1. Dopamine and NH3 2. Klotho and mineral metabolism
RESEARCH INTERESTS
Renaly physiology
Mineral metabolism
RECENT PUBLICATIONS
Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW, Kuro-O M., "Regulation of fibroblast growth factor-23 signaling by klotho." J Biol Chem, 281/10:6120-6123, March 2006
Mill P, Mo R, Hu MC, Dagnino L, Rosenblum ND, Hui CC, "Shh Controls Epithelial Proliferation via Independent Pathways that Converge on N-Myc." Dev Cell, 9:293-303, 2005
Hu MC, Rosenblum ND., "Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription." Development., 132(1)::215-25, January 2005
Hu MC, Wasserman D, Hartwig S, Rosenblum ND., "p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1." J Biol Chem. 2004 Mar, 279(13):12051-9, March 2005
Klisic J, Hu MC, Nief V, Reyes L, Fuster D, Moe OW, Ambuhl PM., "Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependence." Am J Physiol Renal Physiol. 2002 Sep;, 283(3)::F532-9., August 2002
SIGNIFICANT PUBLICATIONS
Hu MC, Piscione TD, Rosenblum ND., "Elevated SMAD1/beta-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice." Development., 130(12)::2753-66., May 2003
Hu MC, Rosenblum ND., "Genetic regulation of branching morphogenesis: lessons learned from loss-of-function phenotypes." Pediatr Res., 54(4)::433-8., October 2003
Hu MC, Fan L, Crowder LA, Karim-Jimenez Z, Murer H, Moe OW., "Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylation." J Biol Chem., 276(29):26906-15., July 2001
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