Benign Prostatic Hyperplasia (BPH) is a urologic disorder of aging men. In the United States, more than 55 percent of men over the age of 60 are affected. Aside from aging and the male sex hormone (androgenic) stimulation, the causes of BPH, especially at the cellular and molecular level, remain unclear. BPH is primarily a disease of stromal proliferation of which smooth muscle (SM) is a major component. Little is known regarding the regulation of prostate smooth muscle proliferation during the initiation and progression of BPH.
The long-term research goal is to investigate smooth muscle phenotypic modulation during the natural history of BPH and its related disorders. This line of research should allow insight into the molecular mechanisms underlying BPH and contribute to the development of future therapeutic approaches.
There are two 360-square-foot laboratories in the urology department dedicated to BPH research. In addition, researchers have the access to UT Southwestern Medical Center's urological tissue depository, urology histology core, and other departmental core facilities.
PSA (Prostate Specific Antigen)
Expression in Human Prostate
in situ Hybridization Analysis
In situ hybridization analysis
performed to localize PSA mRNA
expression in human prostate.
In situ hybridization analysis
performed to localize PSA mRNA
expression in human prostate.
Principal Investigators:
Research Interests
Publications
For more information about the Department of Urology, contact:
Phone: 214-648-4765, FAX: 214-648-4789
Mailing Address: 5323 Harry Hines Blvd., J8.148, Dallas, TX 75390-9110
