|
The Division of Pediatric Infectious Disease has a long tradition of training fellows in the subspecialty. Since 1965 86 fellows have completed training in infectious diseases, 80% whom are involved in teaching and research in university-affiliated medical centers.
The purposes of the training program are to provide a background in laboratory techniques of classical microbiology, immunology and molecular biology, to provide experience in application of the scientific method to clinical and laboratory research, and to develop competence in diagnosis and management of infectious diseases. Clinical training is in the form of consultations, rounds and conferences, and outpatient Infectious Diseases and HIV Clinics.
The Division of Pediatric Infectious Disease is comprised of seven (7) active faculty members, each of whom has specific research and clinical interests:
-
George H. McCracken, Jr., M.D. (animal models of infections, clinical trials)
-
Octavio Ramilo, M.D. (immunogenetic profile of children with infections, clinical trials, HIV)
-
Pablo Sanchez, M.D. (congenital syphilis and neonatal infections)
-
Jane D. Siegel, M.D. (pediatric infection control, neonatal bacterial infections)
- Doug Hardy, M.D. (Mycoplasma infections, HIV infections)
-
Michelle Gill, MD, PhD. (ontogeny of immune responses to RSV infection)
-
Theresa Barton, M.D.(vaccine studies, HIV/AIDS)
Each trainee is instructed in all relevant basic laboratory methods, including fundamentals of aerobic and anaerobic bacteriology, antibiotic susceptibility testing, antibiotic assays, serologic techniques, immunoelectrophoresis, the fluorescent antibody method, tissue culture technique and leukocyte function studies. Additionally, the fellows have ample opportunity to work with collaborators in molecular microbiology to acquire basic techniques such as PCR, microarray analyses, cloning, purification of bacterial outer membrane components (eg. endotoxin), etc. The trainee carries through one or more research protocols of his/her own design with supervision by the program directors and collaborators. This is tailored to the interests and capabilities of the individual trainee either in basic laboratory experimentation or in clinical research.
The clinical material available at Children’s Medical Center and on the neonatal service at Parkland Memorial Hospital is extensive. There are approximately 120,000 outpatient visits, 9,000 pediatric admissions and 16,000 deliveries per year. A high proportion of these have infectious disease problems; therefore, trainees have the opportunity to see many common infections and most of the rarer disorders. Infectious disease clinical rounds are conducted daily and the clinic is scheduled twice weekly. We average approximately 60 inpatient consultations monthly and 15-20 new outpatient consultations monthly.
The three-year program aims to provide individuals with sufficient background to pursue a career of independent research, teaching and managing patients with wide variety of pediatric infectious diseases.
Prerequisites include one year of internship and two years of pediatric residency. Applicants must:
- Be citizens of the United States or Canada OR
- Hold a permanent resident visa OR
- Have passed the USLME examination and be eligible for an ECFMG-sponsored visa. In addition foreign medical graduates will be required to provide original documentation of education and licensure upon acceptance into the program.
Click Here for Fellowship Application. Print and complete the application in its entirety, then forward it and all relevant material to our office by e-mail, fax or regular mail.
Applications should be returned to: George McCracken, M.D.
Professor of Pediatrics
5323 Harry Hines Blvd., F3. 202
Dallas, TX 75390-9063
Phone: (214) 648-3439
Fax: (214) 648-2961
E-mail: george.mccracken@utsouthwestern.edu
Current Fellows (As of July 1, 2007)
Monica Ardura, M.D. (4th Year)
Cynthia Somers, M.D. (3rd Year)
Roberto Santos, M.D. (3rd Year)
Steven M. Grube, M.D. (2nd Year)
Chonnamet Techasaensiri, M.D. (2nd Year)
Michael Chang, M.D. (1st year)
Carla Garcia, M.D. (1st year)
Since 1996, five (5) fellows have received two-year fellowship awards from the Pediatric Infectious Diseases Society and one received a MedImmune Fellowship Award for Viral Respiratory Infections. Two trainees recently received NIH K08 awards within one year of completing fellowship training. In each of the last four years, two fellows have received fellowship travel grants to present their research at the annual international Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) sponsored by the American Society of Microbiology. Our fellows average eight (8) presentations yearly at international infectious disease and pediatric meetings. In 2004, our fellows had fifteen (15) presentations accepted.
Selected Recent Publications by Fellows (1999-2004):
- Michelow IC, Wendel GD, Jr., Norgard MV, Zeray F, Leos NK, Alsaadi R, Sánchez PJ: Central nervous system infection in congenital syphilis. N Engl J Med 2002;346:1792-1798.
- Velaphi S, Siegel JD, Wendel GD, Jr., Cushion N, Eid WM, Sánchez PJ: Early-onset group B streptococcal infection following a combined maternal and neonatal group B streptococcal chemoprophylaxis strategy. Pediatrics 2003;111:541-547.
- Hardy RD, Jafri HS, Olsen K, Hatfield J, Iglehart J, Rogers BB, Patel P, Cassell G, Ramilo O, McCracken GH. Mycoplasma pneumoniae Induces Chronic Respiratory Infection, Airway Hyperreactivity, and Pulmonary inflammation: A Murine Model of Infection – Associated Chronic Reactive Airway Disease. Infection and Immunity 2002;70:649-654.
- Hardy RD, Rios AM, Chavez-Bueno S, Jafri HS, Hatfield J, Rogers BB, Ramilo O, McCracken GH. Antimicrobial and Immunologic Activity of Clarithromycin in a Murine Model of Mycoplasma pneumoniae Pneumonia. Antimicrobial Agents and Chemotherapy 2003;47(5):1614-1620.
- Lee MC, Rios AM, Fonseca-Aten M, Mejias A, Cavuoti, McCracken GH, Hardy RD. Management and Outcome of Children with Skin and Soft Tissue Abscesses caused by Community-Acquired MRSA. Pedi infect Dis J 2004; 23(2):123-127.
