| Ad Title: |
Citicoline Add-On Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence |
| Study Title: |
A Double-Blind, Placebo-Controlled Pilot Study of Citicoline Add-On Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence |
| Protocol Number: |
052006-027 |
| Department(s) involved in the Study: |
Psychiatry
|
| Purpose of the Study: |
The primary purposes of this study are to determine if citicoline add-on supplementation is associated with greater improvement in depressive symptoms than placebo in persons with bipolar (depressed phase) or major depressive disorder and amphetamine abuse/dependence. Additionally, this study is examining whether citicoline add-on supplementation is associated decreased amphetamine use and craving than placebo in persons with bipolar (depressed phase) or major depressive disorder and amphetamine abuse/dependence. This study is also investigating if citicoline add-on supplementation is associated with greater improvement in cognition than placebo in persons with bipolar (depressed phase) or major depressive disorder and amphetamine abuse/dependence. |
| Participant Eligibility: |
Men and women ages 18-70 years
Meeting criteria for a current major depressive episode (bipolar I, II, NOS, depressed phase) or major depressive disorder on the SCID with a duration of at least 4 weeks
Meeting criteria for amphetamine abuse or dependence with use within 14 days prior to baseline
No psychotropic medication changes within 14 days prior to study entry
|
| Disease/Condition Under Study: |
Bipolar disorder, depression, amphetamine dependence |
| Cancer Related Study: |
No
|
| Study Drug(s): |
Citicoline
|
| Study Device(s): |
|
| Study Doctor: |
Dr. Edson Brown |
| Location of Study: |
|
Sites
|
Recruiting at this Site
|
|
Parkland Memorial Hospital
|
Yes
|
|
UT Southwestern Medical Center
|
Yes
|
|
| Contact Phone: |
214_645_6950 |
| Email: |
Sherwood.Brown@Utsouthwestern.Edu |
| Other Information: |
|
| Website Keywords: |
Psychiatry
|
| Medical Keywords: |
amphetamine dependence, biploar disorder, citicoline, depression
|
