Skip to main content About News Giving All Departments Contact Us Site Map
 University of Texas Southwestern Medical School
 
Search       
Print Friendly  
spacer Home Education Research Patient Care Faculty & Administration Resource Careers
Medical School Graduate School of Biomedical Sciences Allied Health Sciences School Residencies & Fellowships Program Directory Students & Alumni Continuing Education
spacer | Home > Education > Graduate School >
UT Southwestern
MSTP Home

Publications of Current MSTP Fellows

APPLY NOW (MSTP) spacer
spacer
spacer
Search for Faculty
by Research Interests
 
 
Search for Faculty
by Name
 

bestGradSchool
 
 rss RSS        rss Podcast
spacer
 
 

Ables, Jessica (entered program 2005)
Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, DiLeone RJ, Greer CA, Mandyam CD, Eisch AJ: Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci 27(46): 12623-12629, 2007.

Astle, John (2003)
Astle J, Ferguson JT, German JB, Harrigan GG, Kelleher NL, Kodadek T, Parks BA, Roth MJ, Singletary KW, Wenger CD, Mahady GB: Characterization of proteomic and metabolomic responses to dietary factors and supplements. J Nutrition 137(12): 2787-2793, 2007.

Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O: Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.  J Biol Chem. 2004 Dec 24;279(52):54937-43. Epub 2004 Oct 12.

Atkin, Stan (2006)
Atkin SD, Patel S, Kocharyan A, Holtzclaw LA, Weerth SH, Schram V, Pickel J, Russell JT: Transgenic mice expressing a cameleon fluorescent Ca(2+) indicator in astrocytes and Schwann cells allow study of glial cell Ca(2+) signals in situ and in vivo.  J Neurosci Methods. 2009 May 16. [Epub ahead of print]

Benavides, David (2000)
Benavides DR, Quinn JJ, Zhong P, Hawasli AH, DiLeone RJ, Kansy JW, Olausson P, Yan Z, Taylor JR, Bibb JA: Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability. J Neurosci 27(47): 12967-12976, 2007.

Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA: Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci 10(7): 880-886, 2007.

Benavides DR, Bibb JA: Role of Cdk5 in drug abuse and plasticity.
Ann N Y Acad Sci. 1025: 335-344, 2004.

Bhoj, Elizabeth Keohane (2002)
Bhoj VG, Sun Q, Bhoj EJ, Somers C, Chen X, Torres JP, Mejias A, Gomez AM, Jafri H, Ramilo O, Chen ZJ: MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci USA 105(37): 14046-14051, 2008.

Bhoj, Vijay (2005)
Deng L, Dai P, Parikh T, Cao H, Bhoj V, Sun Q, Chen Z, Merghoub T, Houghton A, Shuman S: Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3. J Virol 82(21): 10734-10746, 2008.

Bhoj VG, Sun Q, Bhoj EJ, Somers C, Chen X, Torres JP, Mejias A, Gomez AM, Jafri H, Ramilo O, Chen ZJ: MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci USA 105(37): 14046-14051, 2008.

Bhoj VG, Chen ZJ: Linking retroelements to autoimmunity. Cell 134(4): 569-71, 2008.

Tennakoon DK, Mehta RS, Ortega SB, Bhoj V, Racke MK, Karandikar NJ:  Therapeutic induction of regulatory, cytotoxic CD8 T cells in multiple sclerosis.  J Immunol 176(11): 7119-7129, 2006.

Chen ZJ, Bhoj V, Seth RB:  Ubiquitin, TAK1 and IKK:  is there a connection?  Cell Death Differ 13(5): 687-692, 2006.

Bodemann, Brian (2004)
Bodemann BO, White MA: Ral GTPases and cancer: linchpin support of the tumorigenic platform. Cancer 8(2): 133-140, 2008.

Whitehurst AW, Bodemann BO, Cardenas J, Ferguson D, Girard L, Peyton M, Minna JD, Michnoff C, Hao W, Roth MG, Xie XJ, White MA: Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 446(7137): 815-819, 2007.

Etherton, Mark (2004)
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC: A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318(5847): 71-76, 2007.

Chubykin AA, Atasoy D, Etherton MR, Brose N, Kavalali ET, Gibson JR, Südhof TC: Activity-dependent validation of excitatory vs. inhibitory synapses by Neuroligin-1 vs. Neuroligin-2. Neuron 54(6): 919-931, 2007.

