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Helen H. Hobbs, M.D.
Howard Hughes Investigator
Director, McDermott Center
Chief, Division of Clinical Genetics, Internal Medicine
Professor of Internal Medicine and Molecular Genetics
Graduate Program:
Genetics and Development
Phone: 214-648-6724
Mailing Address:
5323 Harry Hines Blvd., Dallas, TX 75390-8591
E-mail: Helen.Hobbs@UTSouthwestern.edu
Fax: 214-648-7539
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Research Interests:
- Genetic determinants of plasma lipid levels
- LDL metabolism
- Role of ABC transporters in lipid transport
Lab Personnel
Recent Publications:
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Romeo S., Pennacchio L.A., Fu Y., Boerwinkle E., Tybjaerg-Hansen A., Hobbs H.H., Cohen, JC (2007) Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL in Caucasians. Nat. Genet. 39:513-516.
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McPherson R., Pertsemlidis A., Kavaslar N., Stewart A., Robert R., Cox D.R., Hinds D.A., Pennacchio L.A., Tybjaerg-Hansen A., Folsom A.R., Boerwinkle E., Hobbs H.H., Cohen J.C. (2007) A common allele on chromosome 9 associated with coronary heart disease. Science 316:1488-1491.
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Cohen J.C., Boerwinkle E., Mosley T.H., Hobbs H.H. (2006) Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354:1264-1272.
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Cohen J.C., Kiss R.S., Pertsemlidis A., Marcel Y.L., McPherson R., Hobbs H.H. (2004) Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science 305:869-872.
For additional publications: Search PubMed
Education:
- Stanford University, Palo Alto, CA, B.A., Human Biology, 1974
- Case Western Reserve University School of Medicine, Cleveland , OH , M.D., Medicine, 1979
- UT Southwestern Medical Center , Dallas, TX, Postdoctoral Fellow, Endocrinology and Molecular Genetics, 1987
Professional Positions:
- 2002 - Present - Howard Hughes Investigator
- 2000 - Present - Director, McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas
- 1995 - Present - Professor--Internal Medicine and Molecular Genetics, Chief of Division of Medical Genetics, University of Texas Southwestern Medical Center at Dallas
- 1991 - 1994 - Associate Professor
- 1987 - 1990 - Assistant Professor
- 1983 - 1987 - Postdoctoral Fellow and Endocrinology Fellow—Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas
- 1982 - 1983 - Chief Resident, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas
- 1980 - 1982 - Resident, Internal Medicine, Parkland Memorial Hospital, Dallas
- 1979 - 1980 - Intern, Internal Medicine, Columbia-Presbyterian Hospital, New York
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