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Sarah Blumenschein, M.D.
V. Vivian Dimas, M.D.
Reenu Eapen, M.D.
David E. Fixler, M.D.
Vidu Garg, M.D.
Lisa C. Heistein, M.D.
Catherine Ikemba, M.D.
Matthew Lemler, M.D.
Lynn Mahony, M.D.
Claudio Ramaciotti, M.D.
William Scott, M.D.
Daniel Stromberg, M.D.
Tia Tortoriello, M.D.
Thomas Zellers, M.D.
Ilana J. Zeltser, M.D.
William Scott, M.D.
Professor of Pediatrics
Chief of Cardiology
Director of Electrophysiology
Medical Education: Indiana University School of Medicine
Cardiology Fellowship: University of Michigan, Ann Arbor, MI
Special Interests: Arrhythmias, interventional electrophysiology, pacemakers, syncope and neuromuscular disease
Recent Publications:
- Scott WA. Syncope and evaluation of the autonomic nervous system. In Moss & Adams’ Heart Disease in Infants, Children and Adolescents, Including the Fetus and Young Adult, edited by Emmanoulides, Reimenschneider, Allen & Gutgesell Baltimore, MD, Williams & Wilkins, 2001, pages 443-451.
- Scott WA and Iannacconne ST. Intensive care management including cardiorespiratory care. In Neuromuscular Disorders of Infancy, Childhood and Adolescence, A Clinician's Approach, edited by Jones De Vivo and Darras, MA, Butterworth Heinemann, 2003, pages 1237-1250.
- Saul JP, ScottW, Brown S, Marantz P, Etheridge S, Perry J, Triedman JK, Acevedo V, Burriss Cargo P, Wang R, Graepel J: Intravenous Amiodarone for Incessant Tachyarrhythmias in Children: A Randomized Double-Blinded Anti-Arrhythmic Drug Trial, Circulation, 2005;112:3470-3477.
- Scott WA. First and Second Degree Atrioventricular Block In Cardiac Electrophysiology in the Young, edited by Dick. Cambridge, MA, Springer, 2006
Current Projects:
- Heart Rate Turbulence in patients with Congenital Heart Disease
- Transthoracic Cardioversion of Atrial Flutter and Atrial Fibrillation in Pediatric Patients and Patients with Congenital Heart Disease: A Multicenter, Prospective Evaluation of Shock Requirements, Waveforms and Impedance
- Evaluation of non-contact electrocardiographic recording systems
- Signal averaged ECG to assess heart transplant rejection in pediatric patients
Indications for ICD implantation in pediatric patient
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Sarah Blumenschein, M.D.
Clinical Assistant Professor of Pediatrics
Director, Preventive Cardiology
Medical Education: Cornell University Medical College
Cardiology Fellowship: Duke University
Special Interests: Diagnosis and treatment of children with familial lipid disorders
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V. Vivian Dimas, M.D.
Assistant Professor of Pediatrics
Medical Education:University of Oklahoma College of Medicine
Cardiology Fellowship:Baylor College of Medicine/Texas Children’s Hospital
Advanced Training:Pediatric Heart Failure and Transplantation 4th year training in diagnostic/interventional catheterization Baylor College of Medicine Texas Children’s Hospital
Special Interests:Percutaneous therapies for the treatment of congestive heart failure.
Recent Publications:
- Dimas VV, Kovalchin JP, McKenzie ED, Kung GC. Infected Pseudoaneurysm of a Right Modified Blalock-Taussig Shunt. Pediatr Cardiol. 2004; 25(6): 700-701.
- Dimas VV, Grifka RG, Fraser CD. Combined Tricuspid Valvuloplasty and Superior
- Cavopulmonary Anastomosis for Repair of Traumatic Tricuspid Valve Injury. Tex Heart Inst J 2004; 31(4): 418-420.
- Dimas, VV, Taylor MD, Cunnygham CG, Overholt ED, Bourne DW, Stanley JR, Shiekh A, Wolf R, Valentine B, Ward KE. Transplacental Pharmacokinetics of Flecainide in the Gravid Baboon and Fetus. Pediatr Cardiol. 2005 Nov-Dec; 26(6): 815-20.
- Carlson KM, Justino H, O’Brien RE, Dimas VV, Leonard GT, Pignatelli RH, Mullins CE, Smith EO, Grifka RG. Transcatheter Atrial Septal Defect Closure: Modified Balloon Sizing Technique to Avoid Overstretching the Defect and Oversizing the Amplatzer Septal Occluder. Catheter Cardiovasc Interv. 2005 Nov; 66(3): 390-6.