Evers, Bret (2004)
Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G: Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by Iovastatin. J Clin Invest 116(9): 2356-2365, 2006.

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS: Schoenheimer effect explained - - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest 115(9): 2489-2498, 2005.

Gocke, Christian (2001)
Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H: Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol 14(6): 535-539, 2007.

Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H: Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol 14(6): 535-539, 2007.

Kang J, Gocke CB, Yu H: Phosphorylation-facilitated symoylation of MEF2C negatively regulates its transcriptional activity. BMC Biochem 7:5, 2006.

Gocke CB, Yu H, Kang J: Systematic identification and analysis of mammalian SUMO substrates. J Biol Chem 280(6): 5004-5012, 2005.

Halford, Rebekkah Warren (2002)
Yildiz Y, Matern H, Thompson B, Allegood JC, Warren RL, Ramirez DM, Hammer RE, Hamra FK, Matern S, Russell DW: Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility. J Clin Invest 116(11): 2985-2994, 2006.

Hawasli, Ammar (2002)
Sahin B, Hawasli AH, Greene RW, Molkentin JD, Bibb JA: Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. Europ J Pharm 581(3): 270-275, 2008.

Benavides DR, Quinn JJ, Zhong P, Hawasli AH, DiLeone RJ, Kansy JW, Olausson P, Yan Z, Taylor JR, Bibb JA: Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability. J Neurosci 27(47): 12967-12976, 2007.

Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA: Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci, 2007 (Epub).

Hawasli AH, Bibb JA: Alternative roles for Cdk5 in learning and synaptic plasticity.
Biotechnol J, 2007 (Epub).

Infante, Rodney (2005)
Infante RE, Abi-Mosleh L, Radhakrishnan A, Dale JD, Brown MS, Goldstein JL: Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J Biol Chem 283(2): 1052-1063, 2008.

Infante RE, Radhakrishnan A, Abi-Mosleh L, Kinch LN, Wang ML, Grishin NV, Goldstein JL, Brown MS: Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J Biol Chem 283(2): 1064-1075, 2008.

Johnson, Cynthia (2001)
Keller BC, Johnson CL, Erickson AK, Gale M Jr: Innate immune evasion by hepatitis C virus and West Nile virus. Cytokine & Growth Factor Reviews 18(5-6): 535-544, 2007.

Johnson CL, Owen DM, Gale M Jr: Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense. J Biol Chem 282(14): 10792-10803, 2007.

Saito T, Harai R, Loo YM, Owen DM, Johnson CL, Sinha SC, Akira S, Fujita T, Gale M Jr: Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci USA 104(2): 582-587, 2007.

Chien Y, Kim S, Bumeister R, Loo YM, Kwon SW, Johnson CL, Balakireva MG, Romeo Y, Kopelovich L. Gale M JR, Yeaman C, Camonis JH, Zhao Y, White MA: RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell 127(1):157-70, 2007.

Loo YM, Owen DM, Li K, Erickson AK, Johnson CL, Fish PM, Carney DS, Wang T, Ishida H, Yoneyama M, Fujita T, Saito T, Lee WM, Hagedorn CH, Lau DT, Weinman SA, Lemon SM, Gale M Jr: Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci 103(15): 6001-6006, 2006.

Johnson CL, Gale M Jr: CARD games between virus and host get a new player. Trends Immunol 27(1): 1-4, 2006.

Foy E, Li K, Sumpter R Jr, Loo YM, Johnson CL, Wang C, Fish PM, Yoneyama M, Fujita T, Lemon SM, Gale M Jr: Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci USA 102(8): 2986-2991, 2005.

Keller, Brian (2001)
Daffis S, Samuel MA, Suthar MS, Keller BC, Gale M Jr, Diamond MS: Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J Virol 82(17): 8465-8475, 2008.

Fredericksen BL, Keller BC, Fornek J, Katze MG, Gale M Jr: Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1. J Virol 82(2): 609-616, 2008.

Keller BC, Johnson CL, Erickson AK, Gale M Jr: Innate immune evasion by hepatitis C virus and West Nile virus. Cytokine & Growth Factor Reviews 18(5-6): 535-544, 2007.

Daffis S, Samuel MA, Keller BC, Gale M JR, Diamond MS: Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and –independent mechanisms. PLoS Pathogens 3(7): e106, 2007.

