We are investigating the molecular mechanisms of lipodystrophies for both the genetic and acquired varieties. Opportunities are available to study the mechanisms by which recently identified gene defects cause lipodytrophies. These include creating knock-out and transgenic mice models, modification at the cellular levels and the biochemistry behind such defects. Because of the genetic heterogeneity of the lipodystrophies, identification of additional gene will become necessary using positional cloning approaches. The lab is well equipped to carry out such experiments. This includes ABI-377 and ABI-7700, cell culture equipment and imaging systems. In addition, we utilize UT Southwestern's several core laboratories which include DNA sequencing, molecular imaging, transgenic as well as microarray facilities.