- Kim JJ, Dreyer WJ, O’Brian Smith E, Price JF, Clunie S, Dimas VV, Jefferies JL, Rosenblatt H, Radovancevic B, Towbin JA, Denfield SW. Leukocyte suppression is associated with improved clinical outcomes in children’s status after orthotopic heart transplantation. J Heart Lung Transplant. 2006 Feb; 25(2): 195-9.
Current Project:
- Percutaneously placed assist devices, feasibility in animal models.
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Reenu Eapen, M.D.
Assistant Professor Pediatrics
Medical Education: The Ohio State University College of Medicine
Cardiology Fellowship: University of Texas Southwestern Medical Center
Cardiac Imaging Fellowship: Baylor College of Medicine
Special Interests: Fetal Echocardiography, Magnetic Resonance Imaging
Recent Publications:
Current Projects:
- Role of cardiac magnetic resonance imaging in assessment and management of pulmonary hypertension
- Development of an interdisciplinary protocol for diagnosis and management of pulmonary hypertension
- Evaluation of late cardiac toxicity of low dose anthracycline in leukemia survivors
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David E. Fixler, M.D.
Professor of Pediatrics
Chief of Cardiology
Medical Education: University of Chicago
Cardiology Fellowship: Children's Memorial Hospital, Chicago, IL, Cardiovascular Research Institute, University of California, San Francisco
Postdoctoral: University of London, MSc, Epidemiology
Special Interests: Hypertension, Kawasaki disease, heart transplantation
Recent Publications:
- McBride KL, Marengo L, Canfield M, Langlois P, FixlerDE & Bellmont. Epidemiology on non-complex left ventricular outflow tract obstruction malformations in Texas, 1999-2001 Birth Defects Research Par A: Clin & Mol Terat 2005;73:555-561.
- Gilboa SM, Mendola P, Olshan AF, Savitz DA, Loomis D, Herring AH, FixlerDE. Relationship between ambient air quality and selected birth defects, Seven County Study, Texas, 1997-2000. Am J Epidemiol. 2005 162(3):238-52.
- Ghaffar S, Caughy M, FixlerDE. Proximity to hazardous waste sited and congenital heart disease. Arch Environ Health. 2004;59:177-181.
Current Projects:
- 8 year survival among children with complex single ventricle defects born in Texas, 1996-2004: A population based study.
- Pulse oximetry screening of term newborns at 4 hours of age to detect asymptomatic cyanotic congenital heart disease
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Vidu Garg, M.D.
Assistant Professor Pediatrics
Medical Education: Jefferson Medical College
Cardiology Fellowship: University of Texas Southwestern Medical Center
Special Interests: Molecular mechanisms of normal and abnormal cardiac development
Recent Publications:
- Garg, V. “Insights into the Genetic Basis of Congenital Heart Disease”. Cellular Molecular Life Sciences. 2006;63(10):1141-1148.
- Garg, V., Muth, A.N., Ransom, J.F., Schluterman, M.K., Barnes, R., King, I.N., Grossfeld, P.D., and Srivastava, D. “Mutations in NOTCH1 Cause Aortic Valve Disease”. Nature 2005;437(7056):270-274.
- Garg, V. “Molecular Genetics of Aortic Valve Disease”. Curr Opin in Cardiology 2006;21(3):180-184.Garg, V., Muth, A.N., Ransom, J.F., Schluterman, M.K., Barnes, R., King, I.N., Grossfeld, P.D., and Srivastava, D. “Mutations in NOTCH1 Cause Aortic Valve Disease”. NatureJuly 17, 2005 (on line).
- Garg, V., Kathiriya, I.S., Barnes, R., Schluterman, M.K., King, I.N., Butler, C. A., Rothrock, C.R., Eapen, R.S., Hirayama-Yamada, K., Joo, K., Matsuoka, R., Cohen, J.C., and Srivastava, D. “GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5”. Nature 2003;424(6947):443-447
Current Projects:
- Molecular pathways for cardiac septa formation
- Molecular mechanisms for semilunar valvulogenesis and calcification
- Genetic testing of individuals and families with congenital heart disease
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Lisa Chi Heistein, M.D.
Assistant Professor Pediatrics
Medical Education:The Ohio State University College of Medicine
Cardiology Fellowship:University of Texas Southwestern Medical Center
Cardiac Imaging Fellowship: University of Texas Southwestern Medical Center
Special Interests: Echocardiography, Fetal Echocardiography
Recent Publications:
- Heistein LC, Ramaciotti C, Scott WA, Coursey M, Sheeran PW, Lemler MS. Chloral hydrate sedation for pediatric echocardiography: physiologic responses, adverse events, and risk factors. Pediatr 2006;117(3):e1-8.
