Department of Pediatrics: Gastroenterology Faculty

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John M. Andersen, M.D.
Norberto Rodriguez-Baez, M.D.
Bradley A. Barth, M.D., M.P.H.
Andrew Feranchack, M.D.
Naveen Mittal, M.D.
Ashish Patel, M.D.
Michael A. Russo, M.D.
Gaith Semrin, M.D.

John M. Andersen, M.D.

Professor of Pediatrics, University of Texas Southwestern Medical Center
Director, Division of Pediatric Gastroenterology and Nutrition at UT Southwestern Medical School
Director, Center for Gastroenterology, Liver Disease and Nutrition, Children’s Medical Center of Dallas
Associate Medical Director for Pediatric Liver Transplantation, Dallas Liver Transplantation Program

Clinical Interests:

Liver Transplantation
Inflammatory Bowel Disease
Blue Rubber Bleb Nevus Syndrome
Cyclic Vomiting Syndrome
Treatment of Gastrointestinal Strictures/Narrowing

Research Studies/Interests:

Inflammatory Bowel Disease – Nutrition/Protein Synthesis
Gastroesophageal Reflux – Clinical Trials/Novel Therapies
Inflammatory Bowel Disease – Clinical Trials
Blue Rubber Bleb Nevus Syndrome – Novel Therapies
Cyclic Vomiting Syndrome – Novel Therapies
Esophageal Strictures – Novel Therapies

Recent Publications:

Andersen JM, Sugerman KS, Lockhart JR, Weinberg WA. Effective Prophylactic Therapy for Cyclic Vomiting Syndrome Using Amitriptyline and Cyproheptadine. Pediatrics, 1997; 100 (6): 977-981.

Andersen JM. Blue Rubber Bleb Nevus Syndrome. Current Treatment Options in Gastroenterology. 2001;33 #2:183-88
Elizondo B, Gonzalez D, Haslag S, Buchanan G, Burdick S, Guzzetta P, Hicks, B, Andersen J. Chronic Subcutaneous Octreotide Decreases Gastrointestinal Blood Loss in Blue Rubber Bleb Nevus Syndrome. J. Pediatr Gastroenterolo Nutr. 2001;4:433-40.

Norberto Rodriguez-Baez, M.D.

Assistant Professor of Pediatrics
Director of Fellowship Training Program
Coordinator of the Pediatric Resident Gastroenterology Elective
Coordinator of the Medical Student Gastroenterology Elective

Clinical Interests:

Viral hepatitis
Autoimmune hepatitis
Steatohepatitis
Liver Failure
Esophageal strictures

Research Studies/Interests:

A Multi-Center Group to Study Acute Liver Failure in Children
Principal Investigator at UTSMC since 2003
Sponsored by National Institutes of Health (2001-present)
A Multi-Center Study of the Safety and Efficacy of N-acetylcysteine in the Treatment of Acute Liver Failure Not Caused by Acetaminophen in Pediatric Patients
Principle Investigator at UTSMC since 2003 Sponsored by National Institutes of Health (2001-present)
Assessment of the Safety, Efficacy, Tolerability and Pharmacokinetics of PEG-Intron Plus REBETOL in Pediatric Patients With Chronic Hepatitis C
Sponsored by Schering-Plough Research Institute (2004)
Steatohepatits in Children
Treatment of Esophageal Strictures

Recent Publications:

Brundler MA, Rodriguez-Baez N, Jaffe R, Weinberg AG and Rogers B. Adenovirus Ascending Cholangiohepatitis. Pediatric and Developmental Pathology Vol. 6, No. 2: 156-9, March 2003
Rodriguez-Baez, N and Andersen JM. Management of Esophageal Strictures in Children. Current Treatment Options in Gastroenterology Vol.6 No.5: 417-425, October 2003.
Rodriguez-Baez N, O’Brien R, Qiu SQ and Bass DM. Astrovirus, Adenovirus, and Rotavirus in Hospitalized Children: Prevalence and Association With Gastroenteritis. Journal of Pediatric Gastroenterology and Nutrition Vol. 35, No. 1: 64-8, July 2002

Bradley A. Barth, M.D., M.P.H.

Assistant Professor of Pediatrics

Clinical Interests:

Therapeutic endoscopy
Capsule endoscopy
ERCP
Pancreatic and biliary tract disease
Inflammatory bowel disease

Research Studies/Interests:

Capsule Endoscopy in the evaluation of Pediatric Patients with Inflammatory Bowel Disease
Juvenile Polyposis
Therapeutic Endoscopy and ERCP in Children

Recent Publications:

Barth BA, Donovan K, Fox VL: Endoscopic Technique for Duodenal Placement of Video Capsule in Pediatric Patients. Gastrointest Endosc, In Press
Barth BA. Upper Gastrointestinal Bleeding. In: Quiros J, Kramer R, editors. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Fellows’ Handbook 2003.
Barth BA, Mobassaleh M. Acute Pancreatitis. In: Hochberg Z, editor. Practical Algorithms in Pediatric Gastroenterology. In press.

Andrew Feranchak, M.D.

