Publications
Mohan C, Morel L, Yu Y, Croker B, Tian X-H, Deng A, Wakeland, EK. (1997) Functional dissection of SLE pathogenesis using congenic mouse strains. J Immunol 158:6019-6028.
Mohan C, Morel L, Yang P, Deng A, Wakeland EK. (1997) Genetic dissection of SLE pathogenesis : Sle2 on murine chromosome 4 leads to B-cell hyperactivity. J Immunol 159:454-465.
Mohan C, Alas E, Morel L, Yang P, Wakeland EK. (1998). Genetic dissection of SLE pathogenesis: Sle1 on murine chromosome 1 leads to selective loss of tolerance to chromatin components. J Clin Invest 101:1362-1372.
Mohan C, Morel L, Yang P, Wakeland EK. (1998). Expansion of splenic B1-cells with strong antigen presenting capabilities in the NZM2410 lupus strain. Arthritis Rheum 41:1652-1662.
Sobel ES, Mohan C, Morel L, Schiffenbauer J, Wakeland EK. (1999). Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 on murine Chr 1 by bone marrow. J Immunol 162:2415-2421
Morel L, Mohan C, Schiffenbauer J, Rudofsky UH, Longmate JA, Sobel ES, Tian X-H, Wakeland EK. (1999). Complex inheritance of complex phenotypes in a murine model of lupus. Mam Genome 10:176-181.
Mohan C, Yu Y, Morel L, Yang P, Wakeland E.K. (1999). Genetic dissection of SLE pathogenesis: Sle3 impacts T-cell activation, differentiation and cell death. J Immunol 162:6492-6502.
Mohan C, Morel, L, Yang, P, Watanabe, H, Croker, B, Gilkeson, G, Wakeland EK. (1999). Genetic dissection of SLE pathogenesis: A recipe for nephrophilic autoantibodies. J Clin Invest 103:1685-1695.
Mohan C, Morel L, Wakeland EK. (1999). Genetic insights into murine lupus. In Lupus: Molecular and Cellular Pathogenesis. G.C. Tsokos and G. Kammer (eds.) Humana Press Pages 124-139.
Morel L, Croker BP, Blenman KR, Mohan C, Huang G, Gilkeson G, Wakeland EK. (2000). Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci 97:6670
Mohan C. (2000). Immunogenetic Origins of Lupus. Br Int Med J 2: 1-15
Mohan C, Liu F, Xie C, Williams R. (2001) Antisubnucleosome reactivities in SLE patients and their first degree relatives. Clin Exp Immunol 123:119-126.
Mohan C. (2001). Murine Lupus Genetics: Lessons Learned. Current Opinion in Rheumatology 13:352-360.
Xie S-K, Chang S, Yang P, Jacob C, Kaliyaperumal A, Datta SK, Mohan, C. (2001) Genetic contributions of SWR towards lupus nephritis. J Immunol 167:7150-7156.
Xie S, Chang S, Sedrak P, Kaliyaperumal A, Datta SK, Mohan C. (2002). Dominant NZB contributions to lupus in the (SWR X NZB)F1 model. Genes and Immunity 3: S13-S20.
Chen L, and Mohan C. (2002) Molecular Signatures of anti-ssDNA, anti-dsDNA, and anti-nucleosome autoantibody heavy chains. Mol Immunology 39: 333-347.
Shi X, Xie C, Kreska D, Richardson J, Mohan C. (2002) Genetic Dissection of SLE: Sle1 and Fas impact distinct pathways leading to lymphoproliferative autoimmunity. J Exp Med 196:281-292.
Xie C, Zhou XJ, and Mohan C. (2003) Enhanced susceptibility to nephritis in the lupus facilitating NZW strain. Arthritis Rheum 48:1080-1092.
Xie C, Zhou JX, and Mohan C. (2003) Enhanced susceptibility to nephritis in the lupus facilitating NZW strain. Arthritis Rheum 48:1080-1092.
Raman K, and Mohan C. (2003) Genetic underpinnings of autoimmunity – lessons from studies in arthritis, diabetes, lupus and multiple sclerosis. Curr Opin Immunol (In Press)
Xie, S and Mohan C. (2003) Divide and conquer - the power of congenic strains. Clin Immunol. YCLIM-5443.
Liang Z, Xie C, Chen C, Kreska D, Hsu K, Li L, Zhou X-J, and Mohan C. (2004) Pathogenic profiles and molecular signatures of ANAs derived from NZM2410 lupus mice. J Exp Med 199:381-398.
Patel R and Mohan C. PI3K/AKT signaling and systemic autoimmunity. 2005. Immunol Res 31(1):47-55.
Limaye N, and Mohan C. 2004. Pathogenicity of anti-DNA and anti-glomerular antibodies: weighing the evidence. Drug Discovery Today: Disease Models 1(4):395-403.
