Robert B. and Virginia Payne Professorship in Oncology
Academic Title:
Professor
Primary Appointment:
Simmons Comprehensive Cancer Center
Secondary Appointment:
Pharmacology
School:
Southwestern Medical School
Degree Program:
Genetics and Development
Affiliations:
Hamon Center for Therapeutic Oncology Komen Alliance Breast Cancer Research Moncrief Radiation Oncology Center Radiation Oncology Simmons Comprehensive Cancer Center
Stress-Inducible and Noncaspase-Mediated Gene Apoptosis
Targeted Cancer Therapeutics
IGF-1 Pathway Regulation
G2 Checkpoint Areas
RECENT PUBLICATIONS
Ai H, Pink JJ, Shuai X, Boothman DA, Gao J, "Interactions Between Self-Assembled Polyelectrolyte Shells and Tumor Cells" J Biomed Material Res, 73(3):303-12, June 2005
Meyers M, Mqazurek A, Schmutte C, Fishel R, Boothman DA, "DNA Mismatch Repair Detection and Cllular Responses to Damage Caused by 5-fluoro-2’-deoxyuridine Exposure" J Biol Chem, 280(7):5516-26, February 2005
Ough M, Lewis A, Bey EA, Gao J, Ritchie JM, , Boothman DA, et al, "Efficacy of Beta-lapachone in Pancreatic Cancer Treatment: Exploiting the Novel, Therepeutic Target NQO1" Cancer Biol Ther, 4(1):95-102, January 2005
Park HJ, Ahn K-J, Ahn SD, Choi E, Lee SW, Williams, Boothman DA, et al, "Radiation Increases the Sensitivity of Cancer Cells to β-lapachone" Int J Rad Oncol, Biol & Phys, 61(1):212-219, January 2005
Nasongkla N, Shuai X, Ai H, Weinberg BD, Pink J, Boothman DA, Jingming G, "cRGD-functionalized Polymer Micelles for Targeted Doxorubicin or β-lapachone Delivery" Angew Chem Int Ed Engl, 43(46):6323-6327, November 2004
SIGNIFICANT PUBLICATIONS
Reinicke KE, Bey EA, Bentle MS, Pink JJ, Inalls ST, Boothman DB, et al, "Development of β-lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated NAD(P)H:quinone Oxidoreductase 1 Levels" Clin Cancer Res, 11(8):3055-64, April 2005
Sawada M, Sun W, hayes P, Keskov K, Boothman DA, Matuyama S, "Ku70 Suppresses the Apoptotic Translocation of Bax to Mitochondria" Nat Cell Biol, 5(4):320-9, April 2003
Criswell T, Beman M, Araki S, Leskov K, Cataldo E, May LD, Boothman DA, "Delayed Activation of IGF-1RSrc/MAPK Signaling After IR Regulates Clusterin Expression, a Pro-survival Protein" J Biol Chem, 280(14):14212-21, April 2005
Leskov KS, Klokov DY, Li J, Kinsella TJ, Boothman DA, "Synthesis and Functional Analyses of Nuclear Clusterin: a Cell Death Protein" J Biol Chem, 278(13):11590-600, March 2003
Tagliarino C, Pink JJ, Dubyak GR, Nieminen A-L, Boothman DA, "Calcium is a Key Signaling Molecule in β-lapachone-mediated Cell Death" J Biol Chem, 276(22):19150-9, June 2001
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