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Helen H. Hobbs, M.D.
Howard Hughes Investigator
Director, McDermott Center
Chief, Division of Clinical Genetics, Internal Medicine
Professor of Internal Medicine and Molecular Genetics
Graduate Program:
Genetics and Development
Phone: 214-648-6724
Mailing Address:
5323 Harry Hines Blvd., Dallas, TX 75390-8591
E-mail: Helen.Hobbs@UTSouthwestern.edu
Fax: 214-648-7539
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Research Interests:
- Genetic determinants of plasma lipid levels
- LDL metabolism
- Role of ABC transporters in lipid transport
Lab Personnel
Recent Publications:
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Romeo S., Yin W., Kozlitina J., Pennacchio L.A., Boerwinkle E., Hobbs H.H., Cohen J.C. (2009) Genetic variations in ANGPTL family members implicate nonredundant roles in triglyceride metabolism in humans. J. Clin. Invest. 119: 70-79.
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Romeo S., Kozlitina J., Xing C., Pertsemlidis, A., Cox, D., Pennacchio L.A., Boerwinkle, E., Cohen JC, Hobbs, H.H. (2008). Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40:1460-1465.
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Zhang D-W, Garuti R., Tang W-J, Cohen J.C., Hobbs H.H. (2008) Structural Requirements for PCSK9-mediated degradation of the low density lipoprotein receptor. Proc. Natl. Acad. Sci. USA. 105: 13045-13050.
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McPherson R., Pertsemlidis A., Kavaslar N., Stewart A., Roberts R., Cox D.R., Hinds D.A., Pennacchio L.A., Tybjaerg-Hansen A., Folsom A.R., Boerwinkle E., Hobbs H.H., Cohen JC (2007) A common allele on chromosome 9 associated with coronary heart disease. Science 316:1488-1491.
- Romeo S., Pennacchio L.A., Fu Y., Boerwinkle E., Tybjaerg-Hansen A., Hobbs H.H., Cohen, JC (2007) Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL in Caucasians. Nat. Genet. 39:513-516.
For additional publications: Search PubMed
Education:
- Stanford University, Palo Alto, CA, B.A., Human Biology, 1974
- Case Western Reserve University School of Medicine, Cleveland , OH , M.D., Medicine, 1979
- UT Southwestern Medical Center , Dallas, TX, Postdoctoral Fellow, Endocrinology and Molecular Genetics, 1987
Professional Positions:
- 2002 - Present - Howard Hughes Investigator
- 2000 - Present - Director, McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas
- 1995 - Present - Professor--Internal Medicine and Molecular Genetics, Chief of Division of Medical Genetics, University of Texas Southwestern Medical Center at Dallas
- 1991 - 1994 - Associate Professor
- 1987 - 1990 - Assistant Professor
- 1983 - 1987 - Postdoctoral Fellow and Endocrinology Fellow—Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas
- 1982 - 1983 - Chief Resident, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas
- 1980 - 1982 - Resident, Internal Medicine, Parkland Memorial Hospital, Dallas
- 1979 - 1980 - Intern, Internal Medicine, Columbia-Presbyterian Hospital, New York
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