NAME OF LABORATORY
In vivo spectroscopy for metabolic diseases
RESEARCH INTERESTS
Development of noninvasive, spectroscopic tests for ectopic triglyceride with applications to myocardium skeletal muscle and liver.
Research in the field of prevention of diabetes and heart failure.
RESEARCH PROJECTS
Validation of myocardial triglyceride in vivo in respect to: obesity, ethnicity, gender, and diabetes.
Response of myocardial triglyceride to pharmacological interventions or life style changes.
In vivo metabolism of hepatic triglyceride.
PERSONNEL
Daniel Hernandez
COLLABORATIONS
Wanpen Vongpatanasin MD
Robert Dobbins MD, PhD
Roger Unger MD
Abhimanyu Garg MD
Khashayar Sakhaee MD
Gloria Vega PhD
Philip Raskin MD
ONGOING RESEARCH PROJECTS
Myocardial triglyceride in vivo
Principal Investigator: Lidia S. Szczepaniak, Ph.D.
Agency: National Institutes of Health
Dates: October 01, 2002-September 31, 2007
The aim of this project is to determine the role of triglyceride deposits within myocardial cells with a focus on the development of cardiac spectroscopy to evaluate relationship between triglyceride content within cardiac muscle and myocardial function.
RECENT PUBLICATIONS
1. Szczepaniak LS, Babcock EE, Schick F, Dobbins RL, Garg A, Burns DK, McGarry JD, Stein DT. Measurement of intracellular triglyceride stores by H1 spectroscopy: validation in vivo. Am J Physiol. 1999 May; 276(5 Pt 1):E977-89.
2. Szczepaniak LS, Dobbins RL, Metzger GJ, Sartoni-D'Ambrosia G, Arbique D, Vongpatanasin W, Unger R, Victor RG. - Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn Reson Med. 2003 Mar;49(3):417-23.
3. Szczepaniak LS, Dobbins RL, Stein DT, McGarry JD - Bulk magnetic susceptibility effects on the assessment of intra- and extra-myocellular lipids in vivo. Magn Reson Med. 2002 Mar; 47(3):607-10.
4. Simha V, Szczepaniak LS, Wagner AJ, DePaoli AM, Garg A. - Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. Diabetes Care. 2003 Jan;26(1):30-5.
5. Nurenberg P, Sartoni-D'Ambrosia G, Szczepaniak LS - Magnetic resonance spectroscopy of renal and other retroperitoneal tumors. Curr Opin Urol. 2002 Sep;12(5):375-80.
6. Reingold JS, McGavock JM, Kaka S, Tillery T, Victor RG, Szczepaniak LS - Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy; reproducilbility and sensitivity of the method. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E935-9.
7. Browning JD, Szczepaniak LS, Dobbins R, Nurenberg \P, Horton JD, Cohen JC, Grundy SM, Hobbs HH - Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004 Dec; 40(6):1387-95.
8. Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, Hobbs HH, Dobbins RL - Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalance of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab. 2005 Feb; 288(20:E462-8.
IMPORTANT PUBLICATIONS
1. Dobbins RL, Szczepaniak LS, Zhang W, McGarry JD - Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion. Am J Physiol Endocrinol Metab. 2003 Apr; 284(4):E778-87
2. LS Szczepaniak, EE Babcock, AD Sherry, C Malloy - Oxidation of acetate in rabbit skeletal muscle: detection by 13C NMR spectroscopy in vivo. MRM 36, 451 (1996)
3. LS Szczepaniak, A Sargeson, M Tweedle, RG Bryant - Nuclear Magnetic Spin-Relaxation of Water Protons Caused by Metal Cage Compounds. Bioconjugate Chemistry 3, 27 (1992)
4. LS Szczepaniak, RG Bryant - Proton Nuclear Relaxation in Aqueous Copper(II) Amine Chelate Solutions - Inorganica Chimica Acta - 184, 7 (1991)
