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Xiao-Song Xie, Ph. D.
Professor of Internal Medicine
Graduate Program: Biological Chemistry
Phone: 214-648-7700
Fax: 214-648-7720
Mailing Address:
5323 Harry Hines Blvd, Dallas, TX 75930-8591
E-mail: Xiao-song.Xie@UTSouthwestern.edu
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Research Interests:
- Structure and function of V-type Proton translocating ATPase
- Biochemistry of ABC transporters--ABCG5 and ABCG8.
Lab Personnel
Recent Publications:
- Xie, X.-S., Padron, D., Liao, X., Wang, J., Roth, M.G., De Brabander, J.K., "Salicylihalamide A inhibits the Vo sector of the V-ATPase through a mechanism distinct from Bafilomycin A1" Journal of Biological Chemistry, 279:19755-19763, May 2004.
- Nieland, T., Feng, Y., Brown, J.X., Chuang, T.D., Buckett, P.D., Wang, J., Xie, X.-S., McGraw, T.E., Kirchhausen, T., Wessling-Resnick, M., "Chemical genetic screening idnetifies sulfonamides that raise organellar pH and interfere with endocytic and exocytic membrane traffic" Traffic, 5:478-492, July 2004.
- Crider, B. and Xie, X.-S. (2003) Characterization of the Functional Coupling of Bovine Brain V-ATPase: Effect of Divalent Cations, Phospholipids, and Subunit H (SFD). J. Biol. Chem. 278:44281-44288.
- Wu Y, Liao X, Wang R, Xie X-S, DeBrabender JK, "Total synthesis and initial structure-function analysis of the potent V-ATPase Inhibitors Salicylihalamide A and related Compounds." J Am Chem Society, 124:3245-3253, 2002.
- Ding, J., Wu, Z., Crider, B.P., Ma, Y., Li, X., Slaughter, C., Gong, L., and Xie, X.-S. (2000) Identification and Functional Expression of Four Isoforms of ATPase II, the putative Amminophospholipid Translocase: Effect of Isoform Variations on the ATPase Activity and Phospholipid Selectivity. J. Biol. Chem. 275:23378-23386.
For additional publications: Search PubMed
Education:
- Beijing University, Beijing, China, B.S., 1975, Biochemistry
- Cornell University, Ithaca, NY, Ph.D., 1985, Biochemistry
Professional Positions:
- 2001-present - Professor of Internal Medicine, McDermott Center for Human Growth and Development, UT Southwestern Medical Center
- 1998-2001 - Professor of Internal MedicineDivision of Molecular Transport, UT Southwestern Medical Center
- 1990-1998 - Associate Professor of Internal Medicine Division of Molecular Transport, UT Southwestern Medical Center
- 1987-present - Member of Graduate faculty, Graduate program of Biological Chemistry, Southwestern Graduate School of Biomedical Sciences
- 1987-1990 - Assistant Professor of PhysiologyDepartment of Physiology, UT Southwestern Medical Center
- 1985-1987 - Research Assistant Professor, Dept. Internal Medicine, UT Southwestern Medical Center, Dallas
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