Samuel MA, Whitby K, Keller BC, Marri A, Barchet W, Williams BR, Silverman RH, Gale M Jr, Diamond MS: PKR and RNase L contribute to protection against lethal West Nile virus infection by controlling early viral spread in the periphery and replication in neurons. J Virol 80(14): 7009-7019, 2006.

Keller BC, Fredericksen BL, Samuel AM, Mock RE, Mason PW, Diamond MS, Gale M Jr.: Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence. J Virol 80(19): 9424-9434, 2006.

Wang C, Gale M Jr, Keller BC, Huang H, Brown MS, Goldstein JL, Ye J: Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Mol Cell 18(4): 425-434, 2005.

Kildebeck, Eric (2005)
Bu D, Tomlinson G, Lewis CM, Zhang C, Kildebeck E, Euhus DM: An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer. Breast Cancer Res Treat 99(3): 257-265, 2006.

Krishnan, Vaishnav (2003)
Krishnan V, Nestler EJ: The molecular neurobiology of depression. Nature 455(7215): 894-902, 2008.

Kim KS, Lee KW, Baek IS, Lim CM, Krishnan V, Lee JK, Nestler EJ, Han PL: Adenylyl cyclas-5 activity in the nucleus accumbens regulates anxiety-related behavior. J Neurochem 107(1): 105-115, 2008.

Krishnan V, Graham A, Mazei-Robison MS, Lagace DC, Kim KS, Birnbaum S, Eisch AJ, Han PL, Storm DR, Zachariou V, Nestler EJ: Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting. Biol Psych 64(4): 336-343, 2008.

Krishnan V, Berton O, Nestler EJ: The use of animal models in psychiatric research and treatment. Amer J Psych 165(9): 1109, 2008.

Lutter M, Krishnan V, Russo SJ, Jung S, McClung CA, Nestler EJ: Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci 28(12): 3071-3075, 2008.

Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, LaPlant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ: Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131(2): 391-404, 2007.

Renthal W, Maze I, Krishnan V, Covington HE 3rd, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ: Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56(3): 517-529, 2007.

Berton O, Covington HE 3rd, Ebner K, Tsankova NM, Carle TL, Ulery P, Bohnsle A, Barrot M, Krishnan V, Singewald GM, Singewald N, Birnbaum S, Neve RL, Nestler EJ: Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responses. Neuron 55(2): 289-300, 2007.

Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA JR, McClung CA: Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA 104(15): 6406-6411, 2007.

Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ: Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311(5762): 864-868, 2006.

LaPlant, Quincey (2004)
Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, LaPlant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ: Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131(2): 391-404, 2007.

Zachariou V, Liu R, LaPlant Q, Xiao G, Renthal W, Chan GC, Storm DR, Aghajanian G, Nestler EJ: Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies. Biol Psych 63(11): 1013-1021, 2008.

Winstanley CA, LaPlant Q, Theobald DE, Green TA, Bachtell RK, Perrotti LI, DiLeone RJ, Russo SJ, Garth WJ, Self DW, Nestler EJ: DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J Neurosci 27(39): 10497-10507, 2007.

Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE 3rd, Sudhof T, Yu G: Nicastrin functions as a gamma-secretase-substrate receptor. Cell 122(3): 435-447, 2005.

Kumar A, Choi KH, Renthal W, Tsankova NM, Theobald DE, Truong HT, Russo SJ, LaPlant Q, Sasaki TS, Whistler KN, Neve RL, Self DW, Nestler EJ: Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48(2): 303-314, 2005.

Larson, Christopher (2000)
Shulman AI, Larson C, Mangelsdorf DJ, Ranganathan R.  Structural determinants of allosteric ligand activation in RXR heterodimers.  Cell. 2004 Feb 6;116(3):417-29. 

Lee, James (2000)
Lee J, Tomchick DR, Brautigam CA, Machius M, Kort R, Hellingwerf KH, Gardner KH: Changes at the KinA PAS-A dimerization interface influence histidine kinase function. Biochem 47(13): 4051-4064, 2008.

Li, Robert (2004)
Suh JM, Zeve D, McKay R, Seo J, Salo Z, Li R, Wang M, Graff JM: Adipose is a conserved dosage-sensitive antiobesity gene. Cell Metab 6(3): 195-207, 2007.

