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Hemostasis - Anticardiolipin Antibodies (IgG, IgM, IgA)
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Test Description
Test Name
Anticardiolipin Antibodies (IgG, IgM, IgA)
Synonym(s)
ACLA, Cardiolipin Antibodies
Description
Antiphospholipid antibodies are associated with recurrent thrombosing both venous and arterial, and recurrent fetal loss. They are very heterogeneous, detected by clotting assays (often called lupus anticoagulants) or immunologic assays. Cardiolipin is a negatively charged phospholipid which is used in an ELISA Assay to detect antibodies in the patient's serum. These antibodies may be IgG, IgM, and/or IgA. When testing for phospholipid antibodies, both the lupus anticoagulants test and cardiolipin antibodies should be ordered since patients can have either or both antibodies. Patients with current or prior syphillis infections may have a positive anticardiolipin antibody test. Transient anticardiolipin antibodies can be seen with infections. Recommend repeat study in 4 - 6 months.
Methodology
ELISA
Performed
Monday, Thursday
Turnaround Time
1-5 days
Specimen Requirements
5 mL serum (red top or SST tube)
Separate from cells as soon as possible and freeze serum immediately.

Transport frozen.

Minimum volume 2 mL.
Rejection Criteria
Serum hemolyzed, icteric, or lipemic.
CPT Code(s)
86147 x 3
Reference Range

IgG ≤13 GPL
IgM ≤ 9 MPL
IgA ≤ 16 APL

Contact Information
Hemostasis Lab: 214-645-5067
Customer Service: 214-645-7057, Toll Free 877-887-8136
Last Modified: March 12, 2008