Multivalent feedback regulation of HMG CoA reductase
Endoplasmic Reticulum Associated Degradation
Cell Regulation
RECENT PUBLICATIONS
Debose-Boyd, R.A., "A helping hand for cytochrome p450 enzymes." Cell Metab., 5:81-83, 2007
Lee, P.C., Liu, P., Li, W.P., Debose-Boyd, R.A., "Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells." J. Lipid Res., 48:1944-1954, 2007
Nguyen, A.D., McDonald, J.G., Bruick, R.K., DeBose-Boyd, R.A., "Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs." J. Biol. Chem., 282:27436-27446, 2007
Cao, J., Wang, J., Qi, W., Miao, H.H., Wang, J., Ge, L., DeBose-Boyd, R.A., Tang, J.J., Li, B.L., Song, B.L., "Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase." Cell Metab., 6:115-128, 2007
DeBose-Boyd, R.A., "Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase." Cell Res., 18:609-21, 2008
SIGNIFICANT PUBLICATIONS
DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J., "Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi" Cell, 99:703-712, 1999
Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A, "Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain" Molecular Cell, 11:25-33, 2003
Bao-Liang Song and Russell A. DeBose-Boyd, "Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase" Journal of Biological Chemistry, 279:28798-28806, July 2004
Bao-Liang Song, Norman B. Javitt, and Russell A. DeBose-Boyd, "Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol" Cell Metabolism, 1:179-189, March 2005
Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd, "Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase" Molecular Cell, 19:829-840, September 2005
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