Lead Investigator

Joel Elmquist, D.V.M., Ph.D. has identified new CNS pathways that contribute to the regulation of body weight. He has developed a series of genetically-modified mice that provide key reagents for the dissection of the relative roles of different hypothalamic signaling pathways in feeding and satiety. He was recently recruited from Harvard to direct a Center for Hypothalamic Research to study Obesity at UTSW. He is Chair of Integrative Physiology of Obesity and Diabetes study section.

Associate Investigators

Michael Lutter, M.D., Ph.D.

Bassil M. Kublaoui, M.D., Ph.D. is an Assistant Professor in Pediatrics who was supported by the P20 as a Fellow. Now an independent investigator, he will decipher the mechanism by which single-minded 1 (SIM1) regulates body weight.

Eric Nestler, M.D., Ph.D.

Masashi Yanagisawa M.D., Ph.D. is a member of the U.S. National Academy of Sciences and an Investigator of the Howard Hughes Medical Institute. He discovered both the ligands and the receptors for two key hormonal systems that regulate vascular tone and arousal (endothelins and orexins).   

Jeffrey Zigman, M.D., Ph.D.

Andrew Zinn, M.D., Ph.D. is a human geneticist who discovered that mutations in single-minded 1 (SIM1), a protein expressed in the hypothalamus, causes early onset obesity in humans.