Assistant Professor of Pediatrics

Clinical Interests:

General Pediatric Gastroenterology
Regulation of biliary secretion

Research Studies/Interests:

Hepatobiliary transport
Regulation of biliary secretion
Purinergic signaling in hepatobiliary function and cell volume regulation
Cystic fibrosis-associated liver and biliary disease
Assessment of fat-soluble vitamin status during cholestasis and cystic fibrosis

Recent Publications:

Feranchak AP, Roman RM, Salter KD, Toker A, Fitz JG. The lipid products of phosphoinositide 3-kinase contribute to regulation of cholangiocyte ATP and chloride transport. J. Biol. Chem. 1999; 274:30979-30986
Feranchak AP, Berl T, Capasso J, Wojtaszek PA, Han J, Fitz JG. P38 MAP Kinase modulates liver cell volume through inhibition of membrane Na permeability. J Clin Invest. 2001; 108:1495-1504.
Feranchak AP, Kilic G, Wojtaszek PA, Qadri I, Fitz JG. Volume-sensitive tyrosine kinases regulate liver cell volume through effects on vesicular trafficking and membrane Na permeability. J Biol Chem. 2003; 278(45):44632-8.

Ashish Patel, M.D.

Instructor of Pediatrics

Clinical Interests:

Inflammatory Bowel Disease
Growth in Inflammatory Bowel Disease
Celiac Disease

Research Studies/Interests:

Inflammatory Bowel Disease

Recent Publications:

Proton Pump Inhibitors and Pediatrics. PatelAS, Pohl J, Easley D: Pediatrics in Review. 2003; 24:12-15.
Acute Pancreatitis. PatelAS, Barth B. Pediatric Gastroenterology Fellow’s Handbook 2005.

Associate Professor of Pediatrics
Director of Pediatric Hepatology and Transplantation Program

Clinical Interests:

Liver and intestinal transplant
Biliary atresia
Liver disease in children
Short gut syndrome

Research Studies/Interests:

Liver Transplantation
Small Bowel Transplantation
Short gut Syndrome
Hepatitis/Portal Hypertension

Recent Publications:

Mittal, N., Tzakis, A., Kato, T., Thompson, J., Current status of small bowel transplantation in children: Update 2003. Pediatric Clinics of North America, Dec. 2003
Kato, T., Mittal, N., Nishida, S., Levi, D., Yamashiki, N., Miller, B., Gonzalez, M., Ruiz, P., Madariaga, J., Nery, J., Gelman, B., Thompson, J., Gyamfi, A., Tzakis, A., The role of intestinal transplantation in the management of babies with extensive gut resections, Journal of Pediatric Surgery, 38(2):145-9, 2003.
Mittal, N., Liver transplantation in children, Pediatrics Today, 4(1): 6-9, 2001.
Mittal, N., Thompson, J.F., Kato, T., Tzakis, A.G., Tacrolimus and Diarrhea: Pathogenesis of altered metabolism, Pediatric Transplantation, 5(2): 75-79, 2001.

Michael A. Russo, M.D.

Assistant Professor of Pediatrics

Clinical Interests:

Polyposis syndromes
Therapeutic endoscopy/Esophageal Dilatation
Celiac disease
Inflammatory Bowel Disease
Cystic Fibrosis

Research Studies/Interests:

Gastroesophageal Reflux – Novel Therapies
Endoscopic Clinical Outcomes Research Initiative (PEDS-CORI)

Recent Publications:

Russo MA, Redel CA. Anatomy, hepatology, endoscopy and developmental anomalies of the stomach and duodenum. In Feldman M, Friedman L, Sleisenger MH (eds): Gastrointestinal and Liver Disease, 8th ed. Philadelphia, WB Saunders, In Press
Russo MA, Ennis BJ, Redel CA. Infantile hepatic fibrosis: An usual manifestation of Down Syndrome and Abnormal Myelopoiesis. November 2004, Orlando, FL. American College of Gastroenterology Annual Meeting. Abstract and Poster Presentation
Russo MA, Hogenauer C, Coates Jr. S, Santa Ana CA, Porter JL, Rosenblatt RL, M Emmett, and Fordtran JS. Abnormal passive chloride absorption in cystic fibrosis jejunum functionally opposes the classic chloride secretory defect. J Clin Invest 2003;112: 118-125

Gaith Semrin, M.D.

Assistant Professor of Pediatrics

Clinical Interests:

Inflammatory Bowel Disease
General Pediatric Gastroenterology

Research Studies/Interests:

Inflammatory Bowel Disease

Recent Publications:

Pappa, Helen M.; Semrin, Gaith; Walker, Thomas R. (shared first authorship); Grand, Richard J., Pediatric inflammatory bowel disease. Current Opinion in Gastroenterology. 20(4):333-340, July 2004.
Gaith Semrin, Nancy C. Andrews, Athos Bousvaros, Richard J. Grand, Anna Zholudev, Andrew Saunders, David Weinstein. Impaired Intestinal Iron Absorption in Crohn’s Disease Correlates with Disease Activity and Inflammatory Cytokines. May 2004, New Orleans, LA, Digestive Disease Week. Clinical Science Oral Presentation.
Gaith Semrin, Nancy C. Andrews, Athos Bousvaros, Richard J. Grand, Anna Zholudev, Andrew Saunders, David Weinstein. Impaired Intestinal Iron Absorption in Crohn’s Disease Correlates with Disease Activity and Inflammatory Cytokines. July 2004, Paris France, World Congress Of Pediatric Gastroenterology, Hepatology And Nutrition. Poster Presentation