 45: 182-190, 2006.
Euhus, D. M. Breast cancer prevention in the 21st century: defining the challenge. Breast J, 12: 97-98, 2006.
Flieder, D. B., Vazquez, M., Carter, D., Brambilla, E., Gazdar, A., Noguchi, M., Travis, W. D., Kramer, A., Yankelevitz, D. F., and Henschke, C. I. Pathologic findings of lung tumors diagnosed on baseline CT screening. Am J Surg Pathol, 30: 606-613, 2006.
Garnis, C., Lockwood, W. W., Vucic, E., Ge, Y., Girard, L., Minna, J. D., Gazdar, A. F., Lam, S., Macaulay, C., and Lam, W. L. High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH. Int J Cancer, 118: 1556-1564, 2006.
Gazdar, A. F. Rapid screening for EGFR mutations: pros and cons. Cancer J, 12: 17-18, 2006.
Helfrich, B. A., Raben, D., Varella-Garcia, M., Gustafson, D., Chan, D. C., Bemis, L., Coldren, C., Baron, A., Zeng, C., Franklin, W. A., Hirsch, F. R., Gazdar, A., Minna, J., and Bunn, P. A., Jr. Antitumor Activity of the Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor Gefitinib (ZD1839, Iressa) in Non-Small Cell Lung Cancer Cell Lines Correlates with Gene Copy Number and EGFR Mutations but not EGFR Protein Levels. Clin Cancer Res, 12: 7117-7125, 2006.
Heller, G., Fong, K. M., Girard, L., Seidl, S., End-Pfutzenreuter, A., Lang, G., Gazdar, A. F., Minna, J. D., Zielinski, C. C., and Zochbauer-Muller, S. Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas. Oncogene, 25: 959-968, 2006.
Hohenstein, B., Hausknecht, B., Boehmer, K., Riess, R., Brekken, R. A., and Hugo, C. P. Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man. Kidney Int, 69: 1654-1661, 2006.
Holloway, S. E., Beck, A. W., Shivakumar, L., Shih, J., Fleming, J. B., and Brekken, R. A. Selective blockade of vascular endothelial growth factor receptor 2 with an antibody against tumor-derived vascular endothelial growth factor controls the growth of human pancreatic adenocarcinoma xenografts. Ann Surg Oncol, 13: 1145-1155, 2006.
Iijima, H., Tomizawa, Y., Iwasaki, Y., Sato, K., Sunaga, N., Dobashi, K., Saito, R., Nakajima, T., Minna, J. D., and Mori, M. Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers. Int J Cancer, 118: 797-801, 2006.
Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Nordsell, R., Shames, D. S., Minna, J. D., and Corey, D. R. Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nat Struct Mol Biol, 13: 787-792, 2006.
Khatlani, T. S., Wislez, M., Sun, M., Srinivas, H., Iwanaga, K., Ma, L., Hanna, A. E., Liu, D., Girard, L., Kim, Y. H., Pollack, J. R., Minna, J. D., Wistuba, II, and Kurie, J. M. c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells. Oncogene, 2006.
Kim, M. S., Jeong, J., Majewski, T., Kram, A., Yoon, D. S., Zhang, R. D., Li, J. Z., Ptaszynski, K., Kuang, T. C., Zhou, J. H., Sathyanarayana, U. G., Tuziak, T., Johnston, D. A., Grossman, H. B., Gazdar, A. F., Scherer, S. E., Benedict, W. F., and Czerniak, B. Evidence for alternative candidate genes near RB1 involved in clonal expansion of in situ urothelial neoplasia. Lab Invest, 86: 175-190, 2006.
Kim, Y. H., Girard, L., Giacomini, C. P., Wang, P., Hernandez-Boussard, T., Tibshirani, R., Minna, J. D., and Pollack, J. R. Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification. Oncogene, 25: 130-138, 2006.
Lam, D., Girard, L., Suen, W.-S., Chung, L.-P., Tin, V. P., Lam, W. K., Minna, J. D., and Wong, M. Establishment and Expression Profiling of New Lung Cancer Cell Lines from Chinese Smokers and Life-time Never-Smokers. J Thorac Oncol, 1: 932-942, 2006.
Lewis, C. M., Herbert, B. S., Bu, D., Halloway, S., Beck, A., Shadeo, A., Zhang, C., Ashfaq, R., Shay, J. W., and Euhus, D. M. Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier. Breast Cancer Res Treat, 99: 103-115, 2006.
Liang, Y., Brekken, R. A., and Hyder, S. M. Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones. Endocr Relat Cancer, 13: 905-919, 2006.
Lu, J. Y. and Hofmann, S. L. Inefficient cleavage of palmitoyl-protein thioesterase (PPT) substrates by aminothiols: implications for treatment of infantile neuronal ceroid lipofuscinosis. J Inherit Metab Dis, 29: 119-126, 2006.
Martinez ED, Hager GL: Development of assays for nuclear receptor modulators using fluorescently tagged proteins. Methods Enzymol 414:37-50, 2006
Martinez ED, Dull AB, Beutler JA, Hager GL: High-content fluorescence-based screening for epigenetic modulators. Methods Enzymol 414:21-36, 2006
Meng, S., Tripathy, D., Shete, S., Ashfaq, R., Saboorian, H., Haley, B., Frenkel, E., Euhus, D., Leitch, M., Osborne, C., Clifford, E., Perkins, S., Beitsch, P., Khan, A., Morrison, L., Herlyn, D., Terstappen, L. W., Lane, N., Wang, J., and Uhr, J. uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues. Proc Natl Acad Sci U S A, 103: 17361-17365, 2006.
Moshnikova, A., Frye, J., Shay, J. W., Minna, J. D., and Khokhlatchev, A. V. The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway. J Biol Chem, 281: 8143-8152, 2006.
Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., Clark, L., Bayani, N., Coppe, J. P., Tong, F., Speed, T., Spellman, P. T., Devries, S., Lapuk, A., Wang, N. J., Kuo, W. L., Stilwell, J. L., Pinkel, D., Albertson, D. G., Waldman, F. M., McCormick, F., Dickson, R. B., Johnson, M. D., Lippman, M., Ethier, S., Gazdar, A., and Gray, J. W. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell, 10: 515-527, 2006.
Nozaki, M., Sakurai, E., Raisler, B. J., Baffi, J. Z., Witta, J., Ogura, Y., Brekken, R. A., Sage, E. H., Ambati, B. K., and Ambati, J. Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J Clin Invest, 116: 422-429, 2006.
Oh, J. H., Nandi, A., Gurnani, P., Knowles, L., Schorge, J., Rosenblatt, K. P., and Gao, J. X. Proteomic biomarker identification for diagnosis of early relapse in ovarian cancer. J Bioinform Comput Biol, 4: 1159-1179, 2006.
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