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 Health Watch -- The Heart: Plaque Buildup
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Health Watch is a Public Service of the Office of News and Publications and is intended to provide general information only and should not replace the advice of a medical professional. You should contact your physician if you have questions about any of these topics.


This week on Healthwatch, we've been talking about the heart and related topics. Previously, we talked about a positive benefit of cholesterol in cells. But when cholesterol builds into artery-clogging plaques, it becomes dangerous. Researchers at UT Southwestern Medical Center recently found that the body's immune system plays a role in plaque buildup.

Microphages circulate in the blood stream, helping the body fight off infections and foreign substances, but Dr. Toru Miyazaki, a UT Southwestern immunologist, says they go on to encourage a buildup of fats inside arteries. That buildup narrows arteries, restricting blood flow, and if pieces of plaque break off, it can clog arteries and lead to heart attack or stroke. Researchers found that inhibiting the function that protects microphages can help prevent plaque buildup.

Next: your role in community heart health.

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April 2005

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