- Ramaciotti C, Heistein LC, Coursey M, Lemler MS, Eapen RS, Iannaccone ST, Scott WA. Left ventricular function and response to enalapril in patients with Duchenne muscular dystrophy during the second decade of life. Am J Cardiol. 2006 Sep 15;98(6):825-7. Epub 2006 Aug 2.
- Heistein LC, Scott WA, Zellers TM, Fixler DE, Ramaciotti C, Journeycake JM, Lemler MS. Aspirin resistance in children with heart disease at risk for thromboembolism: prevalence and possible mechanisms. Submitted for publication Sep 2006.
Current Projects:
- Early detection of pulmonary hypertension in adolescents with sickle cell disease
- Safety of sedation in the echocardiography laboratory
- The psychological impact of fetal diagnosis of congenital heart disease
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Catherine Minor Ikemba, M.D.
Assistant Professor of Pediatrics
Medical Education: University of Southern California School of Medicine
Cardiology Fellowship: Baylor College of Medicine
Advanced Echo Fellowship: Baylor College of Medicine
Special Interests: General echocardiography, ventricular function
Recent publications:
- Ikemba CM, Su JT, Stayer SA, Miller-Hance WC, Eidem BW, Bezold LI, et al. Myocardial Performance Index with Sevoflurane/Pancuronium versus Fentanyl/Midazolam/Pancuronium in Infants with a Functional Single Ventricle. Anes 2004;101:1298-1305
- Ikemba CM, Eidem BW, Fraley JK, Eapen RS, Pignatelli R, Ayrea NA, et al. Mitral Valve Morphology and Morbidity/Mortality in Shone’s Complex. Amer J Card 2005;95:541-543
- Ikemba CM, Eidem BW, Dimas VV, O’Day MP. Fraser CD. Fetal Rhabdomyoma Causing Postnatal Critical Left Ventricular Outflow Tract Obstruction. In Press, Ann Thoracic Surgery 2005 Oct;80(4):1529
Current Projects:
- When is TEE required for evaluation of the atrial septum in the Pediatric populaton?
- The role of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in patients with suspected acute inflammatory cardiomyopathy
- The psychological impact of fetal diagnosis of congenital heart disease
- Imaging of anomalous left coronary artery
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Matthew Lemler, M.D.
Associate Professor of Pediatrics
Medical Education: University of Texas Medical Branch at Galveston
Cardiology Fellowship: University of Colorado Health Science Center
Special Interests: Echocardiography, evaluation of diastolic function
Recent Publications:
- Ghaffar S, Lemler M, Fixler D, Ramaciotti C. Trisomy 21 and congenital heart disease: Effect of timing of initial echocardiogram. Clin Ped 2005;44:39-42
- Lemler MS, Ramaciotti C, Stromberg D, Scott WA and Leonard SR. The extracardiac lateral tunnel Fontan, constructed with bovine pericardium: Comparison with the extracardiac conduit Fontan. Am Heart J, in press
- Heistein, LC, Ramaciotti C, Scott W, Coursey M, Sheeran PW, Lemler MS. Sedation for pediatric echocardiography: Physiologic responses, adverse events, and risk factors. Pediatrics, in press
Current Projects:
- Assessment of cardiac function in Duchenne muscular dystrophy
- Safety of sedation in the echocardiography laboratory
- Anticoagulation issues in congenital heart disease
- Pre and post operative risk factors for short and long term Fontan outcome
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Lynn Mahony, M.D.
Professor of Pediatrics
Director, Fellowship Program
Medical Education: Stanford University
Cardiology Fellowship: Cardiovascular Research Institute, University of California, San Francisco
Special Interests: Collaborative trials in pediatric cardiology, Marfan syndrome, cardiovascular evaluation of student athletes, treatment of myocardial dysfunction
Recent Publications:
- Stavinoha PL, FixlerDE, Mahony L. Cardiopulmonary bypass to repair an atrial septal defect does not affect cognitive function in children. Circulation 2003;107:2722-2725.
- Rosenthal D, Chrisant MRK, Edens E, Mahony L et al. Practice Guidelines for Management of Heart Failure in Children, J Heart Lung Transplantation 2004 Dec;23(12):1313-33.
- Mahony L, Sleeper LA, Anderson PAW, Gersony WM, McCrindle BW, Minich LL, Newburger JW, Saul JP, Vetter VL, Pearson GD. The Pediatric Heart Network: A Primer for the Conduct of Multicenter Studies in Children with Congenital and Acquired Heart Disease. Pediatr Cardiol, 2006;27:191-198.
