Professor • Post Docs • Technical Staff • Students • Join Our Lab
Qing Richard Lu, Ph.D.
Associate Professor, Department Developmental Biology
Eugene Mc Dermott Scholar in Biomedical Research, UT Southwestern
Personal Overview
Office: (214) 648-7410
FAX: (214) 648-7343
Building NB, Room 5.110
Email: QRichard.Lu@UTSouthwestern.edu
The central goal of our research is to understand the molecular mechanisms of neural cell fate specification and differentiation in the mammalian central nervous system (CNS). We are interested in the neural stem cell biology and cell fate specification. Using gliogenesis as a model for neural stem cell differentiation, we have identified a number of regulatory genes important for the formation of neurons and glial cells, the major cell types in the CNS.
Our current projects include:
- Transcriptional control of glial fate specification
- Signaling mechanisms of myelinogenesis in the CNS and PNS
- Epigenetic control of myelination
- Glial functions in neuronal development and disease
- Molecular mechanisms of brain tumor formation
Award & Honors:
Eugene Mc Dermott Scholar in Biomedical Research, UT Southwestern
Harry Weaver Neuroscience Scholar
Basil O Conner Scholar
Endowed Title:
Southwestern Medical Foundation Scholar in Biomedical Research
Schools:
Graduate School: Rutgers University-UMDNJ, Ph.D. Biochemistry (1997)
Graduate School: USTC/Chinese Academic Sinica, Institute of Chemistry (1991)
Undergraduate: Beijing Normal University, Biochemistry (1988)
Selected Publications:
1. Lu, QR, Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, CD and Rowitch, D. (2002) " Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection " CELL, 109, 75-86.
2. Lu, QR, Cai, L., Rowitch, D., Cepko, CL. and Stiles, CD. (2001) "Ectopic Expression of Olig1 Promotes Oligodendrocyte Formation and reduces Neuronal Survival in Developing Mouse Cortex" Nature Neuroscience., 4, 973-974.
3. Lu, QR, Park, J., Noll, E, Chan, JA, Alberta, J., Yuk, D., Alzamora, MG, Louis, DN, Stiles, CD, Rowitch, DH. and Black, PM. (2001) "Oligodendrocyte Lineage Genes (OLIG) as Molecular Markers for Human Glial Brain Tumors". Proc. Nat. Acad. Sci. USA , 98, 10851-10856.
4. Lu, QR, Yuk, D., Alberta, JA., Zhu, Z., Pawlitzky, I., Chan, J., McMahon, AP., Stiles, CD. and Rowitch, DH. (2000) “Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System” NEURON, 25, 317–329
5. Xin, M., T. Yue, Z. Ma, F. Wu, A. Gow, and Lu, QR. (2005) "Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice." J. Neurosci, 25,1354-1366.
6. Yue, T., Xian, K., Hurlock, E., Xin, M., Kernie, S., Parada, L.F. and Lu, QR (2006). “A Critical Role of Dorsal Progenitors for Cortical Myelination". J. of Neurosci., 26(4). 1275-1280.
7. Wang, S., Dulin, J., Wu, H., Hurlock, E., Lee, S., Jansson, K., and Lu, QR. (2006). "An Oligodendrocyte-Specific Zinc Finger Transcription Regulator Cooperates With Olig2 To
Promote Oligodendrocyte Differentiation" Development, 2006;133(17):3389-98.
8. Cai, J., Chen Y., Cai, W., Hurlock, E., Wu, H., Kernie, S. G., Parada L. F. and Lu, QR. (2007). " A Crucial Role For Olig2 In White Matter Astrocyte Development" Development,134, 1887-1899 (2007).
9. Chen, Y., V. Balasubramaniyan, M. Tallquist, J. Li and Lu, QR (2007) Isolation and Culture of Rat and Mouse Oligodendrocyte Precursor Cells. Nature Protocols, 2, 1044-1051, 2007.
10. Lu, QR., Balasubramaniyan, V. and Peru, R.L., (2007) "Oligodendrocyte Myelination in the Mammalian CNS" Functional Development and Embryology, 1 (2):117-128.
11. Peru RL, Mandrycky N, Nait-Oumesmar B, Lu QR. (2008) Paving the Axonal Highway: From Stem Cells to Myelin Repair. Stem Cell Rev. 4(4):304-18.
12. Chen,Y., Miles, D., Hoang, J., Shi, J., Kernie, S.G. and Lu, QR (2008). “The bHLH Gene Olig2 Is Required for Reactive Astrocyte Proliferation After Cortical Injury”. J. Neurosci. 2008, 28(43):10983-9.
13. Ye, F., Chen, Y., Hoang, J. Montgomery, R., Zhao, X., Bu, H., Taketo, M., van Es, J., Clevers, H., Hsieh, J., Bassel-Duby, R., Olson, E., and Lu, QR (2009) " Histone Deacetylases 1 and 2 Regulate Oligodendrocyte Differentiation By Disrupting b-Catenin TCF Interaction". Nat Neurosci. 2009 Jul;12(7):829-38.
14. Chen Y., Wu, H., Wang, S., Hu, T., Cai, J., Hoang, J., Escobar, SS., Arnett, HA., Trapp, BD., Karandikar, N., Hsieh, J. and Lu, QR (2009) “The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell-intrinsic timer of myelination” Nat. Neurosci. 2009 Nov;12(11):1398-406.
15. Zhao, X., He, X., Han, X., Yu, Y., Ye, F., Chen, Y., Hoang, T., Xu, X., Mi, Q.S., Xin, M., Wang, F., Appel, B. and Lu, Q.R., "MicroRNA-mediated control of oligodendrocyte differentiation" Neuron, 65:612-626, March 2010.
16. Chen Y, Wang H, Yoon SO, Xu X, Hottiger MO, Svaren J, Nave KA, Kim HA, Olson EN, Lu QR. "HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination" Nat Neurosci. 2011 Apr;14(4):437-41. Epub 2011 Mar 20.
To access any of the publications referenced on this website please visit http://www.ncbi.nlm.nih.gov/PubMed
