NAME OF LABORATORY

In vivo spectroscopy for metabolic diseases

RESEARCH INTERESTS

Development of noninvasive, spectroscopic tests for ectopic triglyceride with applications to myocardium skeletal muscle and liver.

 

Research in the field of prevention of diabetes and heart failure.

RESEARCH PROJECTS

Validation of myocardial triglyceride in vivo in respect to: obesity, ethnicity, gender, and diabetes.

Response of myocardial triglyceride to pharmacological interventions or life style changes.

In vivo metabolism of hepatic triglyceride.

PERSONNEL

Angela Lynn Price, M.D., Research Fellow

 

COLLABORATIONS

Wanpen Vongpatanasin MD
Roger Unger MD
Abhimanyu Garg MD
Khashayar Sakhaee MD
Gloria Vega PhD
Philip Raskin MD

RECENT PUBLICATIONS

1. Vega GL, Chandalia M, Szczepaniak LS, Grundy SM.  Effects of N-3 fatty acids on hepatic triglyceride content in humans.  J Investig Med 56(5):780-5, June 2008

2. Szczepaniak LS, Victor RG, Orci L, Unger RH.  Forgotten but not gone:  the rediscovery of fatty heart, the most common unrecognized disease in America.  Circ Res, 101(8):759-67, October 2007.

3. Zib I, Jacob AN, Lingvay I, Salinas K, McGavock JM, Raskin P, Szczepaniak LS.  Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes.  J Investig Med 55(5):230-6, July 2007.

4. McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R, Levine BD, Raskin P, Victor RG, Szczepaniak LS.  Cardiac steatosis in diabetes mellitus:  a 1H-magnetic resonance spectroscopy study.  Circulation.  116(10):1170-5, September 2007.

5. Lingvay I, Raskin P, Szczepaniak LS.  Effect of insulin-metformin combination on hepatic steatosis in patients with type 2 diabetes.  J Diabetes Complications, 21(3):137-42, May 2007.

IMPORTANT PUBLICATIONS

1. Dobbins RL, Szczepaniak LS, Zhang W, McGarry JD - Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion.  Am J Physiol Endocrinol Metab. 2003 Apr; 284(4):E778-87

2. LS Szczepaniak, EE Babcock, AD Sherry, C Malloy - Oxidation of acetate in rabbit skeletal muscle: detection by 13C NMR spectroscopy in vivo. MRM 36, 451 (1996)

3. LS Szczepaniak, A Sargeson, M Tweedle, RG Bryant - Nuclear Magnetic Spin-Relaxation of Water Protons Caused by Metal Cage Compounds. Bioconjugate Chemistry 3, 27 (1992)

4. LS Szczepaniak, RG Bryant - Proton Nuclear Relaxation in Aqueous Copper(II) Amine Chelate Solutions - Inorganica Chimica Acta - 184, 7 (1991)