- Sleeper LA, Anderson P, Hsu DT, Mahony L, McCrindle BW, Roth SJ, Saul JP, Williams RV, Geva T, Colan SD, Clark BJ. Design of a large cross-sectional study to facilitate future clinical trials in children with the fontan palliation. Am Heart J 2006;152:427-433.
Current Projects:
- Steering Committee Chair, Pediatric Heart Network (NHLBI)
- Use of carvedilol in children with dilated cardiomyopathy.
- Evaluation of the reliability, validity and responsiveness of the Pediatric Cardiac Quality of Life Inventory in children and adolescents with heart disease
- Open label study comparing administration Remicade with a second dose of intravenous gamma globulin to patients with Kawasaki disease with recurrent fever.
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Claudio Ramaciotti, M.D.
Professor of Pediatrics
Director, Echocardiography Laboratory
Medical Education: Faculdade de Medicina da Universidade Federal do Rio de Janeiro
Cardiology Fellowship: Children's Hospital of Philadelphia, Philadelphia, PA
Special Interests: Echocardiography, Fetal Echocardiography
Recent Publications:
- Heistein LC, Ramaciotti C, Scott WA, Coursey M, Sheeran PW, Lemler MS. Chloral hydrate sedation for pediatric echocardiography: physiologic responses, adverse events, and risk factors. Pediatrics 2006;117:e1-8.
- Koch J, Henslely G, Roy L, Brown S, Ramaciotti C, Rosenfeld CR. A prospective analysis characterizing the ductus arteriosus in in-born neonates ≤ 1000gm birth weight. Pediatrics 2006;117:1113-21.
- Ramaciotti C, Heistein LC, Coursey M, Lemler MS, Eapen RS, Iannaccone S, Scott WA. Ventricular function and response to Enalapril in patients with Duchenne Muscular Dystrophy during the second decade of life. Accepted for publication by the American Journal of Cardiology, April 2006.
Current Projects:
- Assessment of ventricular function in Duchenne muscular dystrophy
- Ventricular function during ECMO
- Right ventricular pressure and function in patients with sickle cell anemia
- Echocardiographic assessment surgical repair of congenital heart defects in the operating room
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Daniel Stromberg, M.D.
Associate Professor of Pediatrics
Medical Education: University of California, San Francisco
Cardiology Fellowship: Baylor College of Medicine
Special Interests: Critical care, mechanical circulatory support, heart transplantation, transesophageal
echocardiography
Recent Publications:
- Stromberg D, Tortoriello T, Adame T. Waiver of Prospective Consent in Pediatric Resuscitation Research. Pediatrics 2005;115:828-9.
- Mou SS, Giroir BP, Kirsch EA, Nizzi F, Leonard SR, Nikaidoh H, Roy LC, Town DA, Scott W, Stromberg D. Fresh Whole Blood versus Reconstituted Blood for Pump Priming in Heart Surgery in Infants. N Engl J Med 2004;351:1635-44.
- Ma W, Shang-Feaster G, Town D, Giroir B, Stromberg D. Usefulness of External Counterpulsation Early Postoperatively After the Fontan Procedure in Children. American Journal of Cardiology 2002;90(9):1029-31.
Current Projects:
- Randomized clinical trial of pediatric interposed abdominal compression CPR.
- Effect of Thymosin B4 on myocardial dysfunction in a rat resuscitation model
- Role of Inflammatory Processes in Postoperative Fontan Patients
- rBPI21 (Neuprex) in children undergoing cardiopulmonary bypass: a phase II/ III, randomized, double-blind placebo controlled trial.
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Tia Tortoriello, M.D.
Assistant Professor of Pediatrics
Medical Education: University of Texas Southwestern Medical Center at Dallas
Cardiology Fellowship: Baylor College of Medicine
Advanced Critical Care Training: Baylor College of Medicine
Special Interests: Critical care, myocardial inflammation
Recent Publications:
- Mott AR, Alomrani A, Tortoriello TA, Perles Z, East D, Stayer SA. “Changes In Cerebral Saturation Profile In Response To Mechanical Ventilation Alterations In Infants With Bidirectional Superior Cavopulmonary Connection.” Pediatric Critical Care Medicine, 2006;7:346-350.
- Stromberg D, Tortoriello TA, Adame T. “Waiver of Prospective Consent for Pediatric Resuscitation Research.” Pediatrics, 2005;115:828-829.
