| Ad Title: |
Genetics of Papilloma-Induced Voice Disturbance |
| Study Title: |
Genetics of Papilloma-Induced Voice Disturbance |
| Protocol Number: |
062004-061 |
| Department(s) involved in the Study: |
Otolaryngology
|
| Purpose of the Study: |
The purpose of this study is to discover the genetic elements that confer susceptibility to the unfortunate people who acquire recurrent respiratory papillomatosis. Many people are exposed to the causative virus, human papillomavirus 6 and 11 yet only a small fraction of these people develop the disease. Furthermore the disease displays a very wide range of aggressiveness. Determining the genetic basis of susceptibility to HPV will provide insight into the fundamental pathophysiology of RRP and papilloma infections in general. This in turn will facilitate development of rational therapy. |
| Participant Eligibility: |
All individuals who were diagnosed with recurrent respiratory papillomatosis before the age of 18 years are eligible for recruitment irrespective to their sex, ethnicity or other current diseases. Their biological parents will also be eligible. If a parent is unwilling or unable to participate then the patient?s biological siblings who share the missing parent will be eligible to participate.
If a patient in remission wishes to participate, then blood will be drawn by standard venipuncture but no papilloma specimen will be obtained.
|
| Disease/Condition Under Study: |
Recurrent Respiratory Papillomatosis |
| Cancer Related Study: |
No
|
| Study Drug(s): |
|
| Study Device(s): |
|
| Study Doctor: |
Dr. John McClay |
| Location of Study: |
|
Sites
|
Recruiting at this Site
|
|
Children's Medical Center
|
Yes
|
|
| Contact Phone: |
214_648_9793 |
| Email: |
barbara.staves@utsouthwestern.edu |
| Other Information: |
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| Website Keywords: |
Pediatrics, Pulmonary
|
| Medical Keywords: |
HPV, Papilloma
|
