| Ad Title: |
A Pilot Study of Pioglitazone as Second Line Therapy for Patients with Previously Treated Metastatic Adenocarcinoma of the Pancreas with Disease Progression After Gemcitabine Based Chemotherapy |
| Study Title: |
A Pilot Study of Pioglitazone as Second Line Therapy for Patients with Previously Treated Metastatic Adenocarcinoma of the Pancreas with Disease Progression After Gemcitabine Based Chemotherapy |
| Protocol Number: |
112008-018 |
| Department(s) involved in the Study: |
Int Med - Hematology, Student Affairs
|
| Purpose of the Study: |
To describe changes in markers of insulin resistance, weight, ECOG Performance Status, and symptoms and quality of life using the FACT-Hep scale while determining tumor response by RECIST and time to disease progression in patients with previously treated metastatic pancreatic cancer receiving pioglitazone as second line therapy. |
| Participant Eligibility: |
Eligible participants must be 18 years or older, be previously treated metastatic adenocarcinoma of the pancreas patients with disease progression after gemcitabine-based chemotherapy. Histological or cytological confirmation of pancreatic cancer at initial diagnosis is required. Must have radiologically measurable disease and ECOG performance status of 0-2, adequate bone marrow, hepatic and renal function. Interested individuals must be able to understand the nature of the study and sign informed consent, use approved contraceptive methods during the trial and three months afterwards. Spanish speaking patients are eligible for participation. |
| Disease/Condition Under Study: |
Metastatic adenocarcinoma of the pancreas |
| Cancer Related Study: |
No
|
| Study Drug(s): |
Pioglitazone (Actos)
|
| Study Device(s): |
|
| Study Doctor: |
Dr. Yull Arriaga |
| Location of Study: |
|
Sites
|
Recruiting at this Site
|
|
Parkland Memorial Hospital
|
Yes
|
|
UT Southwestern University Hospitals St. Paul Building
|
Yes
|
|
UT Southwestern University Hospitals Zale Lipshy Building
|
Yes
|
|
Aston Ambulatory Care Center
|
Yes
|
|
UT Southwestern Medical Center
|
Yes
|
|
| Contact Phone: |
214-648-5107 |
| Email: |
dendra.vonmerveldt@utsouthwestern.edu |
| Other Information: |
|
| Website Keywords: |
GI Cancer
|
| Medical Keywords: |
GI Cancer, Pancreatic Cancer, Quality of Life
|
