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| Test Description |
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Test Name
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Chromosome Analysis, Blood, Leukemia Study |
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Synonym(s)
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Cytogenetics, Blood, Leukemia Study
Karyotype, Blood, Leukemia Study
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Description
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Cytogenetic analysis of unstimulated peripheral blood leukocytes to assess for the presence of a neoplastic clone. |
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Methodology
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Cells are harvested from two or more unstimulated cultures. Twenty metaphase spreads are fully analyzed and two karyotypes are prepared. If abnormalities are found, at least two karyotypes are prepared for each abnormal clone. |
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Performed
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Daily. |
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Turnaround Time
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1 - 3 weeks. Preliminary results can be provided sooner if necessary. |
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Specimen Requirements
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5 - 10 ml aseptically collected blood in a green top sodium heparin tube. Oncologic diagnosis (suspected or confirmed) must be provided.
Note:
- Bone marrow aspirate is always the preferred specimen for cytogenetic analysis in cases of suspected leukemia. Blood may be substituted in cases of untreated chronic myeloid leukemia (CML) or in acute leukemias with WBCs >35,000, but the rate of abnormal clone detection is always better in bone marrow.
- Deliver to lab at room temperature within 24 hours. If collected over a weekend, call the laboratory to make arrangements for specimen delivery. May be refrigerated if not transported immediately. Do not freeze. Protect from heat or cold.
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Rejection Criteria
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Frozen, clotted, hemolyzed or grossly contaminated specimens. Incorrect anticoagulant used. |
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CPT Code(s)
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88237, 88262, 88291
More than 20 cells counted: add 88285
More than 2 karyotypes: add 88280
Fewer than 15 cells counted: 88237, 88261, 88280, 88285, 88291
No cells available for analysis, or study cancelled after initiation of culture: 88237
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Reference Range
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See interpretive report. |
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Contact
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Cytogenetics Lab: (214) 645-7000
Customer Service: (214) 645-7057 or Toll Free (877) 887-8136 |
Last Modified: May 2, 2007 |
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