- Jafri HS, Chávez-Bueno S*, Mejías A, Ríos AM, Nassi S, Yusuf M, Kapur P, Gómez AM, Hardy RD, Hatfield J, Rogers BB, Krisher K and Ramilo O. Respiratory syncytial virus lower respiratory tract infection induces acute pneumonia, cytokine response, airway obstruction and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in a murine model. J Infect Dis. 2004;189(10):1856-65. (* co-first author)
- Mejías A, Chávez-Bueno S, Ríos AM, Saavedra-Lozano J, Fonseca Aten M, Hatfield J, Kapur P, Gómez AM, Jafri HS and Ramilo O. Anti-RSV Neutralizing Antibody Decreases Lung Inflammation, Airway Obstruction And Airway Hyperresponsiveness in the Respiratory Syncytial Virus Murine Model. Antimicrobial Agents and Chemotherapy Antimicrob Agents Chemother. 2004;48(5):1811-22.
- Shalak LF, Laptook AR, Jafri HS, Ramilo O, Perlman JM. Clinical chorioamnionitis, elevated cytokines and brain injury in term infants. Pediatrics, 2002;110(4):673-80.
- Ghaffar F, Barton T, Lozano J, Muniz LS, Hicks P, Gan V, Ahmad N, McCracken, GH. Effect of the 7-valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization by Streptococcus pneumoniae in the first two years of life. Accepted for publication by Clinical Infectious Disease 2004.
- McCoig C, Castrejon M, Castano E, de Suman O, Baez C, Redondo W, McClernon D, Danehower S, Lanier R, Richardson C, Keller A, Hetherington S, Saez-Llorens X, Ramilo O. Effect of combination antiretroviral therapy on cerebrospinal fluid HIV RNA, HIV resistance and clinical manifestations of encephalopathy. J Pediatr 2002;141:36-44
- McCoig C, Castrejon M, Saavedra-Lozano J, Castano E, Baez C, Lanier R, Saez-Llorens X, Ramilo O. CSF and Plasma Concentrations of Pro-Inflammatory Mediators in Human Immunodeficiency Virus-Infected Children. Pediatr Infect Dis J 2004; 24:114-8
- Saavedra-Lozano J, Cao Y, Callison J, Sarode R, Sodora D, Edgar J, Hatfield J, Picker L, Peterson D, Ramilo O, Vitetta ES. An Anti-CD45RO Immunotoxin kills HIV latently-infected cells obtained from individuals on HAART with little effect on CD8 memory. Proc. Natl. Acad. Sci. USA 2004;101: 2494-9
- Mejías A, Chávez-Bueno S, Ríos AM, Saavedra-Lozano J, Fonseca-Aten M, Hatfield J, Kapur P, Gómez AM, Jafri HS, Ramilo O. Anti-RSV Neutralizing Antibody Decreases Lung Inflammation, Airway Obstruction And Airway Hyperresponsiveness in the Respiratory Syncytial Virus Murine Model. Antimicrobial Agents and Chemotherapy 2004;5:1811-22
- Gill MA, Palucka K, Barton T, Ghaffar F, Jafri H, Banchereau J, Ramilo O. Sustained Mobilization of Plasmacytoid and Myeloid Dendritic Cells to Mucosal Sites in Children with Respiratory Syncytial Virus Infection. Journal of Immunology (submitted)
- Ahmed, A., Jafri H, Lutsar I, McCoig CC, Trujillo M, Wubbel L, Shelton S, McCracken GH Jr. Pharmacodynamics of vancomycin for the treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. Antimicrob Agents Chemother, 1999. 43(4): p. 876-81.
- Ghaffar, F., Friedland IR, Katz K, Muniz LS, Smith JL, Davis P, Reynolds J, McCracken GH Jr. Increased carriage of resistant non-pneumococcal alpha-hemolytic streptococci after antibiotic therapy. J Pediatr, 1999. 135(5): p. 618-23.
- Lutsar, I., Friedland IR, Jafri HS, Wubbel L, Ng W, Ghaffar F, McCracken GH Jr. Efficacy of gatifloxacin in experimental Escherichia coli meningitis. Antimicrob Agents Chemother, 1999. 43(7): p. 1805-7.
- Hardy, R.D., Jafri HS, Olsen K, Wordemann M, Hatfield J, Rogers BB, Patel P, Duffy L, Cassell G, McCracken GH, Ramilo O. Elevated cytokine and chemokine levels and prolonged pulmonary airflow resistance in a murine Mycoplasma pneumoniae pneumonia model: a microbiologic, histologic, immunologic, and respiratory plethysmographic profile. Infect Immun, 2001. 69(6): p. 3869-76.
- Lutsar, I., Friedland IR, Jafri HS, Wubbel L, Ahmed A, Trujillo M, McCoig CC, McCracken GH Jr. Factors influencing the anti-inflammatory effect of dexamethasone therapy in experimental pneumococcal meningitis. J Antimicrob Chemother, 2003. 52(4): p. 651-5.
- Rodriguez-Cerrato, V., McCoig CC, Saavedra J, Barton T, Michelow IC, Hardy RD, Bowlware K, Iglehart J, Katz K, McCracken GH Jr. Garenoxacin (BMS-284756) and moxifloxacin in experimental meningitis caused by vancomycin-tolerant pneumococci. Antimicrob Agents Chemother, 2003. 47(1): p. 211-5.
- Michelow, I.C., Olsen K, Lozano J, Rollins NK, Duffy LB, Ziegler T, Kauppila J, Leinonen M, McCracken GH Jr. Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children. Pediatrics, 2004. 113(4): p. 701-7.
|
|
