Our laboratory utilizes mouse genetics to delineate the genetic basis for autoimmune disease pathogenesis. Our primary focus has been on systemic lupus erythematosus (SLE), a debilitating autoimmune disease initiated via a profound loss of immunologic tolerance to nuclear antigens. We have used genetic manipulation of the lupus-prone NZM2410 murine model of SLE to dissect SLE pathogenesis into a series of discrete stages. We are currently in the process of identifying the individual susceptibility genes and defining the genetic pathways responsible for the initiation and progression of systemic autoimmunity in lupus-prone mouse models of SLE. Additional projects within the laboratory include genetic dissections of autoimmune diabetes and the analysis of a variety of polymorphisms in normal immune functions. The use of microarray technology in combination with genetic fine mapping to identify polymorphic genes with potent immunologic effects is a major new thrust within the laboratory.
RESEARCH INTERESTS
Molecular genetics of susceptibility to autoimmune diseases
Genetic variability in the immune system
RECENT PUBLICATIONS
Subramanian, S., Tus, K., Li, Q.-Z., Wang, A., Tain, X.-H., Zhou, J., Liang, C., Barov, G., McDaniel, L.D., Zhou, X.J., Schultz, R.A., and Wakeland, E.K., "From the cover: A Tlr7 translocation accelerates systemic autoimmunity in murine lupus" Proc. Natl. Acad. Sci., 103:9970-9975, 2006
Kumar, K.R., Li, L., Yan, M, Bhaskarabhatla, M., Mobley, A.B., Nguyen, C., Mooney, J.M., Schatzle, J.D., Wakeland, E.K, and Mohan, C., "Regulation of B cell tolerance by the lupus susceptibility gene Ly108" Science, 312:1665-1669, 2006
Point and right click (click and hold for Mac users) your mouse onand select "Save this link (or target) as..." option to save the file to your local computer.
and select "Save this link (or target) as..." option to save the file to your local computer.