McNutt, Markey (2003)

Grefhorst A, McNutt MC, Lagace TA, Horton JD: Plasma PCSK9 preferentially reduces liver LDL receptors in mice. J Lipid Res 49(6): 1303-1311, 2008.

Kwon HJ, Lagace TA, McNutt MC, Horton JD, Deisenhofer J: Molecular basis for LDL receptor recognition by PCSK9. Proc Natl Acad Sci USA 105(6): 1820-1825, 2008.

McNutt MC, Lagace TA, Horton JD: Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells. J Biol Chem 282(29): 20799-20803, 2007.

McNutt MC, Lagace TA, Horton JD: Catalytic activity is not required for secreted PCSK9 to reduce LDL receptors in HepG2 cells. J Biol Chem 282(29): 20799-20803, 2007.

Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD: Secreted PCSK9 decreases the number of LDL receptors in heptocytes and in livers of parabiotic mice. J Clin Invest 116(11): 2995-3005, 2006.

Mellgren, Amy (2001)
Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD: Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res 103(12): 1393-1401, 2008.

Melton, Alexis (2002)
Topp JD, Jackson J, Melton AA, Lynch KW: A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4. Rna-A Pub, RNA Society 14(10): 2038-2049, 2008.

Melton AA, Jackson J, Wang J, Lynch KW: Combinatorial control of signal-induced exon repression by hnRNP L and PSF. Molec & Cell Biol 27(19): 6972-6984, 2007.

Meredith, David (2004)
Masui T, Swift GH, Hale MA, Meredith DM, Johnson JE, Macdonald RJ: Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. Molec & Cell Biol 28(17): 5458-5468, 2008.

Mishra, Prashant (2000)
Mishra P, Socolich M, Wall MA, Graves J, Wang Z, Ranganathan R: Dynamic scaffolding in a G protein-coupled signaling system. Cell 131(1): 80-92, 2007.

Russ WP, Lowery DM, Mishra P, Yaffe MB, Ranganathan R: Natural-like function in artificial WW domains. Nature 437(7058): 579-583, 2005.

Nash, Abigail (2003)
Ko WH, Nash AI, Gardner KH: A LOVely view of blue light photosensing. Nature Chem Biol 3(7): 372-374, 2007.

Nguyen, Baochan (Chan) (2001)
Nguyen C, Hosokawa T, Kuroiwa M, Ip NY, Nishi A, Hisanaga S, Bibb JA: Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization. J Neurochem 103(4): 1582-1593, 2007.

Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA: Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci 10(7): 880-886, 2007.

Nguyen C, Nishi A, Kansy JW, Fernandez J, Hayashi K, Gillardon F, Hemmings HC Jr, Nairn AC, Bibb JA: Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5. J Biol Chem 282(220): 16511-16520, 2007.

Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA: Cdk5 governs learning, memory and synaptic plasticity via NMDA receptors. Submitted to Nature August 2006.

Wei F-Y, Tomizawa K, Ohshima T, Asad A, Saito T, Nguyen C, Bibb JA, Ishiguro K, Kulkarni AB, Pant HC, Mikoshiba K, Matsui H, Hisanaga S: Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability. J Neurochemistry 93: 502-512, 2005.

Kansy JW, Daubner SC, Nishi A, Sotogaku N, Lloyd MD, Nguyen C, Lu L, Haycock JW, Hope BT, Fitzpatrick PF, Bibb JA: Identification of tyrosine hydroxylase as a physiological substrate for Cdk5. J Neurochem 91(2): 374-384, 2004.

Nguyen C, Bibb JA: Cdk5 and the mystery of synaptic vesicle endocytosis. J Cell Biol 163(4): 697-699, 2003.

Orvedahl, Anthony (2004)
Orvedahl A, Levine B: Autophagy and viral neurovirulence. Cell Microbiol 10(9): 1747-1756, 2008.

Orvedahl A, Levine B: Viral evasion of autophagy. Autophagy 4(3): 280-285, 2008.

He C, Orvedahl A: 2007 Keystone Symposium on Autophagy in Health and Disease. Autophagy 3(5): 527-536, 2007.

Orvedahl A, Alexander D, Tallóczy Z, Sun Q, Wei Y, Zhang W, Burns D, Leib DA, Levine B: HSV-1 ICP34.5 confers neurovirulence by targeting the beclin 1 autophagy protein. Cell Host & Microbe 1(1): 23-35, 2007.

