Multivalent feedback regulation of HMG CoA reductase
Endoplasmic Reticulum Associated Degradation
Cell Regulation
RECENT PUBLICATIONS
Debose-Boyd, R.A., "A helping hand for cytochrome p450 enzymes." Cell Metab., 5:81-83, 2007
Nguyen, A.D., McDonald, J.G., Bruick, R.K., DeBose-Boyd, R.A., "Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs." J. Biol. Chem., 282:27436-27446, 2007
DeBose-Boyd, R.A., "Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase." Cell Res., 18:609-21, 2008
Lee, P.C., Debose-Boyd, R.A., "Intramembrane glycine mediates multimerization of insig-2, a requirement for sterol regulation in chinese hamster ovary cells." J. Lipid Res., Epub ahead of print, July 2009
Nguyen, A.D., Lee, S.H., DeBose-Boyd, R.A., "Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells." J. Biol. Chem., 284:26778-88, September 2009
SIGNIFICANT PUBLICATIONS
DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J., "Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi" Cell, 99:703-712, 1999
Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A, "Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain" Molecular Cell, 11:25-33, 2003
Bao-Liang Song and Russell A. DeBose-Boyd, "Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase" Journal of Biological Chemistry, 279:28798-28806, July 2004
Bao-Liang Song, Norman B. Javitt, and Russell A. DeBose-Boyd, "Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol" Cell Metabolism, 1:179-189, March 2005
Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd, "Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase" Molecular Cell, 19:829-840, September 2005
Point and right click (click and hold for Mac users) your mouse onand select "Save this link (or target) as..." option to save the file to your local computer.
