Despite advances in our understanding of the ultrastructure of eukaryotic cells, the question of how these cells interact to form the tissues of our bodies is still poorly understood. Once formed, we know even less about how these tissues are maintained. My lab is interested in how groups of cells organize themselves into properly sized, polarized tubules and then how these structures are maintained throughout the life of the organism. This is particularly significant as defects in tubule size and maintenance play causal roles in several human diseases including cystic kidney diseases and cancers.
In the lab, we utilize mouse genetics, organ culture (including live cell imaging), cell culture/biology, RNA interference, gene microarrays, in situ hybridization and immunohistochemistry to gain a better understanding of how certain gene products influence cell biology within the context of the whole organ.
RESEARCH INTERESTS
Developmental Biology
Stem/progenitor cells
Cell polarity
Morhpogenesis
Cancer
RECENT PUBLICATIONS
Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ., "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis." Nature Genetics, 41(7):793-799, July 2009
Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F., "Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation." Developmental Cell, 12 (1):113-27, January 2007
Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP, "A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney." Development, 136(1):161-71, January 2009
Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP., "Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature." Science, 322(5905):1247-50, November 2008
Grote D, Boualia SK, Souabni A, Merkel C, Chi X, Costantini F, Carroll T, Bouchard M., "Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction." PLoS Genet., 4(12) December 2008
SIGNIFICANT PUBLICATIONS
Carroll, T. J. and Vize, P, "Synergism between Pax-8 and Lim-1 in embryonic kidney development" Developmental Biology, 214(1):46-59, 1999
Yu, J., Carroll, T.J., and McMahon, A.P., "Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney." Development, 129:5301-12, 2002
Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP., "Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system." Developmental Cell, 9 (2):283-92, August 2005
Marose TD, Merkel CE, McMahon AP, Carroll TJ., "Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state." Dev. Biol., 314(1):112-26, February 2008
Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, McMahon AP., "Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development." Cell Stem Cell, 3(2):169-81, August 2008
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