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Rita Perlingeiro, Ph.D.

Ph.D., University of Campinas, Brazil - 1997
Assistant Professor, Department of Developmental Biology

Office: (214) 645-5913
FAX: (214) 648-1960
Building ND, Room 5.124A
Email: Rita.Perlingeiro@UTSouthwestern.edu 

Regenerative medicine is the central focus of research in my laboratory. We are studying the self-renewal and differentiation properties of embryonic and adult stem cells.

Stem cell transplants and muscular dystrophy

We are investigating the therapeutic potential of stem cells to treat muscular dystrophies with a special interest in the autosomal dominant FSHD (facioscapulohumeral muscular dystrophy). We are currently testing a variety of stem cells (embryonic stem cells, umbilical cord blood stem cells, and adult bone marrow mesenchymal stem cells) for muscle differentiation potential, with a view towards developing a muscle regenerative therapy from the most appropriate source.

Hematopoietic and vascular development from hemangioblast precursors

The close association between endothelial cells and primitive hematopoietic precursors in the embryonic yolk sac, in addition to the fact that these precursors share several critical regulatory genes and antigenic markers suggest a common progenitor for both lineages (the hemangioblast). We are identifying and characterizing novel genes involved in embryonic hemangioblast development.

Selected Publications:

Darabi R, Gehlbach K, Bachoo RM, Kamath S, Osawa M, Kamm KE, Kyba M, Perlingeiro RCR, "Functional skeletal muscle regeneration from differentiating embryonic stem cells" Nat Med. 2008 Jan 20;[Epub ahead of print]. 

Perlingeiro RCR, (2007) “Endoglin is Required for Hemangioblast and Early Hematopoietic Development” Development, 2007 August:134(16):3041-8.

Gang EJ, Bosnakovski D, Figueiredo CA, Visser JW & Perlingeiro RCR, (2007) “SSEA-4 identifies mesenchymal stem cells from bone marrow” Blood, 109:1743-1751.

Perlingeiro RCR, Kyba M, Bodie S & Daley GQ, (2003) “A role for TPO in hemangioblast development” Stem Cells, 21:272-280.

Kyba M, Perlingeiro RCR & Daley GQ, (2002) “HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors” Cell, 109:29-37.

Perlingeiro RCR, Kyba M, & Daley GQ, (2001) “Clonal analyis of differentiating embryonic stem cells reveals a hematopoietic progenitor with primitive erythroid and adult lymphoid-myeloid potential” Development, 128:4597-4604.

 To access any of the publications referenced on this website please visit http://www.ncbi.nlm.nih.gov/PubMed