The focus of my research group is synthesis of natural products and large collections of natural product-like small molecules. The particular interests include development of new synthetic strategies and methodologies for complex molecule synthesis, exploration of the modes of action of natural products, identification of new probes for studying cellular pathways, and drug development.
RESEARCH INTERESTS
natural product synthesis
synthetic methodology development
small-molecule library synthesis
chemical biology
RECENT PUBLICATIONS
Lu, J.; Tan, X.; Chen, C., "Palladium-Catalyzed Direct Functionalization of Imidazolinone: Synthesis of Dibromophakellstatin." J. Am. Chem. Soc., 129:7768-7769, 2007
Tan, X.; Chen, C., "Regiocontrol in Manganese(III)-Mediated Oxidative Heterobicyclizations: Access to the Core Skeletons of Oroidin Dimers" Angew. Chem. Int. Ed., 45:4245-4348, 2006
Chen, C.; Li, X.; Neumann, C. S.; Lo, M. M.-C.; Schreiber, S. L., "Convergent Diversity-Oriented Synthesis of Small-Molecule Hybrids." Angew. Chem. Int. Ed.,
Chen, C.; Li, X.; Schreiber, S.L., "Catalytic Asymmetric [3+2] Cycloaddition of Azomethine Ylides. Development of a Versatile Stepwise, Three-Component Reaction for Diversity-Oriented Synthesis." J. Am. Chem. Soc., 125:10174-10175, 2003
Chen, C.; Layton, M. E.; Sheehan, S. M.; Shair, M. D., "Synthesis of (+)-CP-263,114." J. Am. Chem. Soc., 122:7424-7425, 2000
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