| Ad Title: |
FUCHS Corneal Dystrophy Study |
| Study Title: |
A Multi-center Study to Map Novel Genes for Fuchs' Endothelial Corneal Dystrophy |
| Protocol Number: |
032006-047 |
| Department(s) involved in the Study: |
Ophthalmology
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| Purpose of the Study: |
The purpose of this multi-center study is to determine the genetic basis for the most common corneal dystrophy in the United States, Fuchs Endothelial Corneal Dystrophy (FECD). Severely affected patients who have undergone corneal transplantation surgery for this condition are asked to contact their siblings (and other relatives) for a screening visit. In addition, the affected patient along with potential relatives will have their blood drawn for genetic analysis in order to determine which gene(s) may have an influence in the development of this corneal disease. |
| Participant Eligibility: |
Due to the genetic nature of this trial, the following conditions must be met for a patient and their relative(s) to be considered for this study:
Affected patient must be 18 years or older
Affected patient must have a diagnosis of FUCHS and had corneal transplantation surgery or is scheduled to have corneal transplantation surgery in the near future.
Affected patient must have at least one relative with or without condition. It is preferred that affected patient has siblings such as sister and/or brother from the same set of parents. It is more preferable to have a relative with the same affected eye disorder.
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| Disease/Condition Under Study: |
Corneal Dystrophy
FUCHS Corneal Dystrophy
Endothelial Corneal Dystrophy |
| Cancer Related Study: |
No
|
| Study Drug(s): |
|
| Study Device(s): |
|
| Study Doctor: |
Dr. V. Vinod Mootha |
| Location of Study: |
|
Sites
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Recruiting at this Site
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|
Aston Ambulatory Care Center
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Yes
|
|
UT Southwestern Medical Center
|
Yes
|
|
| Contact Phone: |
214-645-2015 |
| Email: |
Monica.Mendez@UTSouthwestern.edu |
| Other Information: |
Fuchs Endothelial Corneal Dystrophy (FECD) is a condition that affects the inner layer (endothelium) of the cornea, which is the clear front part of the eye that allows light rays to enter the eye. FECD is slightly more common in women than in men. It is estimated that on average, half of the family members of a FECD patient may carry a gene for or suffer from the condition. Early signs of FECD can be seen by the doctor in people as young as their 30s but the dystrophy rarely affects vision until people reach their 50s. FECD cannot be cured. Treatment for the disease includes medications to reduce swelling and improve blurred vision and corneal transplantation surgery.
For more information, please contact Ms. Monica Mendez at UTSW Medical Center at Dallas. 214-645-2015 or Monica.Mendez@UTSouthwestern.edu
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| Website Keywords: |
Ophthalmology
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| Medical Keywords: |
Blurred Vision, Cornea Disease, Cornea Dystrophy, Endothelial Cornea, Eye Disease, Eye Pain, Fuchs, Genetic eye study, Inflammation of the cornea, Inflammation of the eye, Ocular, Poor Vision
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