Research Interests:

• Cellular regulation of metabolism in normal cells and in cancer
  
• Diagnosis and treatment of pediatric metabolic diseases

Recent Publications:

1. DeBerardinis RJ, Coughlin C and Kaplan P. Penicillamine therapy in pediatric cystinuria: experience from a cohort of American children. In press, J Urol (2008).
2. DeBerardinis RJ, Sayed N, Ditsworth D and Thompson CB. Brick by brick: metabolism and tumor cell growth. In press, Curr Opin Genet Dev (2008).
3. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming that fuels growth and proliferation. Cell Metab 7:11-20 (2008).
4. DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S and Thompson CB. Beyond Warburg: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. PNAS USA 104:19345-19350 (2007).
5. Buzzai M, Jones RG, Amaravadi R, Lum JJ, DeBerardinis RJ and Thompson CB. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth in vivo. Cancer Research 67:6745-6752 (2007).
6. Lum JJ, Bui T, Covello KL, DeBerardinis RJ, Simon MC and Thompson CB. The transcription factor HIF-1 plays a critical role in growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 21:1037-1049 (2007).
7. DeBerardinis RJ, Lum JJ and Thompson CB. P13K - dependent modulation of CPT1A expression plays a critical role in regulating lipid metabolism during cell growth.  J. Biol. Chem 281:37372-37380 (2006).
8. DeBerardinis RJ, Medne L and Zackai EH.  DiGeorge syndrome in a patient with isochromosome 18p to a diabetic mother. Am J MedGenet 138, 155 - 159 (2005).
9. DeBerardinis RJ, Lum JJ and Thompson CB. Metazoan autophagy:  cell survival in the land of plenty.  Nat Rev Cell Mol Biol 6, 439 - 448 (2005).
10. Buzzai M, Bauer DE, Jones RG, DeBerardinis RJ, Hatzivassiliou G, Elstrom RL, and Thompson CB.  The glucose dependence on Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation.  Oncogene 24:4165-4173 (2005).

For additional publications: Search PubMed

Education:

• St. Joseph’s University, B.S. Biology, 1992
• University of Pennsylvania, Ph.D., Cell and Molecular Biology, 1998
• University of Pennsylvania, M.D., 2000
• The Children’s Hospital of Philadelphia, Pediatrics and Medical Genetics Residency, 2005

Professional Positions:

• 2008-present: Assistant Professor of Pediatrics and Genetics, University of Texas – Southwestern Medical Center at Dallas, Department of Pediatrics and McDermott Center for Human Growth and Development.