Owen, David (2003)
Saito T, Owen DM, Jiang F, Marcotrigiano J, Gale M Jr: innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA: Nature 454(7203): 523-527, 2008.

Lau DT, Fish PM, Sinha M, Owen DM, Lemon DM, Gale M Jr: Interferon regulatory factor-3 activation, hepatic interferon-stimulated gene expression, and immune cell infiltration in hepatitis C virus patients. Hepatology 47(3): 799-809, 2008.

Huang H, Sun F, Owen DM, Li W, Chen Y, Gale M Jr, Ye J: Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins. Proc Natl Acad Sci USA 104(14): 5848-5853, 2007.

Johnson CL, Owen DM, Gale M Jr: Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense. J Biol Chem 282(14): 10792-10803, 2007.

Saito T, Harai R, Loo YM, Owen DM, Johnson CL, Sinha SC, Akira S, Fujita T, Gale M Jr: Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci USA 104(2): 582-587, 2007.

Loo YM, Owen DM, Li K, Erickson AK, Johnson CL, Fish PM, Carney DS, Wang T, Ishida H, Yoneyama M, Fujita T, Saito T, Lee WM, Hagedorn CH, Lau DT, Weinman SA, Lemon SM, Gale M Jr: Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci 103(15): 6001-6006, 2006.

Park, Joseph (2001)
Liu X, Park JK, Jiang F, Liu Y, McKearin D, Liu Q: Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes. Rna-A Pub, RNA Society 13(12): 2324-2329, 2007.

Maines JZ, Park JK, Williams M, McKearin DM: Stonewalling Drosophila stem cell differentiation by epigenetic controls. Development 134(8): 1471-1479, 2007.

Park JK, Liu X, Strauss TJ, McKearin DM, Liu Q: The miRNA pathway intrinsically controls self-renewal of drosophila germline stem cells. Curr Biol 17(6): 533-538, 2007.

Paulson, Vera (2005)
Jackson SR, Zhu CH, Paulson V, Watkins L, Dikmen ZG, Gryaznov SM, Wright WE, Shay JW: Antiadhesive effects of GRN163L – an oligonucleotide N3’->P5’ thio-phosphoramidate targeting telomerase. Cancer Res 67(3): 1121-1129, 2007.

Poole, Alan (2002)
Poole AM, Ranganathan R: Knowledge-based potentials in protein design. Curr Opin Struct Biol 16(4): 508-513, 2006.

Rasar Young, Melissa (2001)
Rasar MA, Hammes SR: The physiology of the Xenopus laevis ovary. Meth Molec Biol 322:17-30, 2006.

Rasar M, DeFranco DB, Hammes SR: Paxillin regulates steroid-triggered meiotic resumption in oocytes by enhancing an all-or-none positive feedback kinase loop. J Biol Chem 281(51); 39455-39464, 2006.

Haas D, White SN, Lutz LB, Rasar M, Hammes SR: The modulator of nongenomic actions of the estrogen receptor (MNAR) regulates transcription-independent androgen receptor-mediated signaling: evidence that MNAR participates in G protein-regulated meiosis in Xenopus laevis oocytes. Mol Endocrinol 19(8): 2035-2046, 2005.

Renthal, Nora Edwards (2004)
Russo SJ, Bolanos CA, Theobald DE, Decarolis N, Renthal W, Kumar A, Winstanley CA, Renthal NE, Wiley MD, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ: IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nature Neurosci 10: 93-99, 2006.

Renthal, William (2003)
Renthal W, Nestler EJ: Epigenetic mechanisms in drug addiction. Trends in Molec Med 14(8): 341-350, 2008.

Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A, Russo SJ, Sikder D, Dewey CM, David MM, Greengard P, Nairn AC, Nestler EJ, Cowan CW: Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59(4): 621-633, 2008.

Renthal W, Carle TL, Maze I, Covington HE 3rd, Truong HT, Alibhai I, Kumar A, Montgomery TL, Olson EN, Nestler EJ: Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci 28(29): 7344-7349, 2008.

Zachariou V, Liu R, LaPlant Q, Xiao G, Renthal W, Chan GC, Storm DR, Aghajanian G, Nestler EJ: Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies. Biol Psych 63(11): 1013-1021, 2008.

