| Ad Title: |
A Randomized, Phase II/III, Study of TNFerade Biologic with 5-FU and Radiation Therapy for First-Line Treatment of Unresectable Locally Advanced Pancreatic Cancer |
| Study Title: |
A Randomized, Phase II/III Study of TNFerade Biologic with 5-FU and Radiation Therapy for First-Line Treatment of Unresectable Locally Advanced Pancreatic Cancer |
| Protocol Number: |
082007-088 |
| Department(s) involved in the Study: |
Int Med - Hematology, Student Affairs
|
| Purpose of the Study: |
To determine wheter TNFerade biologic, when administered concurrently with standard of care (5-FU/radiation therapy followed by gemcitabine or gemcitabine/erlotinib maintenance therapy) improves 12-month survival rate as compared to standard of care alone. |
| Participant Eligibility: |
Interested individuals must be 18 or older with unresectable, locally advanced adenocarcinoma of the pancreas proven by biopsy or cytology who have not received previous treatment for pancreatic cancer, have a Karnofsky Performance Status of 70% or greater, life expectancy greater than 3 months, measurable disease and sign informed consent. Must be compliant with all study requirements. Spanish speaking patients are eligible to participate. |
| Disease/Condition Under Study: |
Unresectable locally advanced adenocarcinoma of the pancreas |
| Cancer Related Study: |
Yes
|
| Study Drug(s): |
Adrucil, Efudex, 5-Fluorouracil, TNFerade (AdGVEGR.TNF.11D)
|
| Study Device(s): |
|
| Study Doctor: |
Dr. Yull Arriaga |
| Location of Study: |
|
Sites
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Recruiting at this Site
|
|
Parkland Memorial Hospital
|
Yes
|
|
UT Southwestern University Hospitals St. Paul Building
|
Yes
|
|
UT Southwestern University Hospitals Zale Lipshy Building
|
Yes
|
|
Aston Ambulatory Care Center
|
Yes
|
|
UT Southwestern Moncrief Cancer Center, UT Southwestern Medical Center
|
Yes
|
|
| Contact Phone: |
214-648-5107 |
| Email: |
dendra.vonmerveldt@utsouthwestern.edu |
| Other Information: |
|
| Website Keywords: |
GI Cancer
|
| Medical Keywords: |
Adenocarcinoma, Pancreas, Pancreatic Cancer
|