Xie C, and Mohan C. 2005. Genetic dissection of SLE pathogenesis. In Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, Springer International (In Press).
Henry T, and Mohan C. 2005. Lesson in lupus from congenic strains. Archivum Immunologiae et Therapiae Experimentalis. 53:207-212.
Xie S., Sharma R., Kaliyaperumal A., Datta SK., and C. Mohan. 2005. Genetics of lupus susceptibility in NZB/SWR hybrids - lessons from an intercross study. Arthritis Rheum 52(2):659-667.
Fu Y, Xie C, Yan M, Li Q, Lu C, and C Mohan. 2005. LPS-induced mesangial transcriptomics – evaluating the role of interferon regulatory factor-1. Kidney Int 67:1350-1361.
Chang S. and Mohan C. 2005. Identification of novel VH1/J558 immunoglobulin germline genes of C57BL/6 (Igh(b)) allotype. Molecular Immunology. 42(11):1293-1301.
Kumar K. R, Zhu J, Bhaskarabhatla M, Yan M, Mohan C. 2005. Enhanced expression of Ly-6A/E correlates with disease severity in various lupus prone mice. J. Autoimmunity 25:215-222.
Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, Wakeland EK, and Mohan C. 2005. Genetic dissection of lupus: T-cell hyperactivity as a consequence of hyperstimulatory antigen presenting cells. J Clin Invest 115(7):1869-1878.
Q Li, C Xie, C Putterman, C Mohan. 2005. Glomerular proteome arrays – a novel approach to study glomerular-reactive autoantibodies in lupus. J Clin Invest 115:3428-3439.
Li J, Liu Y, Xie C, Zhu J, Zhou XJ, C Mohan. 2005. Deficiency of Type I interferon contributes to Sle2-associated component lupus phenotypes. Arthritis Rheum 52:3063-3072.
Fu Y, Xie C, Chen J, Zhu J, Zhou H, Thomas J, Zhou XJ, Mohan C. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol. 2006 Jan 1;176(1):632-9.
Mehrad B, Park SJ, Akangire G, Standiford TJ, Wu T, Zhu J, Mohan C. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol. 2006 Mar 1;176(5):3233-9.
Kumar KR, Li L, Yan M, Bhaskarabhatla M, Mobley AB, Nguyen C, Mooney JM, Schatzle JD, Wakeland EK, Mohan C. Regulation of B cell tolerance by the lupus susceptibility gene ly108. Science. 2006 Jun 16;312(5780):1665-9.
Wu T, Qin X, Kurepa Z, Kumar KR, Liu K, Kanta H, Zhou XJ, Satterthwaite AB, Davis LS, Mohan C. Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus. J Clin Invest. 2007 Jul 19; [Epub ahead of print]
Fu Y, Du Y, Mohan C. Experimental anti-GBM disease as a tool for studying spontaneous lupus nephritis. Clin Immunol. 2007 Aug;124(2):109-18.
Liu Y, Li L, Kumar KR, Xie C, Lightfoot S, Zhou XJ, Kearney JF, Weigert M, Mohan C. Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells. J Immunol. 2007 Jul 15;179(2):1340-52.
Xie C, Qin X, Jonnala G, Gong Y, Yan M, Zong P, Zhou XJ, Mohan C. Enhanced susceptibility to immune nephritis in DBA/1 mice is contingent upon IL-1 expression. Clin Immunol. 2007 Jul;124(1):49-56.
Xie C, Patel R, Wu T, Zhu J, Henry T, Bhaskarabhatla M, Samudrala R, Tus K, Gong Y, Zhou H, Wakeland EK, Zhou XJ, Mohan C. PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr. Int Immunol. 2007 Apr;19(4):509-22.
Li L, Mohan C. Genetic basis of murine lupus nephritis. Semin Nephrol. 2007 Jan;27(1):12-21. Review.
Wu T, Xie C, Bhaskarabhatla M, Yan M, Leone A, Chen SS, Zhou XJ, Putterman C, Mohan C. Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significance. Arthritis Rheum. 2007 Mar;56(3):949-59.
Wu T, Mohan C. Proteomics on the diagnostic horizon: Lessons from rheumatology. Am J Med Sci. 2007 Jan;333(1):16-25. Review.
Culton DA, Nicholas MW, Bunch DO, Zhen QL, Kepler TB, Dooley MA, Mohan C, Nachman PH, Clarke SH. Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss. J Clin Immunol. 2007 Jan;27(1):53-68.
Wu T, Mohan C. Three pathogenic determinants in immune nephritis--anti-glomerular antibody specificity, innate triggers and host genetics. Front Biosci. 2007 Jan 1;12:2207-11.