Perrotti LI, Weaver RR, Robison B, Renthal W, Maze I, Yazdani S, Elmore RG, Knapp DJ, Selley DE, Martin BR, Sim-Selley L, Bachtell RK, Self DW, Nestler EJ: Distinct patterns of DeltaFosB induction in brain by drugs of abuse. Synpase 62(5): 358-369, 2008.

Renthal W, Maze I, Krishnan V, Covington HE 3rd, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ: Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56(3): 517-529, 2007.

Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, LaPlant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ: Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131(2): 391-404, 2007.

Tsankova NM, Renthal W, Kumar A, Nestler EJ: Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 8(5): 355-367, 2007.

Russo SJ, Bolanos CA, Theobald DE, Decarolis N, Renthal W, Kumar A, Winstanley CA, Renthal NE, Wiley MD, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ: IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nature Neurosci 10: 93-99, 2006.

Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ: Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9(4): 519-525, 2006.

Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ: Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311(5762): 864-868, 2006.

Colvis CM, Pollock JD, Goodman RH, Impey S, Dunn J, Mandel G, Champagne FA, Mayford M, Korzus E, Kumar A, Renthal W, Theobald DE, Nestler EJ: Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45): 10379-10389, 2005.

Kumar A, Choi KH, Renthal W, Tsankova NM, Theobald DE, Truong HT, Russo SJ, LaPlant Q, Sasaki TS, Whistler KN, Neve RL, Self DW, Nestler EJ: Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48(2): 303-314, 2005.

Willie JT, Renthal W, Chemelli RM, Miller MS, Scammell TE, Yanagisawa M, Sinton CM: Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. Neuroscience 130(4): 983-995, 2005.

Reuter, Anne (2002)
Kim AC, Reuter AL, Zubair M, Else T, Serecky K, Bingham NC, Lavery GG, Parker KL, Hammer GD: Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex. Develop 135(15): 2593-2602, 2008.

Bingham NC, Anderson KK, Reuter AL, Stallings NR, Parker KL: Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrin 149(5): 2138-2148, 2008.

Reuter AL, Goji K, Bingham NC, Matsuo M, Parker KL: A novel mutation in the accessory DNA-binding domain of human steroidogenic factor 1 causes XY gonadal dysgenesis without adrenal insufficiency. Europ J Endocrin 157(2): 233-238, 2007.

Schmidt, Daniel (2003)
Lee YK, Schmidt DR, Cummins CL, Choi M, Peng L, Zhang Y, Goodwin B, Hammer RE, Mangelsdorf DJ, Kliewer SA: Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Molec Endocrinol 22(6): 1345-1356, 2008.

Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, Covery DF: Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. J Med Chem 50(24): 6048-6058, 2007.

Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA: International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacol Rev 58(4): 742-759, 2006.

Smith, Christopher (2005)
Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD: Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res 103(12): 1393-1401, 2008.

Tannous, Paul (2001)
Tannous P, Zhu H, Johnstone JL, Shelton JM, Rajasekaran NS, Benjamin IJ, Nguyen L, Gerard RD, Levine B, Rothermel BA, Hill JA: Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci USA 105(28): 9745-9750, 2008.

Tannous P, Zhu H, Nemchenko A, Berry JM, Johnstone JL, Shelton JM, Miller FJ Jr, Rothermel BA, Hill JA: Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation 117(24): 3070-3078, 2008.

Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, LaPlant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ: Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131(2): 391-404, 2007.

Zhu H, Tannous P, Johnstone JL, Kon Y, Shelton JM, Richardson JA, Le V, Levine B, Rothermel BA, Hill JA: Cardiac authophagy is a maladaptive response to hemodynamic stress. J Clin Invest 117(7): 1782-1793, 2007.

Kong Y, Tannous P, Lu G, Berenji K, Rothermel BA, Olson EN, Hill JA: Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation 113(22): 2579-2588, 2006.

Richardson KE, Tannous P, Berenji K, Nolan B, Bayless KH, Davis GE, Rothermel BA, Hill JA: Guanosine triphosphatase activation occurs downstream of calcineurin in cardiac hypertrophy. J Investig Med 53(8): 414-424, 2005.

Rothermel BA, Berenji K, Tannous P, Kutschke W, Dey A, Nolan B, Yoo KD, Demetroulis E, Gimbel M, Cabuay B, Karimi M, Hill JA: Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure. Physiol Genomics 23(1): 18-27, 2005.

