|
EDUCATION/TRAINING
| Institution and Location |
Degree
|
Years
|
Field
|
| Wayne State University, Michigan |
Ph.D.
|
1981
|
Cell Biology and Anatomy
|
| Wayne State University, Michigan |
|
1977
|
Reproductive Biology
|
| Kalamazoo College, Michigan |
B.A.
|
1975
|
Reproductive Biology
|
RESEARCH AND PROFESSIONAL EXPERIENCE
| 1983 - 1986 |
|
Research Associate, University of Pennsylvania, School of Veterinary Medicine |
| 1986 - 1989 |
|
Assistant Professor, Department of Cell Biology and Assistant Investigator, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas |
| 1989 |
|
Adjunct Professor, Department of Veterinary Physiology/Pharmacology, Texas A&M University, College of Veterinary Medicine |
| 1990 - 1992 |
|
Assistant Professor, Department of Biochemistry and Senior Associate, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas |
| 1992 - 1998 |
|
Associate Professor, Department of Biochemistry and Senior Associate, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas |
| 1998 - Present |
|
Professor, Department of Biochemistry and Senior Associate, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas |
HONORS
| 1983-1984 |
|
NIH Postdoctoral Fellowship, University of Pennsylvania School of Veterinary Medicine |
| 1989 |
|
USDA Unit Award for Distinguished Service: Application of Gene Transfer to Farm Animals |
| 1992 |
|
Carol-Nachman Prize in Rheumatology, State Capital of Wiesbaden, Germany |
|
|
Scientific Advisory Board of Induced Mutant Resource, Jackson Laboratory, Bar Harbor, ME |
SELECTED PUBLICATIONS
Geppert, M., Khovotecv, M., Krasnoperov, V., Goda, Y., Missler, M., Hammer, R.E., Ichtchenko, K., Petrenko, A.G., and Sudhof, T.C. (1998) Neurexin Ia is a major a-latrotoxin receptor that cooperates in a-latrotoxin action. J. Biol. Chem. 273:1705-1710.
Horton, J.D., Shimomura, I., Brown, M.S., Hammer, R.E., Goldstein, J.L., and Shimano, H. (1998) Activation of cholesterol synthesis in preferance to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J. Clin. Invest. 101:2331-2339.
Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J-M. A., Hammer, R.E., and Mangelsdorf, D.J. (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRa. Cell 93:693-704.
Yanagisawa, H., Hammer, R.E., Richardson, J.A., Williams, S.C., Cloutheir, D.E., and Yanagisawa, M. (1998) Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J. Clin. Invest. 102:22-33.
Zhou, M., Sayad, A., Simmons, W.A., Jones, R.C., Maika, S.D., Satumtira, N., Dorris, M.L., Gaskell, S.J., Bordoli, R.S., Sartor, R.B., Slaughter, C.A., Richardson, J.A., Hammer, R.E., and Taurog, J.D. (1998) Specificity of peptides bound to HLA-B27 influences the prevalence of arthritis in HLA-B27 transgenic rats. J. Exp. Med. 188:877-886.
Onderdonk, A.B., Richardon, J.A., Hammer, R.E., and Taurog, J.D. (1998) Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease. Infection & Immunity 66:6022-6023.
Shimomura, I., Hammer, R.E., Richardson, J.A., Ikemoto, S., Bashmakov, Y., Goldstein, J.L., and Brown, M.S. (1998) Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes & Development 12:3182-3194.
Li, S., George-Raizen, B.J., Hammer, R.E., and Garrard, W.T. (1998) Accurate quantification of expression of transgenes marked with restriction endonuclease site polymorphisms by RT-PCR. Biotechniques 25:558-562.
Tian,H., Hammer, R.E., Matsumoto, A.M., Russell, D.W., and McKnight, S.L. (1998) Evidence of a gene regulatory circuit controlling cardiac output during mammalian embryogenesis. Genes & Development 12:3320-3324.
Korn, B.S., Shimoura, I., Bashmakov, Y., Hammer, R.E., Horton, J.D., Goldstein, J.L., and Brown, M.S. (1998) Blunted feedback suppression of SREPB processing by dietary cholesterol in transgenic mice expression sterol-resistant SCAP (D443N). J. Clin. Invest. 1l02:2050-2060.
Gariepy, C.E., Williams, S.C., Richardson, J.A., Hammer, R.E., and Yanagisawa, M. (1998) Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of hirschsprung disease. J. Clin. Invest. 102:1092-1101.
Hammer, R.E. (1998) Egg culture: the foundation. Int J. Dev. Biol. 42:833-839.
Missler, M., Hammer, R.E., and Sudhof, T.C. (1998) Neurexophilin binding to a-neurexins. J. Biol. Chem. 273:34716-34723.
Devine, J.H., Eubank, D.W., Clouther, D.E., Tontonoz, P., Spiegelman, B.M., Hammer, R.E., and Beale, E.G. (1999) Adipose ezpression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-receptor (gamma) and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo. J. Biol Chem. 274:13604-13612.
Taurog, J.D., Maika, S.D., Satumtira, N., Dorris, M.L., McLean, I.L., Yanagisawa, H., Sayad, A., Stagg, A.J., Fox, G.M., O'Brien, A.L., Rehman, M., Zhou, M., Weiner, A.L., Splawski, J.B., Richardson, J.A., and Hammer, R.E. (1999) Inflammatory disease in HLA-B27 transgenic rats. Immunological Reviews 169:209-223.
Trommsdorff, M., Gotthardt, M., Heisberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R.E., Richardson, J.A., and Herz, J. (1999) Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97:689-701.
Alcorn, J.L., Hammer, R.E., Graves, K.R., Smith, M.E., Maika, S.D., Michael, L.F., Gao, E., Wang, Y., and Mendelson, C.R. (1999) Analysis of genomic regions involved in regulation of the rabbit surfactant protein A gene in transgenic mice. Am. J. Physiol 277 (Lung Cell. Mol. Physiol. 21): L349-L361.
Chemelli, R.M., Willie, J.T., Sinton, C.M., Elmquist, J.K., Scammell, T., Lee, C., Richardosn, J.A., Williams, S.C., Ziong, Y., Kisanuki, Y., Fitch, T.E., Nakazato, M., Hammer, R.E., Saper, C.B., and Yanagisawa, M. (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437-451.
Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S., and Goldstein, J.L. (1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401:73-76.
Hosaka, M., Hammer, R.E., and Sudhof, T.C. (1999) A phospho-switch controls the dynamic association of synapsins with synaptic vesicles. Neuron 24:377-387.
Li, S., Hammer, R.E., George-Raisen, J.B., Meyers, K.C., and Garrard, W.T. (2000) High level rearrangement and transcription of YAC-based mouse IgK transgenics containing distal regions of the contig. J. Immunol., in press.
Fernandez-Chacon, R., Alvarez de Toledo, G., Hammer, R.E., and Sudhof, T.C. (2000) Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice. J. Biol. Chem., in press.
|
|
|
