Asthma and Depression

Clinical Trials :: Asthma and Depression

Ad Title:

Study Title:

Escitalopram in the Treatment of Outpatients with Severe Asthma and Moderate or Severe Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial

Protocol Number:

092007-057

Department(s) involved in the Study:

Psychiatry

Purpose of the Study:

The purpose of the study is to determine if: 1) Escitalopram treatment will be associated with less oral corticosteroid use than placebo in outpatients with severe asthma and moderate or severe major depressive disorder (MDD). 2) Escitalopram treatment will be associated with greater improvement in asthma symptoms than placebo in outpatients with severe asthma and moderate or severe MDD. 3) Escitalopram treatment will be associated with greater depressive symptom remission rates than placebo in outpatients with severe asthma and moderate or severe MDD.

Participant Eligibility:

The study is open to men and women age 18-70 years old, English or Spanish speaking. Participants must meet the diagnosis of moderate or severe major depressive disorder on the SCID and confirmed by interview with PI (Principle Investigator) or co-I (Co-Investigator). Participants must also meet a current diagnosis of having severe asthma. Participants will also need to have taken ≥ 3 courses of oral corticosteroids, for asthma, in the past 12 months.

Disease/Condition Under Study:

Moderate or severe major depressive disorder and Severe asthma.

Cancer Related Study:

Study Drug(s):

Study Device(s):

Study Doctor:

Dr. Edson Brown

Location of Study:

Sites	Recruiting at this Site
Parkland Memorial Hospital	Yes
Aston Ambulatory Care Center	Yes
UT Southwestern Medical Center, Other: See Comments	Yes

Contact Phone:

214_645_6950

Email:

Sherwood.Brown@Utsouthwestern.Edu

Other Information:

Website Keywords:

Psychiatry

Medical Keywords:

Asthma, Depression