Dr. Parmar has spent considerable time in translational research including the dissection of mechanisms of action of Gleevec in chronic myelogenous leukemia, where she found the role of a novel p38 MAP kinase. She also conducted ex-vivo expansion of cord blood T cells in order to improve the immune reconstitution of transplant recipients. She also reported the role of arsenic trioxide as a single agent in elderly patients with acute myelogenous leukemia. She has published several articles in reputable journals regarding her research.
RESEARCH INTERESTS
Chronic Myelogenous Leukemia
Myelodysplastic Syndrome
Multiple Myeloma
RECENT PUBLICATIONS
Zhou L, Nguyen AN, Sohal D, Ma JY, Pahanish P, Gundabolu K, Hayman J, Chubak A, Mo Y, Bhagat T, Das B, Kapoun AM, Navas TA, Parmar S, Kambhampati S, Pellagatti A, Braunschweig I, Zhang Y, Wickrema A, Medicherla S, Boultwood J, Platanias LC, Higgins LS, List AF, Bitzer M, Verma A., "AInhibition of the TGF-{beta} receptor I kinase promotes hematopoiesis in MDS." Blood, 2008 May 12:Epub ahead of print, May 2008
SIGNIFICANT PUBLICATIONS
Parmar S, Smith J, Sassano A, Uddin S, Katsoulidis E, Majchrzak B, Kambhampati S, Eklund EA, Tallman MS, Fish EN, Platanias LC, "Differential regulation of the p70 S6 kinase pathway by interferon {alpha} and imatinib mesylate (STI571) in chronic myelogenous leukemia cells." Blood, epub ahead of print March 2005
Kaur S, Parmar S, Smith J, Katsoulidis E, Li Y, Sassano A, Majchrzak B, Uddin S, Tallman MS, Fish EN, Platanias LC, "Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells." Exp Hematol, 33(5):550-7, May 2005
Parmar S, Rundhaugen LM, Boehlke L, Riley M, Naghan C, Raji A, Frater JL, Tallman MS., "Phase II trial of arsenic trioxide in relapsed and refractory acute myeloid leukemia, secondary leukemia and/or newly diagnosed patients at least 65 years old." Leuk Res, 28(9):909-19, September 2004
Parmar S, Katsoulidis E, Verma A, Li Y, Sassano A, Lal L, Majchrzak B, Ravandi F, Tallman MS, Fish EN, Platanias LC, "Role of the p38 mitogen-activated protein kinase pathway in the generation of the effects of imatinib mesylate (STI571) in BCR-ABL-expressing cells." J Biol Chem, 279(24):5345-52, June 2004
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