Our research is focused on determining the mechanistic basis for the development of type II diabetes as it relates to cellular dysfunction in adipocytes, beta cells and hepatocytes. We aim to develop novel therapeutic approaches to improve insulin sensitivity
RESEARCH INTERESTS
Adipocytes
Beta Cells
Angiogenesis
Breast Cancer
Intracellular Protein Trafficking
RECENT PUBLICATIONS
Kim,J-Y, van de Wall,E., Laplante,M., Azzara, A., Trujillo,M.E., Hofmann,S.M., Schraw, T.D., Durand,J.L., Li,H., Li,G., Jelicks,L..A., Mehler,M.F., Hui,D.Y., Deshaies,Y., Shulman,G.I., Schwartz,G.J., P.E. SCHERER, "Obesity-Associated Improvements in Metabolic Profile in Mice: Rescue of the Diabetic Phenotype Through Expansion of Adipose Tissue Mass" Journal of Clinical Investigation, 117(9):2621-2637, 2007
Basu,R., Pajvani,U.B., Rizza, R.A., P.E. SCHERER, "Selective Downregulation of the High Molecular Weight form (HMW) of Adiponectin in Hyperinsulinemia and in Type 2 Diabetes: Differential Regulation from Non-diabetic Subjects" Diabetes, 56(8):2174-2177, 2007
Wang, Z.V., Schraw, T.D., Kim, J-Y., Khan, T., Rajala, M.W., Follenzi, A., P.E. SCHERER, "Secretion of the Adipocyte-Specific Secretory Protein Adiponectin Critically Depends on Thiol-Medicated Protein Retention" Molecular Cell Biology, (10):37:3716-3731, 2007
Kusminski, C.M., McTernan, P.G., Schraw, T., Kos, K., O’Hare, J.P., Ahima, R., P.E. SCHERER, "Adiponectin Complexes in Human Cerebrospinal Fluid: Distinct Complex Distribution from Serum" Diabetologia, 50(3):634-642, 2007
SIGNIFICANT PUBLICATIONS
Wernstedt-Asterholm, I., Halberg, N., P.E. SCHERER, "Mouse Models of Lipodystrophy - Key Reagents for the Understanding of the Metabolic Syndrome" Drug Discovery Today: Diease Models, in press 2007
Wang, Z.V., P.E. SCHERER, "Adiponectin, Cardiovascular Fundtion and Hypertension" Hypertension, in press 2007
Desruisseaux, M.S., Nagajyothi, Trujillo, M.E., Tanowitz, H.B., P.E. SCHERER, "Adipocyte, Adipose Tissue, and Infectious Disease" Infection and Immunity, 75(3):1066-1078, 2007
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