Tuckerman, Jason (2003)
Gilles-Gonzalez MA, Gonzalez G, Sousa EH, Tuckerman J: Oxygen-sensing histidine-protein kinases: assays of ligand binding and turnover of response-regulator substrates. Methods in Enzym 437: 173-189, 2008.

Sousa EH, Tuckerman JR, Gonzalez G, Gilles-Gonzalez MA: DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis. Protein Science 16(8): 1708-1719, 2007.

Sousa EH, Tuckerman JR, Gonzalez G, Gilles-Gonzalez MA: A memory of oxygen binding explains the dose response of the heme-based sensor FixL. Biochemistry 46(21): 6249-57, 2007.

Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA: A distal arginine in oxygen-sensing Heme-PAS domains is essential to ligand binding, signal transduction, and structure. Biochem 42(25): 7701-7708, 2003.

Valasek, Mark (2002)
Valasek MA, Clarke SL, Repa JJ: Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. J Lipid Res 48(12): 2725-2735, 2007.

Repa JJ, Li H, Frank-Cannon TC, Valasek MA, Turley SD, Tansey MG, Dietschy JM: Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J Neurosci 27(52): 14470-14480, 2007.

Valasek MA, Repa JJ: The power of real-time PCR. Adv Physiol Educ 29(3); 151-159, 2005.

Valasek MA, Weng J, Shaul PW, Anderson RG, Repa JJ: Caveolin-1 is not required for murine intestinal cholesterol transport. J Biol Chem 280(3): 28103-28109, 2005.

Li H, Repa JJ, Valasek MA, Beltroy EP, Turley SD, German DC, Dietschy JM: Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease. J Neuropathol Exp Neurol 64(4): 323-333, 2005.

Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T. Kedzierski RM, Yanagisawa M: Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci USA 101(4): 1045-1050, 2004.

Wang, Andrew (2004)
Fairhurst AM, Hwang SH, Wang A, Tian XH, Boudreaux C, Zhou XJ, Casco J, Li QZ, Connolly JE, Wakeland EK: Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Europ J Immunol 38(7):1971-1978, 2008.

Fairhurst AM, Mathian A, Connolly JE, Wang A, Gray HF, George TA, Boudreaux CD, Zhou XJ, Li QZ, Koutouzov S, Banchereau J. Wakeland EK: Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice. Europ J Immunol 38(7):1948-1960, 2008.

Subramanian S, Tus K, Li QZ, Wang A, Tian XH, Zhou J, Liang C, Bartov G, McDaniel LD, Zhou XJ, Schultz RA, Wakeland EK: A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci USA 103(26): 9970-9975, 2006.

Wang, Michael (2005)
Infante RE, Radhakrishnan A, Abi-Mosleh L, Kinch LN, Wang ML, Grishin NV, Goldstein JL, Brown MS: Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J Biol Chem 283(2): 1064-1075, 2008.

Suh JM, Zeve D, McKay R, Seo J, Salo Z, Li R, Wang M, Graff JM: Adipose is a conserved dosage-sensitive antiobesity gene. Cell Metab 6(3): 195-207, 2007.

Waung, Maggie (2002)
Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM: Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron 59(1): 84-97, 2008.

Webb, Jadon (2001)
Webb J, Cannon SC: Cold-induced defects of sodium channel gating in atypical periodic paralysis plus myotonia. Neurol 70(10): 755-761, 2008.

Wedin, Kyle (2002)
Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH: Properties of WNK1 and implications for other family members. J Biol Chem 280(29): 26653-26658, 2005.

Young, Bryan (2001)
Chang S, Young BD, Li S, Qi X, Richardson JA, and Olson EN: Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10.  Cell. 2006 July 28;126(2):321-34.

Zeve, Daniel (2004)
Tang W, Zeve D, Suh JM, Bosnakovski D, Kyba M, Hammer RE, Tallquist MD, Graff JM: White fat progenitor cells reside in the adipose vasculature. Science 322(5901): 583-586, 2008.

Suh JM, Zeve D, McKay R, Seo J, Salo Z, Li R, Wang M, Graff JM: Adipose is a conserved dosage-sensitive antiobesity gene. Cell Metab 6(3): 195-207, 2007.

Quick Links