- Tortoriello TA, Stayer SA, Mott AR, McKenzie ED, Fraser CD, Andropoulos DB, Chang AC. “A Noninvasive Estimation of Mixed Venous Oxygen Saturation Using Near-Infrared Spectroscopy by Cerebral Oximetry in Pediatric Cardiac Surgery Patients.” Pediatric Anesthesia 2005;15:495-503.
- Tortoriello, TA: The Hemodynamic Response in Heart Failure. In: Heart Failure in Children and Young Adults: From Molecular Mechanisms to Medical and Surgical Strategies, Chang AC and Towbin J (editors). 2005 Saunders Elsevier Inc., pp 60-84.
Current Projects:
- Trial of Right Ventricle vs. Modified Blalock-Taussig Shunt in Infants with Single Ventricle Defect Undergoing Staged Reconstruction
- The National Registry of Cardiopulmonary Resuscitation Database at Children's Medical Center of Dallas
- The role of matrix metalloproteinases and tissue inhibitors of metalloprotineases in children with acute inflammatory cardiomyopathy and in those undergoing cardiopulmonary bypass
- Pediatric Interposed Abdominal Compression CPR: A Randomized Clinical Trial
- Utility of Thromboelastography During Pediatric Extracorporeal Membrane Oxygenation: A Prospective Cohort Study
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Thomas Zellers, M.D.
Professor of Pediatrics
Director, Cardiac Catheterization Laboratory
Medical Education: University of Texas Southwestern Medical Center at Dallas
Cardiology Fellowship: Mayo Clinic
Interventional Cardiac Catheterization Fellowship: Baylor College of Medicine
Special Interests: Interventional cardiology, selective pulmonary vasodilator therapy, adults with congenital heart disease
Recent Publications:
- Ramaciotti C, Lemler MS, Moake L, Zellers TM. Comprehensive assessment of PDA by echocardiography prior to transcatheter closure of a small patent ductus arteriosus. Journal of the American Society of Echocardiography, 15:1154-9, 2002.
- Du ZD, Hijazi ZM, Kleinman CS, Silverman NM, Larntz K, and Amplatzer investigators (Zellers TM listed with 14 other investigators). Comparison between transcatheter and surgical closure of secundum atrial septal defect in children and adults. J Amer Coll Card 2002; 39(11):1836-1844.
- Pass RH, Hijazi ZM, Hsu DT, Lewis V, Hellenbrand WE, Zellers TM as Amplatzer Investigators. Multicenter USA Amplatzer Patent Ductus Arteriosus Occlusion Device Trial. J Amer Coll Card, 44(3) 513-9, 2004
Current Projects:
- Prospective, randomized trial using the Neptune patch vs standard gauze for post catheterization hemostasis
- Phase II FDA trial for transcatheter PDA closure using the PFM Nit-Occlud device
- Multicenter prospective trial of surgery vs balloon angioplasty vs stenting for aortic coarctation (CCISC trial
- Intravascular stents in aorta and pulmonary arteries; effect on endothelial function and vascular healing over time.
- Bioreabsorbale stents in large arteries and veins (collaboration with Dr. Robert Eberhardt PhD)
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Ilana J. Zeltser MD
Assistant Professor of Pediatrics
Medical Education: New York University School of Medicine
Cardiology Fellowship: Children’s Hospital of Philadelphia
Electrophysiology Fellowship: Children’s Hospital of Philadelphia
Special Interests: Electrophysiology
Recent Publications:
- Zeltser I, Gaynor JW, Petko M, Myung RJ, Birbach M, et al. The roles of chronic pressure and volume overload states in induction of arrhythmias: An animal model of physiologic sequelae after reapir of tetralogy of Fallot. JTCVS; Dec 2005: 1542- 1548.
- Zeltser I, Menteer JD, Gaynor JW, Clark BJ, Kreutzer J, and Rome JJ. Impact of Recoarctation Following Norwood Operation on Survival in Balloon Angioplasty Era. J Amer Coll Card: 54 (11); 1844-8.
- Zeltser I, Jarvik GP, Bernbaum J, Gerdes M, Wenovsky G, Zackai E, Clancy RR, Nicolson SC, Spray TL, and Gaynor JW. Genetic Factors are Important Determinants of Neurodevelopmental Outcome After Repair of Tetralogy of Fallot. Abstract published in Circulation 2004; 110 (17): III-389. Manuscript in Progress
Current Projects:
- Etiology of Arrhythmias following repair of Tetralogy of Fallot (TOF): Chronic Volume versus Pressure Overload
- Resynchronization Therapy
- Evaluation of novel electrocardiographic recording systems
- Use of Implantable Cardiac Defibrillator (ICD) as Primary Prevention of Sudden Cardiac Death in Children and Young Adults
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