Biosketch Top
Dr. Terman completed his Bachelor of Science degree in Biology at Wheaton College in Wheaton, Illinois in 1991. After working for a year in Marine Science, he began his graduate work at The Ohio State University and received his Ph.D. in Neuroscience in 1997. As a graduate student in George F. Martin's laboratory he utilized the unique embryology of the marsupial opossum and focused on understanding the potential for axon regeneration in the spinal cord of mammals and the factors associated with its failure. As an initial step towards identifying the molecular mechanisms limiting axon regeneration, he focused his postdoctoral training on investigating the molecular mechanisms that enable axonal growth and guidance.
While a postdoctoral fellow with Alex L. Kolodkin at the Johns Hopkins University School of Medicine, Dr. Terman utilized molecular and genetic approaches in both Drosophila and mammals to better characterize the molecular mechanisms underlying axon guidance. He joined the faculty of the Center for Basic Neuroscience in 2005.
Research Top
A normal functioning human nervous system requires the interconnection of billions of neurons but much remains to be learned on how these circuits are assembled, and how they may be repaired after injury or disease. Remarkably, the signals that help neurons find and connect with their targets appear common to all animals. Simple animals like worms and flies use many of the same axon guidance signals as more complex animals. These extracellular axon guidance signals or cues guide axons by associating with cell surface receptors present on growing axons. How these axon guidance cues alter the cytoskeletal machinery necessary to steer an axon is still poorly understood, however. Relatively little is known of the intracellular signaling molecules and mechanisms within a growth cone that orchestrate axon growth, navigation, and target selection.
Research in my laboratory focuses on better understanding the molecules and mechanisms that assemble axonal connections with a goal of utilizing this knowledge to encourage axons to reestablish their connections after trauma or disease. To address these questions, we employ a combination of molecular biological, biochemical, genetic, and cell biological approaches both in vivo and in vitro in simple and complex organisms. Work currently underway in the lab is focused on 1) identifying the molecules involved in neural connectivity and assembling them into signaling pathways, 2) studying the functional importance of these proteins in the formation of the nervous system, 3) characterizing the biochemical and physiological role of these proteins, and 4) using these findings to devise and test therapeutic strategies to encourage axons to regrow after injury. One of our major interests is to better characterize a new family of proteins, the MICALs, that contain a flavoprotein oxidoreductase domain that is required for proper neuronal connectivity (See Figure). Our results suggest that MICALs are oxidoreductase enzymes and support a novel role for oxidation-reduction (redox) signaling mechanisms in axonal steering and targeting.
Recent Publications Top
Gupta, N. and J. R. Terman. (2008) Characterization of MICAL Flavoprotein Oxireductases: Expression and Solubility of Different Truncated Forms of MICAL. Proceedings of the 16th International Symposium on Flavins and Flavoproteins. 345-350.
Yazdani, U., Z. Huang, and J.R. Terman. (2008) The Glucose Transporter (GLUT4) Enhancer Factor is required for normal wing-positioning in Drosophila, Genetics, 178: 919-929.
Huang, Z., U. Yazdani, K. L. Thompson-Peer, A. L. Kolodkin, and J.R. Terman. (2007) Crk-associated substrate (Cas) adaptor protein functions with integrins to specify axon guidance during development, Development, 134: 2337-2347.
Yazdani, U., and Terman, J. R. (2006) The semaphorins. Genome Biology 7: 211-225.
Ayoob, J. C., Terman, J. R. and Kolodkin, A. L. (2006) Drosophila Plexin B is a semaphorin-2a receptor required for axon guidance. Development 133: 2125-2135.
Pasterkamp, R.J., H. Dai, J.R. Terman, K. Wahlin, B. Kim, B.S. Bregman, P.G. Popovich, and A.L. Kolodkin, (2006) MICAL flavoprotein monooxygenases: expression in the developing and adult rat nervous system and following spinal cord injuries, Mol Cell Neurosci, 31: 52-69.
Siebold, C., Berrow, N., Walter, T. S., Harlos, K., Owens, R. J., Stuart, D. I., Terman, J. R., Kolodkin, A. L., Pasterkamp, R. J., and Yvonne Jones, E. (2005) High resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule. Proc. Nat. Acad. Sci. USA 102;16,836-16,841.
Terman, J.R., and A.L. Kolodkin, (2005) Response to Comment on ''Nervy Links Protein Kinase A to Plexin- Mediated Semaphorin Repulsion'', Science, 309(2005)558.
Ayoob, J.C., H.-H. Yu, J.R. Terman, A.L. Kolodkin (2004) DrGC-1, a Drosophila
receptor guanylyl cyclase, is a key component of semaphorin-1a mediated axon guidance, J. Neurosci., 24:6639-6649.
Terman, J.R., and A.L. Kolodkin (2004) The AKAP nervy links Protein Kinase A to
plexin-mediated semaphorin repulsion, Science, 303:1204-1207.
Terman, J.R., T. Mao, R.J. Pasterkamp, H.-H. Yu, and A.L. Kolodkin (2002) MICALs, a
family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion, Cell, 109:887-900.
Martin, G.F., J.R. Terman, and X.M. Wang (2000) Regeneration of descending spinal
axons after transection of the thoracic spinal cord during early development in the North
American opossum, Didelphis virginiana, Brain Res. Bulletin, 53:677-687.
Terman, J.R., X.M. Wang, and G.F., Martin (2000) Repair of the transected spinal cord at
different stages of development in the North American opossum, Didelphis virginiana,
Brain Res. Bulletin, 53:845-855.
Wang, X.M., J.R. Terman, and G.F. Martin (1999) Rescue of axotomized rubrospinal
neurons by brain-derived neurotrophic factor (BDNF) in the developing opossum,
Didelphis virginiana, Devl. Brain Res., 118:177-184.
Terman, J.R., and A.L. Kolodkin (1999) Attracted or repelled? Look within. Neuron,
23:193-195.
Terman, J.R., X.M. Wang, and G.F. Martin (1999) Developmental plasticity of ascending spinal axons. Studies using the North American opossum, Didelphis virginiana, Devl. Brain Res., 112:65-77.
Lab Members Top
Zhiyu Huang, M.S. zhuang@mednet.swmed.edu
Umar Yazdani, M.D. umar.yazdani@utsouthwestern.edu
Postdoctoral Fellows
Nidhi Gupta, PhD. Nidhi Gupta@utsouthwestern.edu
Students
Ruei-Jiun Hung, MS. Ruei-JiunHung@utsouthwestern.edu
Taehong Yang taehongyang@utsouthwestern.edu
Jimok Yoon, MS jimok.yoon@utsouthwestern.edu
