UT Southwestern Medical Center's St. Paul Building, located at 5909 Harry Hines Blvd., operates 300 staffed beds with specialties in Cardiology, Emergency Medicine, Internal Medicine, General Surgery, Obstetrics/Gynecology and Orthopedics. Recognized for premier cardiovascular and pulmonary services, UT Southwestern University Hospital-St. Paul Building is home to the UT Southwestern/St. Paul Heart and Lung Transplant Program.

UT Southwestern physicians provide expert medical and pre- and post-surgical management of patients who are awaiting, or who have undergone, heart and/or lung transplantation. More than 300 heart transplants have been performed since the inception of the program in 1988. Survival rates for the first three years after transplantation are among the best in the country.

The lung component of the transplant program began in 1990. Physicians here have been especially successful in offering transplantation to patients with cystic fibrosis, a genetic disease resulting in progressive lung destruction. The pulmonary division, with its pulmonary function laboratory, has physicians on staff with experience in managing cystic fibrosis, pulmonary hypertension, interstitial fibrosis and pulmonary neuromuscular diseases.