A significant goal in medicine is the development of methods for cell-specific targeting of therapeutic molecules. While the concept of the "magic bullet drug" was introduced over 100 years ago, medicine has yet to realize this goal. Our laboratory is developing platform technologies to identify targeting reagents that can home to specific cell types in vivo. The current scientific goals of the research group are to 1) develop comprehensive technologies that enable cell-specific delivery of biologically active molecules in vivo 2) map unique cellular features of the cell-surface that can be exploited as recognition moieties for cell-specific delivery and 3) understand how the cell surface reorganizes in response to a disease state. Our approach is multi-faceted encompassing biochemistry, organic chemistry, and molecular and cellular biology.
RESEARCH INTERESTS
cell-specific targeting
receptor-ligand interactions
lung cancer
drug delivery
cancer biomarker identification
RECENT PUBLICATIONS
Samli, Kausar N.; McGuire, Michael J.; Newgard, Christopher B.; Johnston, Stephen Albert; Brown, Kathlynn C, "Peptide-Mediated Targeting of the Islets of Langerhans" Diabetes, 54:2103-2108, 2005
McGuire, Michael J.; Sykes, Kathryn F.; Samli, Kausar N.; Timares, Laura; Barry, Michael A.; Stemke-Hale, Katherine; Tagliaferri, Frank; Logan, Mark; Jansa, Kimberly; Takashima, Akira; Brown, Kathlynn C.; Johnston, Stephen Albert, "A Library-Selected, Langerhans Cell-Targeting Peptide Enhances an Immune Response" DNA Cell Biol., 23:742-752, 2004
Elayadi, Anissa N.; Samli, Kausar N.; Prudkin, Ludmila; Liu, Ying-horng; Bian, Aihua; Xie, Xian-Jin; Wistuba, Ignacio I.; Roth, Jack A.; McGuire, Michael J.; Brown, Kathlynn C., "A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for non-small cell lung cancer" Cancer Research, 67:5889-5895, Summer 2007
McGuire, Michael J.; Samli, Kausar N.; Chang Ya-Ching; Brown Kathlynn C., "Novel Ligands for Cancer Diagnosis: Selection of Peptide Ligands for Identification and Isolation of B-Cell Lymphomas" Experimental Hematology, 34:443-452, Winter 2006
Oyama, Tsukasa; Rombel, Irene T.; Samli, Kausar N.; Zhou Xin; Brown, Kathlynn C., "Isolation of multiple cell-binding ligands from different phage displayed-peptide libraries" Biosensors & Bioelectronics, 21:1867-1875, Winter 2006
SIGNIFICANT PUBLICATIONS
Brown, Kathlynn C.; Yu, Zhonghua; Burlingame, Alma L.; Craik, Charles S., "Determining Protein-Protein Interactions by Oxidative Cross-linking of a GGH-Fusion Protein" Biochemistry, 37:4397-4406, 1998
Brown, Kathlynn C.; Yang, Sang-Hwa; and Kodadek, Thomas, "Highly Specific Oxidative Crosslinking of Proteins Mediated by a Nickel-Peptide Complex" Biochemistry, 34:4733-4739, 1995
Maxwell, Jana L.; Brown, Kathlynn C.; Bartley, David W. and Kodadek, Thomas, "Mechanism of the Rhodium Porphyrin-Catalyzed Cyclopropanation of Alkenes: Spectroscopic and Kinetic Characterization of Organometallic Intermediates" Science, 256:1544-1547, 1992
Oyama, Tsukasa, Sykes, Kathryn F., Samli, Kausar, N., Minna, John D., Johnston, Stephen Albert, Brown, Kathlynn C, "Isolation of Lung Tumor Specific Peptides from a Random Library: Generation of Diagnostic and Cell-targeting Reagents" Cancer Lett., 202:219-230, 2003
Zhou, Xin; Chang, Ya-Ching; Oyama, Tsukasa; McGuire, Michael J.; Brown, Kathlynn C., "Cell-Specific Delivery of a Chemotherapeutic to Lung Cancer Cells" Journal of the American Chemical Society, 126:15656-15657, 2004
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