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J. Gregory Fitz

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J. Gregory Fitz, M.D.

Details of Research

Name:		J. Gregory Fitz, M.D.
Endowed Title:		Atticus James Gill, M.D. Chair in Medical Science Nadine and Tom Craddick Distinguished Chair in Medical Science
Academic Title:		Professor
Primary Appointment:		Internal Medicine - Digestive and Liver Diseases
Department Website:		Internal Medicine
Email:		J. Gregory Fitz, M.D.

RESEARCH INTERESTS

	Epithelial ion channels
	Purinergic signaling
	Cellular mechanisms of insulin resistance
	Biliary secretion

RECENT PUBLICATIONS

	Feranchak, AP; Kilic, G; Wojtaszek, PA; Qadri, I; Fitz, JG., "Volume-sensitive tyrosine kinases regulate liver cell volume through effects on vesicular trafficking and membrane Na+ permeability" J Biol Chem, in press 2003
	Kilic, G; Fitz, JG, "Heterotrimeric G-proteins activate Cl- channels through stimulation of a cyclooxygenase-dependent pathway in a model liver cell line" J Biol Chem, 277:11721-11727, 2002
	Doctor, RB; Dahl, R; Fouassier, L; Kilic, G; Fitz, JG, "Cholangiocytes exhibit dynamic, actin-dependent apical membrane turnover" Am J Physiol, C1042-C1052, 2002
	Braunstein, GM; Roman, RM; Clancy, JP; Kudlow, BA; Taylor, AL; Shylonsky, V; Jovov, B; Peter, K; Jilling, T; Guggino, WB; Ismailov, II; Collawn, JF; Benos, DJ; Schweibert, LM, Fitz, JG; Schweibert, EM, "CFTR facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume." J Biol Chem, 276:6621-6630, 2001
	Roman, RM; Smith, RL; Feranchak, AP; Clayton, GH; Doctor, RB; Fitz, JG, "CIC-2 chloride channels contribute to HTC cell volume homeostasis" Am J Physiol, 280:G344-G353, 2001

SIGNIFICANT PUBLICATIONS

	Feranchak, AP; Berl, T; Capasso, J; Wojtaszek, PA; Han, J; Fitz, JG, "P38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability" J Clin Invest, 108:1495-1504, 2001
	Roman, RM; Lomri, N; Braunstein, GM; Feranchak, AP; Simeoni, L; Davison, A; Mechetner, EB; Schweibert, EM; Fitz, JG, "Evidence for multidrug resistance 1 P-glycoprotein-dependent regulation of cellular ATP permeability" J Membrane Biology, 183:165-173, 2001
	Kilic, G; Doctor, RB; Fitz, JG, "Insulin stimulates membrane conductance in a liver cell line: evidence for vesicular insertion of ion channels through a phosphoinositol 3-kinase-dependent mechanism" J Biol Chem, 276:26762-26768, 2001
	Roman, R; Wang, Y; Lidofsky, SD; Feranchak, AP; Lomri, N; Scharschmidt, BF; Fitz, JG, "Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume" J Biol Chem, 272:21970-21976, 1997
	Wang, Y; Roman, R; Lidofsky, SD; Fitz, JG, "Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation" Proc Nat Acad Sci USA, 93:12020-12025, 1996

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