• Polymorphism discovery and characterization
• Genetic determinants of cardiovascular disease
• MicroRNA roles in lung cancer pathogenesis

Lab Personnel

For more information: Computational Biology

1. McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A., Roberts, R., Cox, D.R., Hinds, D.A., Pennacchio, L.A., Tybjaerg-Hansen, A., Folsom, A.R., Boerwinkle, E., Hobbs, H.H. & Cohen, J.C. A Common Allele on Chromosome 9 Associated with Coronary Heart Disease. Science (2007)
2. Kotowski, I.K., Pertsemlidis, A., Luke, A., Cooper, R.S., Vega, G.L., Cohen, J.C. & Hobbs, H.H. A Spectrum of PCSK9 Alleles Contributes to Plasma Levels of Low-Density Lipoprotein Cholesterol. Am J Hum Genet 78, 410-22 (2006).
3. Cohen, J.C., Pertsemlidis, A., Fahmi, S., Esmail, S., Vega, G.L., Grundy, S.M. & Hobbs, H.H. Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. Proc Natl Acad Sci U S A 103, 1810-1815 (2006)
4. Pertsemlidis, A., Zelinka, J., Fondon, J.W., 3rd., Henderson, R.K.H. & Otwinowski, Z. Bayesian statistical studies of the Ramachandran distribution. Statistical Applications in Genetics and Molecular Biology 4, 1-16 (2005)
5. Lancman, J.J., Caruccio, N.C., Harfe, B.D., Pasquinelli, A.E., Schageman, J.J., Pertsemlidis, A. & Fallon, J.F. Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn 234, 948-60 (2005)
6. Ferguson, D.A., Muenster, M.R., Zang, Q., Spencer, J.A., Schageman, J.J., Lian, Y., Garner, H.R., Gaynor, R.B., Huff, J.W., Pertsemlidis, A., Ashfaq, R., Schorge, J., Becerra, C., Williams, N.S. & Graff, J.M. Selective identification of secreted and transmembrane breast cancer markers using Escherichia coli ampicillin secretion trap. Cancer Res 65, 8209-17 (2005)
7. Cohen, J., Pertsemlidis, A., Kotowski, I.K., Graham, R., Garcia, C.K. & Hobbs, H.H. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 37, 161-5 (2005)
8. Wandstrat, A.E., Nguyen, C., Limaye, N., Chan, A.Y., Subramanian, S., Tian, X.H., Yim, Y.S., Pertsemlidis, A., Garner, H.R., Jr., Morel, L. & Wakeland, E.K. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity 21, 769-80 (2004).

For additional publications Search PubMed

Education:

• Princeton University, A.B., 1987, Medieval History and Europe through the Renaissance
• The University of Michigan, M.S., 1988, Cellular and Molecular Biology
• The University of California at Berkeley, Ph.D., 1995, Biophysics

• 2001 - Present - Assistant Professor, The University of Texas Southwestern Medical Center at Dallas, Department of Internal Medicine
• 1999 - 2000 - Postdoctoral Researcher, The University of Texas Southwestern Medical Center at Dallas, McDermott Center for Human Growth and Development
• 1996 - 1999 - Postdoctoral Researcher, The University of Texas Southwestern Medical Center at Dallas, Department of Biochemistry.          
• 1995 - 1996 - Lecturer, The University of California at Berkeley, Department of Physics.