Our research is focused on the cellular and molecular mechanisms underlying axonal regeneration failure and cell death in the damaged CNS. One area of our research is to characterize axonal growth inhibition mediated by the extrinsic factors, such as myelin-derived molecules and glial scar-related proteoglycans, and regulated by the intracellular downstream signaling pathways. Another emphasis of our studies is to understand the intracellular signaling mechanisms underlying the neural cell death in the CNS after injury. The final goal of our studies is to develop the potential repair strategies for the damaged CNS by stimulating axonal regeneration of survived axotomied-neurons and by promoting the survival of injured neural cells.
RESEARCH INTERESTS
Axonal regeneration in the central nervous system
Cell death and neuronal survival
Spinal cord injury
RECENT PUBLICATIONS
Fu Q, Hue J and Li S., "Nonsteroidal Anti-Inflammatory Drugs Promote Axon Regeneration via RhoA Inhibition." J Neurosci, 27:4154-64, April 2007
Cafferty W, Yang S, Duffy P, Li S and Strittmatter SM., "Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans." J Neurosci, 27:2176-85, 2007
Li S, Kim JK, Budel S, Hampton TG and Strittmatter SM, "Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury." Molecular & Cellular Neuroscience, 29:26-39, 2005
Zheng B, .Ho C, .Li S, Keirstead H, Steward O, Tessier-Lavigne M., "Lack of enhanced spinal regeneration in Nogo deficient mice." Neuron, 38:213-224, 2003
Li S and Strittmatter SM, "Delayed systemic Nogo-66 receptor antagonist after spinal cord injury promotes recovery." J Neurosci, 23:4219-4227, 2003
SIGNIFICANT PUBLICATIONS
GrandPre T*, Li S* and Strittmatter SM (*Co-first author), "Nogo-66 receptor antagonist peptide promotes axonal regeneration." Nature, 417:547-551, 2002
Li S, Liu BP, Budel S, Li M, Ji B, Walus L, Jirik A, Rabacchi S, Choi E, Worley D, Sah DWY, Pepinsky B, Lee D, Relton J and Strittmatter SM., "Blockade of Nogo-66, MAG plus OMgp by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury." Journal of Neuroscience, 24:10511-10520, 2004
Kim JK*, Li S*, GrandPre T, Qiu K, Greer CA and Strittmatter SM (*Co-first author), "Axon Regeneration in young adult mice lacking Nogo-A/B." Neuron, 38:187-199, 2003
Li S and Stys PK., "Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter." J Neurosci, 20:1190-98, 2000
Li S, Mealing GAR, Morley P, Stys PK., "Novel injury mechanism in anoxia and trauma of spinal cord white matter: glutamate release via reverse Na+-dependent glutamate transport." J Neurosci, 19:RC 16(1-9), 1999
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