The focus of the Liang laboratory is to study the molecular mechanism by which dysregulation of lipid metabolism contributes to the development of diseases such as obesity, diabetes, and birth defects. Currently, we are using genetically modified rodent models to elucidate the physiological roles of SREBP, Scap, and Insig. To achieve this goal, we have generated various mutant mouse lines that either lack or overexpress these key regulators of lipid metabolism in specific tissues such as brain, liver, and muscle.
RESEARCH INTERESTS
Cholesterol homeostasis
Metabolic diseases such as obesity and diabetes
Transcriptional regulation
RECENT PUBLICATIONS
Guan,H.P., Goldstein, J.L., Brown, M.S., and Liang, G., "Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice." J. Biol. Chem., 284:24644-52, September 2009
Yang, J., Brown, M.S., Liang, G., Grishin, N.V., Goldstein, J.L., "Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone." Cell, 132:387-396, 2008
Engelking, L.J., Evers, B.M., Richardson, J.A., Goldstein, J.L., Brown, M.S. and Liang, G., "Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin" J. Clin. Invest., 116:2356-2365, September 2006
Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS., "Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins" J Clin Invest, 115 (9):2489-2498, September 2005
Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS., "Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver." Cell Metab, 1(1):41-51, January 2005
SIGNIFICANT PUBLICATIONS
Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS., "Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins." J Clin Invest., 115(9):2489-98, September 2005
Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS., "Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver." Cell Metab., 1(1):41-51, January 2005
Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS., "Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c." J Biol Chem., 277(11):9520-8, March 2002
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ., "Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta." Genes Dev., 14(22):2819-30., November 2000
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