CMC Critical Care ServicesRESEA

CURRENT RCH STUDIES:

An Investigation of the Efficacy and safety of Drotrecogin Alfa (activated) in Pediatric Severe Sepsis  

- PI: Marita Thompson, M.D.
- RC: Deb Town, RN
- Backup RC: Tracine Adame, RN
- Start Date: November 2002
- Projected End Date: November 2004

Extracorporeal Life Support Organization (ELSO) Patient  Registry

- PI: John Darling, RRT
- RC:  Deb Town, RN
- Faculty Sponsor:  Marita Thompson, M.D.
- Duration of study: Ongoing

Evidence based ICU design: A proposal for the study of nature in the PICU

- PI: Cindy Darnell, M.D.
- RC: ?
- Faculty Sponsor:  Daniel Stromberg, M.D.
- Start Date: April 2001
- Projected End Date:  April 2005

Measuring Parent Satisfaction with Nurse Practitioners' Care in a Pediatric Intensive Care Unit

- PI:  Dorothy Foglia, RN, MS
- RC: Deb Town, RN
- Faculty Sponsor: Marita Thompson, M.D.
- Start Date: May 2003
- Projected End Date: May 2004

NACHRI VPICU Performance System

- PI: Erica Kirsch, M.D.
- RC:  Deb Town, RN
- Sample size: 2,000/ annually
- Duration of study: Ongoing

Polymorphism of Apolipoprotein E and Outcomes from Traumatic Brain Injury

- PI: Steven Kernie, M.D.
- RC: Deb Town, RN
- Backup RC: Tracine Adame, RN
- Start Date: November 2001
- Projected End Date: January 2005

Prone Positioning in Pediatric Acute Lung Injury

- PI: Shirley Molitor-Kirsch, PCCNP
- Faculty Sponsor: Peter Luckett, M.D.
- RC: Deb Town, RN
- RA:  Kristin Foglia, BS
- Start Date:  May 2002
- Projected End Date:  January 2005

Prospective study of an Enteral Methadone Taper to Prevent Opioid Withdrawal in Fentanyl -tolerant Pediatric Patients

- PI: Jennifer Thompson, M.D.
- Faculty Sponsor: Paul Sheeran, M.D.
- RC:  Kristin Foglia, BS
- Start Date: November 2002
- Projected End Date: June 2004

rBPI21 (Neuprex) in Children Undergoing Cardiopulmonary Bypass
  
- PI: Erica Kirsch, M.D.
- RC:  Deb Town, RN
- Back-up RC: Tracine Adame, RN
- Start Date: July 2003
- Projected End Date: July 2007

Serum S100  and Neuron Specific Enolase in Near-Drowning Patients

- PI: Marita Thompson, M.D
- Start Date:  September 2000
- RC:  Jocelyn Chapman, BS
- Projected End Date:  September 2005 

The Effect of Inflammatory Processes Upon Clinical Outcomes in Post-operative Fontan Patients
 
- PI: David Cooper, M.D.
- Faculty Sponsor: Daniel Stromberg, M.D.
- RC: Jocelyn Chapman, BS
- Backup RC: Tracine Adame, RN
- Start Date: July 2003
- End Date:  July 2005

The Impact of Concomitant Ultra-Low Dose Infusion Naloxone and Therapeutic Infusion Opioid on Opioid Requirements in Pediatrics ICU Patients

- PI: Cindy Darnell, M.D.
- Faculty Sponsor: Paul Sheeran, M.D.
- RC:  Kristin Foglia, BS
- Start Date: January 2003
- Projected End Date: January 2005

A Randomized Multi-center, Double-Blind, Placebo-Controlled, Dose-Ranging, Parallel Group Study of Intravenous Sildenafil in the Treatment of Children, Aged 0-17 with Pulmonary Hypertension After Corrective Cardiac Surgery

- PI: Erica Molitor-Kirsch, M.D.
- RC: Tracine Adame, RN
- Backup RC:  Deb Town, RN
- Start Date: September 2003
- Projected End Date: January 2005

Sedative use around extubation and its influence on extubation failure

- PI:  Peter Luckett, M.D.
- RC: Tracine Adame, RN
- RA: Shirley Montanye, RN
- Start Date: October 2003
- Projected End Date: January 2005

Characteristics of infants and children with ARDS, pneumonia, bronchiolitis and sepsis

- PI:  Peter Luckett, M.D.
- RC:  Tracine Adame, RN
- RA:  Shirley Montanye, RN
- Start Date: October 2003
- Projected End Date: January 2005

Matrix Metalloproteinases in Children Undergoing Cardiopulmonary Bypass

- PI: Erica Molitor-Kirsch, M.D.
- RC:  Tracine Adame, RN
- Start Date: April 2004
- Projected End Date: January 2006

The Role of Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Their Regulators in Pediatric Patients with Acute Inflammatory Cardiomyopathy

- PI: Tia Tortoriello, M.D.
- RC: Tracine Adame, RN
- Start Date: April 2004
- Projected End Date: January 2006

Pediatric IAC-CPR: A Randomized, Clinical Trial

- PI: Daniel Stromberg, M.D.
- RC: Tracine Adame, RN
- Backup RC:  Deb Town, RN
- Projected Start Date: April 2004
- Projected End Date: March 2007

New Upcoming PROJECTS:

RN Retention Study

- PI:  Dorothy Foglia, RN, MS
- Faculty Sponsor: Jim Thomas, MD
- RC:  Kristin Foglia, BS
- Projected Start Date: April 2004
- Projected End Date: April 2005

Enteral Versus Parenteral Nutrition in Hospitalized Children With Acute Pancreatitis

- PI: Lisa Thompson, RN, MS
- Faculty Sponsor: Todd Maxon, MD
- RC:  Kristin Foglia, BS
- Projected Start Date:  May 2004
- Projected End Date:   May 2005

Family Participation in the Process of Brain Death Determination Enhances Consent for Solid Organ Donation  (?on hold?)

- PI: Tania Burns, M.D.
- RC:  Deb Town, RN
- Projected Start Date: June 2004
- Projected End Date:  June 2007

Metabolic Chemical Monitoring Through Sprectral Chemometry with MEMS

- PI:  Tania Burns, M.D.
- RC:  Deb Town, RN
- Projected Start Date: January 2005
- Projected End Date:

Other future studies in design phase-

-Stem Cell and Postoperative Congenital Heart Patients- Stromberg
- Nesiritide Study- Tia Tortoriello, M.D.
-Safety Study- Marita Thompson, M.D.
-Reengineering PICU Research- Peter Luckett, MD

OTHER COLLABORATING DEPARTMENTS AND PICU RESEARCH:

A Multi-Center Group Study of Acute Liver Failure Study

- Collaborating department:  Gastroenterology
- PI: Norberto Rodriguez-Baez, M.D.
- RC: Nancy Simonds, RN
- PICU POINT PERSON: Deb Town, RN
- Start Date: 2000
- Projected End Date: ongoing

Sublingual CO2  Study

- PI:  Thomas Abramo, M.D.
- RC:  Simon Ng, RN
- PICU POINT PERSON: none
- Start Date: 2003
- Projected End Date: ?