| Ad Title: |
Cognitive Treatment in Schizophrenia |
| Study Title: |
RCBF Correlates of Cognitive Treatments in Schizophrenia |
| Protocol Number: |
0803-476 |
| Department(s) involved in the Study: |
Psychiatry
|
| Purpose of the Study: |
This research is being done because people with schizophrenia often have problems with thinking including learning, remembering, paying attention, and problem solving. During this study, we will test if cognitive remediation (computer games made to improve thinking), used along with a drug called atomoxetine, may help the problems in thinking as well as some of the symptoms of schizophrenia. We will also see how cognitive remediation and atomoxetine affect the brain by studying blood flow in the brain. Functional magnetic resonance imaging (fMRI), a method used to take pictures of the brain without using radiation, will be used to see the patterns of blood flow in the brain while study participants are performing thinking tasks. |
| Participant Eligibility: |
CRITERIA FOR INCLUSION OF SUBJECTS:
-DSM-IV diagnosis of schizophrenia or schizoaffective disorder.
-Males and females.
-Ages 18-60 years old.
-All races and ethnicities.
CRITERIA FOR EXCLUSION OF SUBJECTS:
-Diagnosis of an organic brain disease.
-Diagnosis of DSM-IV alcohol or substance abuse with the last month or DSM-IV alcohol or substance dependence within the last 3 months.
-Meet criteria for primary negative symptoms, established by clinical judgment.
-Current or past history of clozapine treatment for antipsychotic non-response.
-Patients hospitalized within the previous 30 days.
-Colorblindness.
-Concurrent treatment with electroconvulsive therapy or psychotherapy.
-Pregnant women.
-Must be able to read, speak, and understand English. |
| Disease/Condition Under Study: |
Schizophrenia |
| Cancer Related Study: |
No
|
| Study Drug(s): |
atomoxetine
|
| Study Device(s): |
|
| Study Doctor: |
Dr. Carol Tamminga |
| Location of Study: |
|
Sites
|
Recruiting at this Site
|
|
Dallas County Mental Health, UT Southwestern Medical Center
|
Yes
|
|
| Contact Phone: |
214-648-5283 |
| Email: |
Debra.Moore@UTSouthwestern.edu |
| Other Information: |
|
| Website Keywords: |
Mental Health, Psychiatry
|
| Medical Keywords: |
Imaging, Schizophrenia
|
