Current research interests are: 1) The significance of circulating molecular variants of human prolactin with particular reference to glycosylated variant as well as macroprolactin. The research examines biological and immunological effects of these variants, their relative changes in patients with prolactinoma and other hyperprolactinaemic states. 2) The role of circulating levels of IL-6, tumor necrosis factor soluble receptor II, interleukin-1 receptor antagonist in patients with heat-stroke / heat- exhaustion. 3) The significance of interleukin-6 (IL-6) in cerebrospinal fluid from patients with meningitis and in serum from patients suspected of acute coronary syndrome as well as the prognostic value of cytokines in sepsis, trauma, and in patients with poor nutritional status.
RESEARCH INTERESTS
Proteomics
Molecular Heterogeneity of Prolactin
Cytokines in heatstroke, trauma, inflammation, and meningitis
RECENT PUBLICATIONS
I.A. Hashim and M.N. Richi, "Recurrent headache and febrile attacks in a young woman" Laboratory Medicine, 34, (5):354-357, 2003
SIGNIFICANT PUBLICATIONS
Hashim, I.A., Aston, R., Butler, J., McGregor, A.M., Smith, C.R., and Norman, M., "The proportion of glycosylated prolactin in serum is decreased in hyperprolactinemic states" Journal of Clinical Endocrinology and Metabolism, 71,(1):111-115., 1990
Smith, C.R., Butler, J., Hashim, I., and Norman, M.R, "Serum prolactin bioactivity and immunoactivity in hyperprolactinaemic states." Ann Clin Biochem, 27, (1):3-8, 1990
Hashim,I.A., Walsh,A., Hart,C.A., and Shenkin,A, "Cerebrospinal fluid interleukin-6 and its diagnostic value in the investigation of meningitis" Ann Clin Biochem, 32, (3):289-296, 1995
Hashim,I.A., Al-Zeer, A., Shohaib,S., Al-Ahwal,M.,and Shenkin, A, "Cytokine changes in serum from patients with heatstroke during pilgrimage to Makkah" Mediators of Inflammation, 6:135-139, 1997
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