Department of Pediatrics: Cardiology Research

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Basic Science

Within the Pediatric Cardiology division, a thriving research program examining the genetic bases of congenital heart defects is led by Dr. Deepak Srivastava, together with Dr. Vidu Garg, a pediatric cardiologist and junior faculty member in the group. Eight additional post-doctoral fellows training in cardiac development and seven graduate students obtaining their Ph.D. or M.D., Ph.D. degrees in Dr. Srivastava's laboratory provide a rich and interactive training environment. Frequent lab meetings, journal clubs and seminars are an integral part of their experience. Annual external grant support for studies related to cardiac development in the Pediatric Cardiology division exceeds $1 million, including support from National Institute of Health, March of Dimes and American Heart Association. This effort has resulted in numerous publications representing advances in our understanding of cardiac development and the genetic basis for congenital heart defects. For more details about the laboratory effort in Pediatric Cardiology, please visit the website: http://hamon.swmed.edu/~srivastavalab

In addition, a vast array of research opportunities is available in the area of cardiovascular biology, as UT Southwestern currently boasts one of the largest concentration of investigators in this exciting area of science, including: Eric Olson, Ph.D., Helen Hobbs, M.D., Tom Sato, Ph.D., Masashi Yanagisawa, M.D., Ph.D., Deepak Srivastava, M.D. and Daniel Garry, M.D. This critical mass has allowed the institution to successfully compete for selection as the single initial recipient of a $24 million Reynolds Foundation Grant for research in the cardiovascular sciences and a $15 million dollar Program in Genomic Applications grant from the National Heart Lung and Blood Institute. As a reflection of the rich atmosphere at UT Southwestern, the 2001 Weinstein Cardiovascular Development Conference was organized by Dr. Srivastava and brought over 300 investigators from around the world to present their work in Dallas. The core facilities, institutional programs and training atmosphere spawned from these center grants have created a unique atmosphere for trainees interested in new discovery.

Clinical Sciences

The Pediatric Cardiology Division also pursues numerous prospective clinical trials in an effort to bring evidence-based medicine to the care of children with heart disease. Such trials range from new approaches to close holes in the heart without open heart surgery to new methods of suppressing the cardiac damage induce by cardio-pulmonary bypass. Faculty participate in many multi-center clinical trials including ones for heart failure management and understanding the epidemiology and risk factors for congenital heart disease. Specific interests of each faculty member are listed.