X-ray crystallography, biochemistry of membrane proteins & electrophysiology
RCK domain mediated gating of Ion Channels
RECENT PUBLICATIONS
Jiang Y, Lee A, Chen J, Ruta V, Cadene M, Chait BT, MacKinnon R, "X-ray structure of a voltage-dependent K+ channel." Nature, 423(6935):33-41, May 2003
Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R, "The principle of gating charge movement in a voltage-dependent K+ channel." Nature, 423(6935):42-8, May 2003
Dong J, Shi N, Berke I, Chen L, Jiang Y, "Structures of the MthK RCK domain and the effect of Ca2+ on gating ring stability." J Biol Chem, 280(50):41716-24, December 2005
Shi N, Ye S, Alam A, Chen L, Jiang Y, "Atomic structure of a Na+- and K+-conducting channel." Nature, 440(7083):570-4, March 2006
Ye S, Li Y, Chen L, Jiang Y, "Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels." Cell, 126(6):1161-73, September 2006
SIGNIFICANT PUBLICATIONS
Yong Wang, Youxing Jiang, Martina Meyering-Voss, Mathias Sprinzl & Paul B. Sigler, "Crystal structure of the EF-Tu.EF-Ts complex from Tthermus thermophilus" Nature Structural Biology, 4(8):650-656, August 1997
Youxing Jiang, Alexander Pico, Martine Cadene, Brian T. Chait, and Roderick MacKinnon, "Structure of the RCK domain from the E. coli K+ channel and demonstration of Its Presence in the Human BK Channel" Neuron, 29:593-601, March 2001
Youxing Jiang and Roderick MacKinnon, "The barium site in a potassium channel by X-ray crystallography" J. Gen. Physiol., 115:269-272, March 2000
Youxing Jiang, Steffen Nock, Martina Nesper, Mathias Sprinzl & Paul B. Sigler, "Structure and importance of the dimerization domain in elongation factor Ts from thermus thermophilus" Biochemistry, 35 (32):10269 -10278, 1996
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